Lactams
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 (diTFA) | 2984178-51-8 | 99.4% | 657.52 | 25 MG
Thalidomide-Piperazine-PEG1-NH2 (diTFA) is a chemical compound suitable for laboratory research. It is stable under recommended storage conditions and is not classified as a hazardous substance.
- Molecular formula: C25H29F6N5O9
- Molecular weight: 657.52
- Purity: 99.4%
- Appearance: White to yellow solid
- Storage conditions: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC Thalidomide-Piperazine-Piperidine hydrochloride | 2599846-44-1 | 98.41% | 461.94 | 25 MG
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Incorporates thalidomide based cereblon ligand
- Utilizes a linker used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-NH2-CH2-COOH | 2412056-27-8 | 95.0% | C15H13N3O6 | 500 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (Trk) and a ligand of E3 ligase. It has potential for researching various diseases, as extracted from patent WO2021170109A1.
- Potent and selective Trk inhibitor
- Ligand of E3 ligase
- Researches various diseases including cancer, inflammation, and neurodegenerative conditions
- Solid appearance
- Color can range from light yellow to green yellow
Medchemexpress LLC Fc epsilon RIA/FCER1A protein, mouse (HEK293, C-hFc) | >85.0% | 5 UG
Recombinant mouse Fc epsilon RI alpha (FCER1A) extracellular domain fused to a C-terminal human Fc, expressed in HEK293 cells and supplied lyophilized. Intended for immunoassays, binding studies, and functional assays involving IgE-FcεRI interactions; documentation including datasheet and COA is available.
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 25 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. This compound is suitable for designing PROTACs.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase
- Contains a linker
- Suitable for designing PROTACs
- Relevant to cancer targeted therapy, cancer metabolism, and metastasis
- Related to PROTAC research
- Involved in autophagy studies
- Used in apoptosis research
- Applicable to E3 ligase ligand-linker conjugates
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97% | 441.86 | 1 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It has an IC 50 of Cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Solid form
- White to off-white color
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 704.72 | 100 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | >96.5% | 360.34 | 5 G
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate. Its intended use is for research purposes, specifically in the field of PROTAC (Proteolysis Targeting Chimeras) technology. It incorporates a thalidomide-based cereblon ligand and a linker. This product is not for sale to patients.
- Appearance: Solid, light yellow to green yellow
- Solubility: Soluble in DMSO (5.83 mg/mL or 16.18 mM)
- Storage: 4°C, protect from light; in solvent: -80°C for 6 months, -20°C for 1 month (protect from light)
- Related research areas: Cancer, PROTAC, autophagy, apoptosis, E3 ligase ligand-linker conjugates
- Cereblon ligand: Incorporates a thalidomide-based cereblon ligand
- PROTAC technology: Utilizes a linker commonly used in PROTAC technology
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 | 25 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.85% | 522.08 | 25 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand that is used in the recruitment of CRBN protein. It can be linked to a protein ligand to create PROTACs. It is for research use only.
- Functions as a ligand for E3 Ligase.
- Involved in the recruitment of CRBN protein.
- Can be connected via a linker to a protein ligand to form PROTACs.
- Intended for research use only.
Medchemexpress LLC Laurocapram | 59227-89-3 | 281.48 | 1 ML
Laurocapram is a chemical penetration enhancer that increases the permeability of compounds through the skin and mucous membranes, improving their local or systemic efficacy. It enhances the skin permeability of various hydrophilic and lipophilic compounds. This product is provided as a 10 mM solution in 1 mL, suitable for research applications.
- Increases permeability of compounds through skin and mucous membranes.
- Improves local or systemic efficacy of compounds.
- Enhances skin permeability for both hydrophilic and lipophilic compounds.
- Synergizes with β-lactam antibiotics to improve antibacterial activity against S. aureus.
- Exhibits anti-infectious activity in MRSA-induced mouse pneumonia models.
- Ameliorates infection wounds in MRSA-administrated mouse skin infection models.
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00078028 | 99.98% | 258.23 | 500 MG
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of approximately 250 nM. It possesses immunomodulatory, anti-inflammatory, and anti-angiogenic cancer properties. Thalidomide can also function as a molecular glue to potentiate substrate.
- Inhibits cereblon (CRBN), a component of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.
- Demonstrates immunomodulatory, anti-inflammatory, and anti-angiogenic properties.
- Functions as a molecular glue to potentiate substrate.
- Potentiates the anti-tumor activity of Icotinib against PC9 and A549 cell proliferation.
- Inhibits EGFR and VEGF-R2 pathways in PC9 cells.
- Alleviates RILF by suppressing ROS and down-regulating the TGF-β/Smad pathway.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 25 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- 2-unit PEG linker
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins