Lactams
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | C21H20N2O8 | 10MG
Thalidomide-Propargyne-PEG2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate designed for use in PROTAC development and bioconjugation workflows. It incorporates a CRBN-binding thalidomide core, a short PEG2 spacer, and a terminal propargyne for click chemistry; supplied as a solid with high reported purity and good DMSO solubility.
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | 430.45 g/mol | C22H26N2O7 | 5 MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon ligand with a carboxy-terminated eight-carbon linker, developed for use as an E3 ligase recruiter in targeted protein degradation. It is provided as a high-purity solid optimized for conjugation into PROTACs and other bifunctional degraders, with documented solubility and storage recommendations for research workflows.
- High purity (97.4%) suitable for research applications.
- Carboxy-terminated C8 linker for convenient coupling chemistry.
- Molecular weight 430.45 g/mol; formula C22H26N2O7.
- High solubility in DMSO for preparation of concentrated stock solutions.
- Storage and solvent stability data provided for reliable handling.
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | C24H30N4O8 | 10MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a PEG2-containing piperazine linker. It is intended for use in proteolysis-targeting chimera (PROTAC) research and supports conjugation via a terminal carboxylic acid for downstream coupling.
- High purity suitable for research applications.
- Contains a carboxylic acid functional group for facile coupling.
- Designed to recruit the cereblon E3 ligase in degrader constructs.
- PEG2 linker provides short, flexible spacer for conjugation.
- Characterized by molecular formula C24H30N4O8 and molecular weight 502.52 g·mol⁻¹.
![Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259258.png-250.jpg)
Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG
Thalidomide-piperazine-Boc is a Boc-protected piperazine derivative of thalidomide used as a synthetic intermediate for assembling E3 ligase ligand-linker conjugates such as PROTACs. It is supplied as a high-purity research reagent with defined solubility and storage recommendations.
- High purity (98.8%).
- Boc-protected piperazine for linker attachment.
- Soluble in DMSO (~41.7 mg/mL) with ultrasonic assistance.
- Powder stable at -20°C for long-term storage; solvent storage recommendations apply.
- Intended for research use only.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
Medchemexpress LLC Thalidomide-5-peg2-cl | 2230956-57-5 | 96.6% | C17H17ClN2O6 | 10MG
Thalidomide-5-PEG2-Cl is a thalidomide-derived cereblon (CRBN) ligand featuring a short PEG2 spacer and a terminal chloride. It is supplied as a research-grade building block for conjugation in PROTAC design and other CRBN-targeting chemical biology applications, with documented molecular formula and purity.
- Provides a CRBN-recruiting moiety suitable for PROTAC assembly.
- Contains a PEG2 linker for flexible conjugation to ligands.
- Terminal chloride enables straightforward chemical derivatization.
- Supplied with referenced purity and characterization data.
- Available in small research-friendly pack sizes for early-stage work.
Medchemexpress LLC Thalidomide | 50-35-1 | MFCD00153873 | 100.0% | C13H10N2O4 | 10MG
Thalidomide (analytical standard) is a high-purity reference compound (CAS 50-35-1) intended for research and analytical applications. It serves as a cereblon inhibitor standard for assay calibration, method development, and reference testing. Consult the certificate of analysis and safety data sheet for batch-specific purity and handling instructions.
- High purity (99.96%) suitable for analytical standards.
- Provided in small, laboratory-scale quantities for method development.
- Supplied with certificate of analysis and safety data sheet.
- Intended for research and analytical use only.
- Suitable for assays targeting cereblon-related activity.
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
Medchemexpress LLC Thalidomide-piperazine-PEG1-COOH | 2731007-11-5 | 99.2% | 458.46 | 25 MG
Thalidomide-Piperazine-PEG1-COOH is a synthetic E3 ligase ligand-linker coupler containing a Thalidomide-based ligand and one linker. It acts as an E3 ligase ligand-linker conjugate.
- E3 ligase ligand-linker coupler
- Contains a Thalidomide-based ligand and one linker
![Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259722.png-250.jpg)
Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG
Thalidomide-4-O-C10-COOH is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate provided for research use as a synthetic intermediate in the preparation of proteolysis-targeting chimeras (PROTACs). The molecule features a ten-carbon linker terminating in a carboxylic acid, and is supplied as a solid with formula C24H30N2O7 and molecular weight 458.50 g·mol⁻¹.
- Thalidomide-based cereblon (CRBN) ligand-linker conjugate.
- Suitable for PROTAC synthesis and E3 ligase recruitment studies.
- Contains a C10 linker with a terminal carboxylic acid for conjugation.
- High reported purity (99.1%).
- Supplied as a solid; molecular formula C24H30N2O7, molecular weight 458.50 g·mol⁻¹.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 50 MG
Thalidomide-NH-C4-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker, used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets cereblon
- Solid appearance
- Color: yellow to green
- For research use only
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Cayman Chemical -ThalIdomIde 100mg
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling