Lactams
Medchemexpress LLC Thalidomide-5-o-c9-nh2 hydrochloride | 99.6% | 451.94 g·mol⁻1 | C22H30ClN3O5 | 10 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research. Supplied as the hydrochloride salt, it is used as an E3 ligase recruiting moiety in PROTACs and related conjugates. The product is reported with molecular formula C22H30ClN3O5 and molecular weight 451.94 g·mol⁻1.
- High purity: 99.6%.
- Hydrochloride salt form for improved handling and solubility.
- Designed for recruitment of cereblon (CRBN) in PROTAC construction.
- Suitable for synthesis, assay development, and linker conjugation.
- Available in small research pack sizes for laboratory use.
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 50 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients. The product appears as an off-white to light yellow solid with a molecular weight of 473.52.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Linker used in PROTAC technology
- For research use only
- Appears as an off-white to light yellow solid
- Molecular weight of 473.52
Medchemexpress LLC Thalidomide-5-PEG6-NH2 hydrochloride | 574.02 g/mol | C25H36ClN3O10 | 10 MG
Thalidomide-5-PEG6-NH2 hydrochloride is a thalidomide-derived cereblon ligand designed as a synthetic building block for targeted protein degradation research. The molecule includes a PEG6 linker terminating in a primary amine (hydrochloride salt) that enables conjugation to linkers or target ligands for PROTAC construction. Storage and handling conditions are provided to maintain stability.
![Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259258.png-250.jpg)
Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG
Thalidomide-piperazine-Boc is a Boc-protected piperazine derivative of thalidomide used as a synthetic intermediate for assembling E3 ligase ligand-linker conjugates such as PROTACs. It is supplied as a high-purity research reagent with defined solubility and storage recommendations.
- High purity (98.8%).
- Boc-protected piperazine for linker attachment.
- Soluble in DMSO (~41.7 mg/mL) with ultrasonic assistance.
- Powder stable at -20°C for long-term storage; solvent storage recommendations apply.
- Intended for research use only.
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | MFCD30290642 | 99.9% | 272.26 g·mol-1 | C14H12N2O4 | 5 MG
Thalidomide-5-methyl is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase subunit in chemical biology and targeted protein degradation applications. It is provided as a research-grade small molecule suitable for use as a CRBN-binding moiety in PROTAC synthesis.
- Cereblon (CRBN) ligand for recruiting E3 ligase in PROTAC design.
- High purity suitable for research applications (99.87%).
- Molecular formula C14H12N2O4 and molecular weight 272.26 g·mol-1.
- Supplied in milligram-scale quantities for synthesis and assay development.
- Useful as a modular CRBN-binding building block in chemical biology experiments.
Medchemexpress LLC Thalidomide-O-PEG2-propargyl | 2098487-52-4 | 98.3% | 400.38 | 100 MG
Thalidomide-O-PEG2-propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Contains 2-unit PEG linker
- Used in PROTAC technology
- Click chemistry reagent with an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
eMolecules 2743434-24-2 | Medchem Express | Thalidomide-5-PEG4-NH2 (hydrochloride) | 5mg | 778475789 | HY-138785A | 485.92 | C21H28ClN3O8
AstaTech | 1-(4-BROMOPHENYL)PIPERAZINE | 1g | 302795728 | 28586 | 97.000 | 66698-28-0 | MFCD00130198 | 241.132 | C10H13BrN2
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