Lactams
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97.9% | 441.86 g·mol⁻1 | C19H24ClN3O7 | 5 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a PEG3 linker terminating in a primary amine. Supplied as the hydrochloride salt, it is intended as a building block for PROTAC design and bioconjugation chemistry.
- Contains a PEG3 linker with a terminal primary amine for conjugation.
- Supplied as hydrochloride salt to aid handling and stability.
- Intended for use as an E3 ligase recruiting ligand in PROTAC synthesis.
- High reported purity suitable for research applications.
- Available in small research sizes for medicinal chemistry workflows.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g/mol | C13H10N2O5 | 5 G
Thalidomide-4-OH is a 4-hydroxylated thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein degradation research. It is commonly used as a building block in PROTAC design and medicinal chemistry studies and is supplied as a solid for laboratory research use only.
- Acts as a cereblon (CRBN) ligand suitable for PROTAC synthesis.
- 4-hydroxyl substitution enables linker attachment for conjugation.
- High purity supports reproducible conjugation and biological assays.
- Solid form allows convenient storage and handling.
- Useful for ligand optimization and E3 ligase recruitment studies.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 500 MG
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker. It can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 g·mol⁻¹ | C13H9BrN2O4 | 200 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a research compound that engages bromodomains and cereblon-related E3 ligase biology. It is applied in studies of inflammation, tumor biology, and neurology and is supplied as a high-purity solid with recommended cold storage for powder and solutions.
- Engages bromodomains and E3 ligase pathways.
- Used in inflammation, tumor, and neurology research.
- Reported purity approximately 99.6% (COA/product listings).
- Solid, off-white to gray physical form.
- Storage: powder at -20°C (long term) or 4°C (short term); solutions at -80°C or -20°C.
- Available in small-scale amounts and DMSO solution formats.
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 98.0% | 353.76 g/mol | C15H16ClN3O5 | 10 MG
Thalidomide-5-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt. It is used as an E3 ligase ligand-linker conjugate in targeted protein degradation research and PROTAC synthesis, enabling the attachment of linkers or functional groups to the thalidomide scaffold for chemical biology applications.
- High reported purity, 98.0%.
- Supplied as the hydrochloride salt for improved handling.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable for PROTAC synthesis and ligand-linker conjugation.
- Characterized by CAS 2694727-89-2 and molecular weight 353.76 g/mol.
- Available in small research pack sizes such as 10 MG.
![Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294895.png-250.jpg)
Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG
DDL-357 is a small-molecule secreted clusterin (sCLU) enhancer used as a research probe to increase sCLU levels in brain, reduce pathological phospho-tau, and improve memory in Alzheimer's disease mouse models. It is supplied as a 10 mg research sample intended for preclinical and in vitro studies.
- Potent secreted clusterin enhancer that increases sCLU in brain.
- Reduces phospho-tau and improves cognitive performance in murine 3xTg-AD models.
- Suitable for preclinical in vivo and in vitro research applications.
- Provided as a 10 mg research sample with 98.3% purity.
- Molecular weight 440.95; molecular formula C22H21ClN4O2S; CAS 3077900-08-1.
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.26 g/mol | C15H12N2O7 | 5 G
Thalidomide-O-COOH is a thalidomide-derived carboxylic acid used as a cereblon (CRBN) ligand building block in PROTAC design and E3 ligase recruitment studies. It is supplied as a high-purity research chemical in small laboratory pack sizes for medicinal chemistry and chemical biology applications.
- Thalidomide-derived cereblon ligand for PROTAC design.
- Carboxylic acid functionality enables linker attachment and derivatization.
- Supplied as a solid suitable for standard laboratory storage.
- Provided in small research pack sizes for synthesis and assay development.
- High reported purity supports use in chemical biology experiments.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 10 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in PROTAC degraders and other bifunctional molecules. It is supplied as a high-purity solid reagent intended for research and chemical biology applications.
- High purity solid (99.96%).
- Molecular weight 276.22 g/mol.
- Molecular formula C13H9FN2O4.
- Available in laboratory pack sizes, including 10 G.
- Storage: powder at -20°C for long-term, 4°C for shorter term; in solvent store at -80°C.
Medchemexpress LLC Thalidomide-5-O-C10-NH2 hydrochloride | 99.4% | 465.97 g/mol | C23H32ClN3O5 | 10 MG
Thalidomide-5-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for chemical biology research. It is used to recruit the CRBN E3 ubiquitin ligase in PROTAC and conjugate applications to enable targeted protein ubiquitination and degradation. Molecular formula C23H32ClN3O5; molecular weight 465.97 g/mol.
- Used as a cereblon-binding ligand for PROTAC and conjugate design.
- Supplied as the hydrochloride salt for improved handling and stability.
- High purity suitable for research applications.
- Available in small research pack sizes for synthesis and screening.
- Provides a chemical handle designed for linker attachment to target ligands.
