Lactams
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 25 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins and is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Related to cancer, cancer targeted therapy, cancer metabolism and metastasis
- Related to autophagy and apoptosis
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
![Medchemexpress LLC 5-[(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-isoindole-1,3-dione | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000284650.png-250.jpg)
Medchemexpress LLC 5-[(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-isoindole-1,3-dione | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 50 MG
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate that contains a terminal alkyne for bioorthogonal conjugation. It is provided as a small-quantity research reagent intended for PROTAC development and target protein conjugation. Reported properties include a molecular formula of C16H13N3O4, a molecular weight of 311.29 g/mol, and a reported purity of 98.0%.
- Contains an E3 ligase ligand with a terminal alkyne for conjugation.
- Designed for PROTAC development and target protein degradation studies.
- Reported purity 98.0% suitable for research applications.
- Provided as a small-quantity reagent (50 mg) for synthetic chemistry workflows.
- Molecular formula C16H13N3O4; molecular weight 311.29 g/mol.
- Store and handle according to supplier safety data sheet recommendations.
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 25 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide designed as a chemical probe and building block for targeted protein degradation and molecular-glue research. Supplied as a research reagent for laboratory use only (not for human or clinical applications).
- Tetrazine-tagged thalidomide derivative for click chemistry (iEDDA).
- Suitable as a building block in PROTAC and molecular-glue studies.
- High purity, typically 98.6%.
- Available in small research pack sizes, including 25 mg.
- Molecular formula C29H29N7O6; molecular weight 571.58 g/mol.
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.
Medchemexpress LLC DDL-357 | 3077900-08-1 | 98.3% | 440.95 | 100 MG
DDL-357 is a potent secreted clusterin enhancer that reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only and not sold to patients.
- Potent secreted clusterin enhancer
- Reduces phospho-tau in brain
- Improves memory in the murine 3xTg-AD model
- For research use only
eMolecules Broadpharm / Thalidomide-5-(PEG4-amine) / 100mg / 713699642 / BP-28032 / / / [null] / 520.539 / C24H32N4O9
Broadpharm / Thalidomide-5-(PEG4-amine) / 100mg / 713699642 / BP-28032 / / / [null] / 520.539 / C24H32N4O9
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 | C15H14ClN3O4 | 5 MG
Thalidomide-pyrrolidine hydrochloride is a cereblon-binding E3 ligase ligand supplied as the hydrochloride salt for use as a building block in PROTAC synthesis and targeted protein degradation research. It is intended for research use and is accompanied by quality documentation.
- Cereblon-binding E3 ligase ligand for PROTAC synthesis.
- Hydrochloride salt form for handling and stability.
- High purity: 98.0%.
- Documented quality: data sheet, certificate of analysis, and safety data sheet available.
- Storage recommendations: store dry at room temperature; in solvent, -80°C (2 years) or -20°C (1 year).
Cayman Chemical ThalIdomIde 5mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 5 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ubiquitin ligase ligand supplied as the hydrochloride salt for research use. It is a light-yellow solid with high reported purity and is intended for use in PROTAC synthesis and related chemical biology applications.
- Used as a ligand for cereblon (CRBN) in PROTAC synthesis.
- High purity (98.9%) suitable for research applications.
- Provided as a hydrochloride salt for improved handling.
- Light yellow solid form for easy weighing and storage.
- Storage: room temperature; in solvent, -80°C (2 years) or -20°C (1 year).
- Available in multiple package sizes including gram-scale quantities.
Medchemexpress LLC 6h-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6s)- | 3077900-08-1 | 98.31% | 440.95 | 1 ML
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Potent secreted clusterin enhancer.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | MFCD34180776 | 99.4% | 355.12 g·mol⁻1 | C13H8BrFN2O4 | 25 MG
Thalidomide-4-F,5-Br is a halogenated thalidomide analogue that functions as an E3 ligase recruiting ligand for targeted protein degradation research. Supplied as a powder in small pre-weighed quantities, it is intended for research use in PROTAC development and studies of ubiquitin-mediated proteolysis.
- Halogenated thalidomide derivative (fluoro and bromo substitutions).
- Acts as a cereblon (CRBN) E3 ligase recruiting ligand for PROTAC applications.
- High purity suitable for research (approximately 99.4%).
- Provided as a powder for easy handling and formulation.
- Available in small pre-weighed quantities for screening and synthesis workflows.
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | C22H26N2O7 | 10MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon (CRBN) ligand supplied as a solid research reagent for use in PROTAC design and chemical biology studies. It has molecular formula C22H26N2O7, molecular weight 430.45 g/mol, and a reported purity of 97.44%.
- Used as a cereblon E3 ligase recruiting moiety in PROTAC synthesis.
- White to off-white solid suitable for laboratory handling.
- Reported purity of 97.4% for research applications.
- Storage guidance provided for long-term and in-solvent conditions.
- Available in small research quantities for assay development.
- For research use only; not for human or clinical use.