Lactams
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 100 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, along with a linker. This compound is instrumental in designing PROTACs, which are molecules engineered to degrade specific target proteins. It functions by recruiting the E3 ubiquitin ligase to the target protein, leading to its ubiquitination and subsequent proteasomal degradation.
- Includes a ligand for an E3 ubiquitin ligase.
- Features a linker component.
- Used for the development of protein degraders.
- Purity of 99.30%.
- Available in solid form, white to off-white in color.
- Suitable for research purposes.
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.86% | 394.85 | 25 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Purity of 99.86%
- Inhibits Cereblon
- Utilizes PROTAC technology for targeted protein degradation
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | 634.67 | C30H42N4O11 | 5 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate containing a PEG3 spacer and a Boc-protected terminal amine. Supplied as a white to off-white solid at high purity, it is designed for use as a building block in PROTAC synthesis and targeted protein degradation research, enabling modular assembly of cereblon-recruiting degraders.
- Thalidomide-based cereblon ligand useful for recruiting E3 ligase.
- Peg3 linker provides a flexible spacer for conjugation to target ligands.
- Boc-protected terminal amine enables orthogonal deprotection and coupling chemistry.
- High purity suitable for synthetic and medicinal chemistry applications.
- Available in small-mass pack sizes for discovery and early-stage research.
Medchemexpress LLC N-me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 | C14H11FN2O4 | 250 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-based cereblon (E3 ligase) ligand used in PROTAC design and in the synthesis of related research compounds. Supplied as a characterized solid for research use, the compound is accompanied by analytical data and safety documentation to support laboratory workflows.
- High purity (99.4%) suitable for research applications.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 Da.
- Available in multiple pack sizes from 250 mg to 10 g.
- Analytical documentation: COA, HNMR, and RP-HPLC provided.
- Safety documentation: SDS and handling instructions available.
- Designed for use as a cereblon ligand in PROTAC conjugation chemistry.
Medchemexpress LLC Thalidomide-o-amido-c3-cooh | 2308035-51-8 | MFCD31560483 | >95.0% | 417.4 g/mol | C19H19N3O8 | 500 MG
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a three-carbon linker terminating in a carboxylic acid. It is intended for use in PROTAC synthesis and related chemical biology research, enabling conjugation to target-binding ligands for targeted protein degradation studies.
- Synthesized E3 ligase ligand-linker conjugate suitable for PROTAC design.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Features a C3 linker terminating in a carboxylic acid for conjugation.
- Available as a solid research-grade reagent in multiple package sizes.
- Recommended storage: 4°C under inert gas; in solvent store at -80°C for long term.
- Hazard: handle with appropriate personal protective equipment; may cause skin and eye irritation and is harmful if swallowed.
Medchemexpress LLC (R)-(+)-thalidomide | 260939 | MFCD00210220 | 99.8% | C13H10N2O4 | 10MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied for research use. It is reported to have psychomotor stabilizing properties and is used as a ligand in studies of cereblon-mediated E3 ligase interactions and related cellular pathways. Provided as a high-purity research chemical for biochemical and cellular assays.
- R-enantiomer of thalidomide for stereospecific studies.
- High purity 99.8% suitable for analytical and biological assays.
- Useful for research on cereblon and E3 ligase interactions.
- Available in milligram scales for laboratory research.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.6% | 380.78 | 50 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands via a linker to form PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Connects to ligands for protein by a linker to form PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-O-C4-NH2 hydrochloride | 2694727-93-8 | 100.0% | 381.81 g/mol | C17H20ClN3O5 | 10 MG
Thalidomide-5-O-C4-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research and PROTAC design. Supplied as a white to off-white solid in small milligram quantities, the compound functions as an E3 ligase recruiting moiety that can be connected to target ligands via linkers for targeted protein degradation studies.
- High purity suitable for research applications (reported ~99.98%).
- Acts as a cereblon-binding ligand for E3 ligase recruitment.
- Designed for PROTAC synthesis and linker conjugation.
- Available in small milligram pack sizes for screening and synthesis.
- Solid form, white to off-white, stable under recommended storage.
- Includes CAS number 2694727-93-8 for unambiguous identification.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 100 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- High purity of 99.64%.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 100 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only and not intended for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes linker used in PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (TFA) | 2097509-36-7 | 99.1% | 50 MG
Thalidomide-PEG2-C2-NH2 (TFA) is a chemical compound characterized by its solid, light yellow to yellow appearance. With a molecular weight of 518.44 and a high purity of 99.1% (HPLC), this product is designated for laboratory chemical applications, substance manufacturing, and general research purposes. It requires specific storage conditions to ensure its stability and effectiveness.
- High purity (99.1% by HPLC)
- Solid form
- Suitable for laboratory chemical and research applications
- Requires cold storage to maintain integrity