Furofurans
Cantharidin 98.0+%, TCI America™
CAS: 56-25-7 Molecular Formula: C10H12O4 Molecular Weight (g/mol): 196.202 MDL Number: MFCD00134968 InChI Key: DHZBEENLJMYSHQ-XCVPVQRUSA-N Synonym: cantharidin,cantharone,cantharidine,kantaridin,kantharidin,cantharides camphor,kantharidin german,caswell no. 157,1,2-dimethyl-3,6-epoxyperhydrophthalic anhydride,unii-igl471wq8p PubChem CID: 5944 ChEBI: CHEBI:64213 SMILES: CC12C3CCC(C1(C(=O)OC2=O)C)O3
![exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride, 98%](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-29745-04-8.jpg-250.jpg)
exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride, 98%
CAS: 29745-04-8 Molecular Formula: C8H8O4 Molecular Weight (g/mol): 168.148 MDL Number: MFCD00213361 InChI Key: JAABVEXCGCXWRR-GUCUJZIJSA-N Synonym: exo-3,6-Epoxyhexahydrophthalic anhydride; Norcantharadin PubChem CID: 12251906 SMILES: C1CC2C3C(C1O2)C(=O)OC3=O
Cantharidin, 98%, Thermo Scientific Chemicals
CAS: 56-25-7 Molecular Formula: C10H12O4 Molecular Weight (g/mol): 196.202 MDL Number: MFCD00134968 InChI Key: DHZBEENLJMYSHQ-XCVPVQRUSA-N Synonym: cantharidin,cantharone,cantharidine,kantaridin,kantharidin,cantharides camphor,kantharidin german,caswell no. 157,1,2-dimethyl-3,6-epoxyperhydrophthalic anhydride,unii-igl471wq8p PubChem CID: 5944 ChEBI: CHEBI:64213 SMILES: CC12C3CCC(C1(C(=O)OC2=O)C)O3
![4,9,11-Trioxatetracyclo[5.3.1.0(2,6).0(8,10)]undecan-3-one 98.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-632339-23-2.jpg-250.jpg)
4,9,11-Trioxatetracyclo[5.3.1.0(2,6).0(8,10)]undecan-3-one 98.0+%, TCI America™
CAS: 632339-23-2 Molecular Formula: C8H8O4 Molecular Weight (g/mol): 168.15 MDL Number: MFCD10566937 InChI Key: UAFDSOCDQRHNCL-UHFFFAOYNA-N Synonym: 2,6-Epoxy-2,2a,5,5a,6,6a-hexahydrooxireno[f]isobenzofuran-3(1aH)-one PubChem CID: 20632532 IUPAC Name: 4,9,11-trioxatetracyclo[5.3.1.0²,⁶.0⁸,¹⁰]undecan-3-one SMILES: O=C1OCC2C3OC(C4OC34)C12
Norcantharidin 98.0+%, TCI America™
CAS: 29745-04-8 Molecular Formula: C8H8O4 Molecular Weight (g/mol): 168.148 MDL Number: MFCD00213361 InChI Key: JAABVEXCGCXWRR-GUCUJZIJSA-N Synonym: exo-3,6-Epoxyhexahydrophthalic Anhydride, exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Anhydride PubChem CID: 12251906 SMILES: C1CC2C3C(C1O2)C(=O)OC3=O
![4,10-Dioxatricyclo[5.2.1.0(2,6)]decan-8-en-3-one 97.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-72150-22-2.jpg-250.jpg)
4,10-Dioxatricyclo[5.2.1.0(2,6)]decan-8-en-3-one 97.0+%, TCI America™
CAS: 72150-22-2 Molecular Formula: C8H8O3 Molecular Weight (g/mol): 152.149 InChI Key: KIAQKKYOUVIGII-UHFFFAOYSA-N Synonym: 4,7-Epoxy-3a,4,7,7a-tetrahydroisobenzofuran-1(3H)-one PubChem CID: 331417 SMILES: C1C2C3C=CC(C2C(=O)O1)O3
Medchemexpress LLC Vociprotafib (RMC-4630) | 2172652-48-9 | 99.70% | C20H27ClN6O2S | 100 MG
Vociprotafib (RMC-4630) is an orally active, selective, and potent phosphatase SHP2 inhibitor. It functions by blocking the activation of the RAS-RAF-MEK-ERK signaling pathway, demonstrating antitumor activity. This compound accelerates tumor regressions in Osimertinib-sensitive EGFR-mutant tumors and delays tumor regrowth after treatment.
