Imidazopyrimidines
Medchemexpress LLC BioE-1115 | 1268863-35-9 | 98.2% | 50 MG
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of approximately 4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of about 10 μM.
- Highly selective and potent PAS kinase (PASK) inhibitor
- Potent casein kinase 2α inhibitor
- Dose-dependent loss of PASK phosphorylation in HEK293 cells
- Reduces SREBP activity in HepG2 cells
- Suppresses Gpat1, Fasn, and other SREBP-1c target genes in rats
- Decreases hepatic expression of lipogenic SREBP-1c target genes
- Reduces serum triglycerides and partially reverses insulin resistance
- Decreases HOMA-IR and significantly decreases serum glucose
Medchemexpress LLC 3-isobutyl-1-methylxanthine | 28822-58-4 | MFCD00005584 | 100.0% | 222.24 | C10H14N4O2 | 25MG
IBMX (3-Isobutyl-1-methylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor used as a research reagent to elevate intracellular cyclic nucleotides by inhibiting multiple PDE isoforms. It is supplied as a stable solid with documented physicochemical, purity, and solubility data for preparation of in vitro and in vivo formulations.
- Broad-spectrum PDE inhibitor with reported IC50s of 6.5 μM (PDE3), 26.3 μM (PDE4), and 31.7 μM (PDE5).
- Molecular formula C10H14N4O2; molecular weight 222.24 g/mol.
- High purity suitable for research (reported purities ~99.97-99.99%).
- Soluble in DMSO (125 mg/mL) and compatible with published in vivo cosolvent formulations.
- Available in multiple solid pack sizes, including 25 MG, for assay preparation.
- Recommended storage: powder -20°C (short term refrigerated at 4°C), in solvent -80°C for long term.
TARGETMOL CHEMICALS INC XANTHINE OXIDOREDUCTASE- 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor that inhibits XOR with an IC50 value of 29.3 nM.Xanthine oxidoreductase-IN-4 can be used to study hyperuricemia. purity: 98%
Medchemexpress LLC 8-chloro caffeine | 4921-49-7 | MFCD00047246 | 99.4% | 228.64 g·mol⁻¹ | C8H9ClN4O2 | 100 MG
8-Chloro caffeine is a chlorinated derivative of the methylxanthine alkaloid caffeine that binds adenosine receptors (reported Ki = 30 μM). It is supplied as a white to off-white solid for laboratory research and includes documented physicochemical and storage recommendations.
- Binds adenosine receptors (reported Ki = 30 μM).
- Derivative of caffeine useful for receptor-binding and pharmacology studies.
- Molecular formula C8H9ClN4O2; molecular weight 228.64 g·mol⁻¹.
- High purity (approximately 99.4%).
- Solid, white to off-white appearance for easy handling.
- Store powder at -20°C for long-term stability; store in solvent at -80°C for up to 6 months.
Apexbio Technology LLC XAC 96865-92-8 5mg
XAC is a small-molecule antagonist targeting adenosine receptors It is designed to competitively inhibit the binding of adenosine to its receptors thereby modulating receptor-mediated signaling pathways XAC exerts its biological activity primarily through interference with adenosine-induced signaling Experimental studies indicate that XAC inhibits adenosine-induced cellular processes such as neurotransmission modulation and cardiovascular responses Based on these pharmacological properties XAC holds research potential in neuroscience and cardiovascular physiology to investigate adenosine-mediated signaling pathways in specific cellular events and physiological conditions
Medchemexpress LLC Theophylline (Standard) | 58-55-9 | 99.99% | 100 MG
Theophylline (Standard) is the analytical standard of Theophylline, intended for research and analytical applications. It functions as a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. It can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
- Inhibits PDE3 activity to relax airway smooth muscle
- Possesses anti-inflammatory activity by increasing IL-10 and inhibiting NF-κB into the nucleus
- Induces apoptosis
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC HY-W017163 50mg Medchemexpress, 7-Methylxanthine CAS:552-62-5 Purity:>98%
Medchemexpress, HY-W017163 50mg 7-Methylxanthine CAS:552-62-5 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 7-methylxanthine | 552-62-5 | MFCD00037979 | >=98.0% | 166.14 g/mol | C6H6N4O2 | 1 ML
7-methylxanthine is a methylated xanthine derivative used in biochemical and pharmacological research as an adenosine receptor antagonist and endogenous metabolite. Supplied for research and analytical applications, it has formula C6H6N4O2 and a molecular weight of 166.14 g/mol. Purity is commonly reported as >=98.0% (HPLC); consult the certificate of analysis for batch-specific purity.
