Lactams
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
eMolecules 17557-84-5 | 3-Azetidinone HCl | Ambeed | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 100g | 525113619
3-Azetidinone HCl | Ambeed | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 100g | 525113619
![Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244271.png-250.jpg)
Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 1 ML
ACY-957 is an orally active, selective small-molecule inhibitor of histone deacetylases HDAC1 and HDAC2 used in preclinical research to modulate epigenetic regulation and induce fetal hemoglobin expression. Reported IC50 values are 7 nM (HDAC1), 18 nM (HDAC2), and 1,300 nM (HDAC3). Supplied for in vitro and in vivo studies.
- Selective inhibition of HDAC1 and HDAC2 with low-nanomolar potency.
- Demonstrated activity in cellular models of globin gene induction.
- Orally active in preclinical pharmacology studies.
- Suitable for both in vitro and in vivo research applications.
- Characterized with vendor-provided purity and analytical data.
Medchemexpress LLC N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide | 1609389-52-7 | MFCD30342405 | 99.6% | 429.54 g·mol⁻¹ | C24H23N5OS | 25 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2 used in preclinical research. It potently inhibits HDAC1 (IC50 = 7 nM) and HDAC2 (IC50 = 18 nM), with substantially weaker activity against HDAC3 (IC50 = 1,300 nM), and shows no significant inhibition of HDAC4-HDAC9. The compound is provided as a purified research reagent for biochemical and cellular studies of epigenetic regulation.
- Potent HDAC1 inhibition (IC50 = 7 nM).
- Selective for HDAC1/2 over HDAC3 (IC50 HDAC2 = 18 nM; HDAC3 = 1,300 nM).
- Orally active profile reported in preclinical studies.
- Suitable for biochemical and cellular assays investigating epigenetic regulation.
- High chemical purity for reproducible experimental results.
Sigma Aldrich Fine Chemicals Biosciences 7-Aminodesacetoxycephalosporanic acid | 22252-43-3 | MFCD09750368 | 1G
7-Aminodesacetoxycephalosporanic acid | Mol Wt: 214.24 | 22252-43-3 | MFCD09750368 | 1G
![eMolecules 16084-57-4 | 3-Azabicyclo[3.2.0]heptane hydrochloride | Synthonix | MFCD22573703 | 133.620 | C6H12ClN | 97.000 | Cl.C1CC2CNCC12 | 1g | 532174148](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000472055.jpg-250.jpg)
eMolecules 16084-57-4 | 3-Azabicyclo[3.2.0]heptane hydrochloride | Synthonix | MFCD22573703 | 133.620 | C6H12ClN | 97.000 | Cl.C1CC2CNCC12 | 1g | 532174148
3-Azabicyclo[3.2.0]heptane hydrochloride | Synthonix | 16084-57-4 | MFCD22573703 | 133.620 | C6H12ClN | 97.000 | Cl.C1CC2CNCC12 | 1g | 532174148
Selleck Chemical LLC Tazobactam S3077-500mg
Tazobactam (Tazobactam acid Tazobactamum) is a -lactamases Inhibitor with antibacterial activity It also inhibits the class D oxacillinase OXA-2 It is used in combination with piperacillin and other -lactam antibiotics to broaden their spectrum and enhance their effect
Apexbio Technology LLC Sulbactam sodium,100mg CAS# 69388-84-7
Sulbactam sodium. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Sulbactam 68373-14-8 100mg
Sulbactam (CAS 68373-14-8) is a small-molecule inhibitor targeting bacterial -lactamase enzymes It is designed to inhibit -lactamase-mediated hydrolytic inactivation of -lactam antibiotics thereby enhancing antibiotic stability and efficacy Sulbactam exerts its biological activity primarily through competitive irreversible inhibition by covalently binding to the -lactamase active site Experimental studies report an IC50 value in the low micromolar range for inhibition of various bacterial -lactamase enzymes Based on these pharmacological properties Sulbactam holds research potential in investigating resistance mechanisms to -lactam antibiotics assessing combined therapeutic regimens and exploring novel clinical strategies for infections caused by -lactamase-producing pathogens
Medchemexpress LLC Tazobactam sodium | 89785-84-2 | 99.7% | 322.27 | 50 MG
Tazobactam sodium is an antibiotic from the beta-lactamase inhibitor class. It broadens the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides species. This product is intended for research use only and not for sale to patients.
- Causes oxidative stress and mitochondrial damage, leading to apoptosis in HK-2 cells when used with piperacillin.
- Exhibits direct nephrotoxicity, including tubular damage and mitochondrial structural alteration, in C57BL/6 mouse models.