- Orally active, selective, and potent phosphatase SHP2 inhibitor
- Blocks activation of the RAS-RAF-MEK-ERK signaling pathway
- Demonstrates antitumor activity
- Accelerates tumor regressions in EGFR-mutant tumors
- Delays tumor regrowth after treatment cessation
- Effective against tumors resistant to Osimertinib via c-MET amplification
- Investigated in a phase 1 clinical trial for KRAS-mutant non-small cell lung cancer
- Considered a foundational approach for targeted therapy combinations in RAS pathway driven cancers
Medchemexpress LLC Astragaloside II | 84676-89-1 | 827.01 | 100 MG
Astragaloside II is an orally active Cycloartane-type triterpene glycoside extracted from *Astragalus membranaceus*. It is used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis. It functions by inhibiting autophagy, decreasing pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, and p-IκB, and increasing superoxide dismutase (SOD). It also regulates immunity and reduces inflammatory responses.
- Promotes cell viability of rat primary osteoblasts.
- Enhances proliferation of primary splenocytes.
- Sensitizes cells to 5-fluorouracil-induced cell death.
- Inhibits levels of HIF-α, p-p65, and p-IκB, demonstrating an anti-inflammatory effect.
- Alleviates symptoms of DSS-induced ulcerative colitis in mice.
- Reduces DAI score and prevents body weight loss in vivo.
- Increases colon length and superoxide dismutase in colon tissues.
Medchemexpress LLC SB 204990 | 154566-12-8 | 99.8% | 389.27 | 100 MG
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. It is for research use only. SB 204990 treatment leads to a decrease in cytosolic Ac-CoA levels, which is expected to decrease acetylated and active β-catenin levels. When administered orally to rats, it is absorbed into the systemic circulation, causing a dose-related decrease in plasma cholesterol and triglyceride levels. In dogs, it also decreases plasma cholesterol and triglyceride levels, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
- Potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
- Decreases cytosolic Ac-CoA levels.
- Reduces acetylated and active β-catenin levels.
- Decreases plasma cholesterol and triglyceride levels in rats and dogs.
- Preferentially decreases low-density lipoprotein compared with high-density lipoprotein cholesterol levels in dogs.
Medchemexpress LLC (Rac)-Norcantharidin | 5442-12-6 | 168.15 | 1 ML
(Rac)-Norcantharidin ((Rac)-NCTD) is the racemic form of Norcantharidin. Norcantharidin is a demethylated derivative of Cantharidin and has antitumor activity. This product is supplied as a 10 mM solution in 1 mL of DMSO, making it suitable for various research applications.
- Demethylated derivative of cantharidin.
- Exhibits antitumor activity.
- Supplied as a 10 mM solution.
- Provided in 1 mL volume.
- Formulated in DMSO.
Medchemexpress LLC (32-carbonyl)-RMC-5552 | 2382768-55-8 | 95.0% | 1776.11 | C93H134N10O24 | 5 MG
(32-Carbonyl)-RMC-5552 is a small-molecule research inhibitor of the mechanistic target of rapamycin (mTOR) that potently inhibits phosphorylation of mTORC1 and mTORC2 substrates. It is intended for biochemical and cellular studies of PI3K/Akt/mTOR signaling and is supplied with analytical characterization for research use.
- Potent dual inhibition of mTORC1 and mTORC2.
- Useful in biochemical and cellular pharmacology studies.
- Characterized molecular properties and CAS identifier for traceability.
- Available as small-scale dry packs and as a DMSO solution for convenient dosing.
- Includes analytical data to support quality control.
Medchemexpress LLC HY-B0739 100mg Medchemexpress, Citicoline CAS:987-78-0 Purity:>98%
Medchemexpress, HY-B0739 100mg Citicoline CAS:987-78-0 Citicoline (Cytidine diphosphate-choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Timosaponin C | 185432-00-2 | 5 MG
Timosaponin C is isolated from Rhizoma Anemarrhenae. It shows weaker NO inhibition in N9 microglial cells.
- Isolated from Rhizoma Anemarrhenae.
- Shows weaker NO inhibition in N9 microglial cells.
- Appearance: White to off-white solid.
Medchemexpress LLC Dimethylamino Parthenolide | 791595-09-0 | 98.0% | 293.40 | 100 MG
DMAPT (Dimethylamino Parthenolide) is an analogue of Parthenolide (PTL) and an orally active NF-κB inhibitor. It has an LD50 of 1.7 μM for cell population in AML cells and demonstrates potential anti-cancer and anti-metastatic effects. This product is for research use only.
- Decreases constitutive NF-κB binding activity
- Inhibits cell proliferation and viability in PC-3 and DU145 cells
- Increases sensitivity of PC-3 tumor xenografts to X-rays
- Slows normal tumor development in TRAMP mice
- Reduces metastatic area in lung tissues in TRAMP mice
Medchemexpress LLC HY-111453 5mg Medchemexpress, AZD7594 CAS:1196509-60-0 Purity:>98%
Medchemexpress, HY-111453 5mg AZD7594 CAS:1196509-60-0 AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.