- Adenosine receptor antagonist and endogenous metabolite for receptor and metabolism studies.
- Chemical identity: CAS 552-62-5, formula C6H6N4O2, molecular weight 166.14 g/mol.
- Available as solid formats and can be prepared or provided as a 10 mM solution in DMSO.
- Typical purity reported as >=98.0% (HPLC); verify with certificate of analysis.
- Intended for research and analytical applications; not for human or clinical use.
Medchemexpress LLC Xanthosine 5'-monophosphate sodium salt | 25899-70-1 | 99.6% | 408.17 | 100 MG
Xanthosine 5'-monophosphate sodium salt is an intermediate in purine metabolism. It is a solid, white to light yellow in color, and soluble in H2O (100 mg/mL, 245.00 mM; requires ultrasonic).
- Can be used for genetic code, nucleic acid structure, and DNA, RNA and protein synthesis research.
- Potential use in foods as a flavoring agent.
- Chemical intermediate for the production of purine antimetabolites.
- Valuable in the production of synthetic polynucleotides for studies on the genetic code, protein synthesis, and nucleic acid structure.
eMolecules 503619-25-8 | Amino-cyclopentyl-acetic acid hydrochloride | J & W PharmLab LLC | MFCD16817562 | 179.640 | C7H14ClNO2 | 96.000 | Cl.NC(C1CCCC1)C(O)=O | 5g | 309209553
Amino-cyclopentyl-acetic acid hydrochloride | J & W PharmLab LLC | 503619-25-8 | MFCD16817562 | 179.640 | C7H14ClNO2 | 96.000 | Cl.NC(C1CCCC1)C(O)=O | 5g | 309209553
Medchemexpress LLC Xanthine Oxidase Antibody (YA1957) | 100 UL
Xanthine Oxidase Antibody (YA1957) is a rabbit-derived, non-conjugated IgG monoclonal antibody, specifically designed to target Xanthine Oxidase. This antibody is characterized by a predicted and observed molecular weight of 146 kDa, making it suitable for various research applications requiring specific detection of Xanthine Oxidase.
- Rabbit-derived, non-conjugated IgG monoclonal antibody
- Targets Xanthine Oxidase
- Predicted and observed molecular weight of 146 kDa
- Suitable for Western Blot (WB) and Immunohistochemistry-Paraffin (IHC-P) experiments
- Validated for use in human, mouse, and rat samples
Medchemexpress LLC BioE-1115 | 1268863-35-9 | 98.2% | 10 MG
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM.
- Highly selective PASK inhibitor (IC50 ~4 nM).
- Potent casein kinase 2α inhibitor (IC50 ~10 μM).
- Induces dose-dependent loss of PASK phosphorylation in HEK293 cells.
- Reduces SREBP activity in HepG2 cells without affecting cell morphology or growth.
- Suppresses SREBP-1c target gene expression and SREBP-1 maturation in liver in vivo.
- Decreases insulin resistance, hepatic/serum triglycerides, and serum glucose dose-dependently.
- Does not cause significant changes in liver or body weight.
Chem-Impex International, Inc. Caffeine, anhydrous | 58-08-2 | MFCD00005758 | 1KG
Caffeine, anhydrous, 58-08-2, MFCD00005758, 1KG
Frontier Specialty Chemicals 1G 6-BROMOIMIDAZO 1,2-A PYRIMI
6-Bromoimidazo[1,2-a]pyrimidine; CAS: 865156-68-9; 1g