Lactams
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 hydrochloride | 2376990-31-5 | 99.3% | 466.92 | 100 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand and a linker
- Used in the synthesis of PROTACs
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Tz-thalidomide (tetrazine tagged thalidomide) | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 50 MG
Tz-thalidomide is a tetrazine-tagged derivative of thalidomide designed for research applications in click chemistry and targeted protein degradation. It is supplied as a pink to red solid with high purity and is formulated for solubility in DMSO for in vitro use.
- Tetrazine-functionalized thalidomide scaffold for iEDDA click reactions.
- High purity (98.6%) suitable for biochemical assays.
- Solid, pink to red form that is stable under recommended storage conditions.
- Good solubility in DMSO (50 mg/mL) for stock preparation.
- Available in small research quantities compatible with probe synthesis.
- Applicable as an E3 ligase ligand for PROTAC and molecular-glue studies.
Medchemexpress LLC 6h-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6s)- | 3077900-08-1 | 98.31% | 440.95 | 1 ML
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Potent secreted clusterin enhancer.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | MFCD34180776 | 99.4% | 355.12 g·mol⁻1 | C13H8BrFN2O4 | 25 MG
Thalidomide-4-F,5-Br is a halogenated thalidomide analogue that functions as an E3 ligase recruiting ligand for targeted protein degradation research. Supplied as a powder in small pre-weighed quantities, it is intended for research use in PROTAC development and studies of ubiquitin-mediated proteolysis.
- Halogenated thalidomide derivative (fluoro and bromo substitutions).
- Acts as a cereblon (CRBN) E3 ligase recruiting ligand for PROTAC applications.
- High purity suitable for research (approximately 99.4%).
- Provided as a powder for easy handling and formulation.
- Available in small pre-weighed quantities for screening and synthesis workflows.
![eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475321.JPG-250.jpg)
eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6
Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6
Medchemexpress LLC Thalidomide-5 6-F 1g
Thalidomide-5 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein Thalidomide-5 6-F can be connected to the ligand for protein by a linker to form PROTACs[1]
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | 486.56 g·mol⁻¹ | C26H34N2O7 | 5 MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand for targeted protein degradation research. It is designed to be connected to a protein-targeting ligand via a linker to form PROTAC molecules and is provided as a research-grade chemical with manufacturer-reported purity (~95.1%).
- Acts as a cereblon ligand to recruit CRBN.
- Designed for conjugation via a linker to form PROTACs.
- Supplied at research-grade purity (~95.1%).
- Molecular formula C26H34N2O7; molecular weight 486.56 g·mol⁻¹.
- Available in milligram-scale quantities suitable for synthesis and screening.
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 100MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used to recruit the CRBN protein. It can be linked to a target protein ligand via a linker to form IMiD-containing PROTACs. It is also a click chemistry reagent containing an Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Used to recruit the Cereblon protein
- Can be linked to a target protein ligand to form IMiD-containing PROTACs
- Click chemistry reagent containing an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 500 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 2-unit PEG linker
- Utilized in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-PEG2-propargyl | 2098487-52-4 | 98.3% | 400.38 | 100 MG
Thalidomide-O-PEG2-propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Contains 2-unit PEG linker
- Used in PROTAC technology
- Click chemistry reagent with an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 100 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can be an immunomodulator for the treatment of cancer. It is for research use only and not sold to patients. PROTACs contain two different ligands connected by a linker, one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates an E3 ligase ligand and a linker
- Can be an immunomodulator for the treatment of cancer
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 2 MG
Thalidomide-propargyl is a Cereblon ligand derived from Thalidomide that facilitates the recruitment of the CRBN protein. It can be linked to other ligands to form IMiD-containing PROTACs. This compound is a click chemistry reagent, featuring an Alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Can be connected to ligands for protein to form IMiD containing PROTACs.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.