Lactams
Medchemexpress LLC Thalidomide-PEG4-COOH | 2828438-28-2 | 95.4% | 478.45 | 25 MG
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- Targets cereblon
- Associated with cancer, cancer targeted therapy, cancer metabolism, and metastasis research
- Relevant to autophagy and apoptosis studies
- Functions as an inhibitor
Medchemexpress LLC Thalidomide-piperazine-peg1-cooh | 2731007-11-5 | 99.2% | 458.46 | 50 MG
Thalidomide-Piperazine-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 98.0% | 353.76 g/mol | C15H16ClN3O5 | 10 MG
Thalidomide-5-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt. It is used as an E3 ligase ligand-linker conjugate in targeted protein degradation research and PROTAC synthesis, enabling the attachment of linkers or functional groups to the thalidomide scaffold for chemical biology applications.
- High reported purity, 98.0%.
- Supplied as the hydrochloride salt for improved handling.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable for PROTAC synthesis and ligand-linker conjugation.
- Characterized by CAS 2694727-89-2 and molecular weight 353.76 g/mol.
- Available in small research pack sizes such as 10 MG.
![Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294895.png-250.jpg)
Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG
DDL-357 is a small-molecule secreted clusterin (sCLU) enhancer used as a research probe to increase sCLU levels in brain, reduce pathological phospho-tau, and improve memory in Alzheimer's disease mouse models. It is supplied as a 10 mg research sample intended for preclinical and in vitro studies.
- Potent secreted clusterin enhancer that increases sCLU in brain.
- Reduces phospho-tau and improves cognitive performance in murine 3xTg-AD models.
- Suitable for preclinical in vivo and in vitro research applications.
- Provided as a 10 mg research sample with 98.3% purity.
- Molecular weight 440.95; molecular formula C22H21ClN4O2S; CAS 3077900-08-1.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Acetamide, n-(4-azidobutyl)-thalidomide derivative | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 50 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived E3 ligase (cereblon) ligand-linker conjugate containing an azide functional group for bioconjugation. It is used as a click-chemistry reagent and building block in targeted protein degradation (PROTAC) research. The compound has defined solubility profiles for in vitro and in vivo formulations and is supplied with storage recommendations for stability.
- Contains an azide group for CuAAc and SPAAC click reactions.
- Functions as a cereblon (CRBN) recruiter in PROTAC constructs.
- High purity verified by LCMS (98.36%).
- Good solubility in DMSO (≥ 41 mg/mL) and formulatable for in vivo use (≥ 2.5 mg/mL).
- Storage recommendations: 4°C under nitrogen; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-4-F,5-Br | 2740657-28-5 | 99.4% | 355.12 g·mol⁻¹ | C13H8BrFN2O4 | 50 MG
Thalidomide-4-F,5-Br is a thalidomide analogue used as a cereblon (CRBN) E3 ligase ligand in biochemical research. It is provided as a purified powder for use in degradation studies, PROTAC design, and related cell biology and biochemical assays.
- Acts as a cereblon E3 ligase ligand for targeted protein ubiquitination and degradation.
- Suitable for PROTAC synthesis and biochemical assay development.
- Supplied as a powder form for convenient handling and storage.
- High purity (~99%) suitable for research applications.
- Molecular weight approximately 355.12 g·mol⁻¹.
- Available in multiple small package sizes for laboratory use.
Medchemexpress LLC N-me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 | C14H11FN2O4 | 250 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-based cereblon (E3 ligase) ligand used in PROTAC design and in the synthesis of related research compounds. Supplied as a characterized solid for research use, the compound is accompanied by analytical data and safety documentation to support laboratory workflows.
- High purity (99.4%) suitable for research applications.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 Da.
- Available in multiple pack sizes from 250 mg to 10 g.
- Analytical documentation: COA, HNMR, and RP-HPLC provided.
- Safety documentation: SDS and handling instructions available.
- Designed for use as a cereblon ligand in PROTAC conjugation chemistry.
Medchemexpress LLC (R)-(+)-thalidomide | 260939 | MFCD00210220 | 99.8% | C13H10N2O4 | 10MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied for research use. It is reported to have psychomotor stabilizing properties and is used as a ligand in studies of cereblon-mediated E3 ligase interactions and related cellular pathways. Provided as a high-purity research chemical for biochemical and cellular assays.
- R-enantiomer of thalidomide for stereospecific studies.
- High purity 99.8% suitable for analytical and biological assays.
- Useful for research on cereblon and E3 ligase interactions.
- Available in milligram scales for laboratory research.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-5-O-C4-NH2 hydrochloride | 2694727-93-8 | 100.0% | 381.81 g/mol | C17H20ClN3O5 | 10 MG
Thalidomide-5-O-C4-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research and PROTAC design. Supplied as a white to off-white solid in small milligram quantities, the compound functions as an E3 ligase recruiting moiety that can be connected to target ligands via linkers for targeted protein degradation studies.
- High purity suitable for research applications (reported ~99.98%).
- Acts as a cereblon-binding ligand for E3 ligase recruitment.
- Designed for PROTAC synthesis and linker conjugation.
- Available in small milligram pack sizes for screening and synthesis.
- Solid form, white to off-white, stable under recommended storage.
- Includes CAS number 2694727-93-8 for unambiguous identification.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 100 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- High purity of 99.64%.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only