Lactams
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g·mol⁻1 | C19H21BN2O6 | 25 MG
Thalidomide-pinacolborane is a thalidomide-derived boronic pinacol ester used as a cereblon (CRBN) ligand for E3 ligase recruitment in PROTAC design and for synthetic transformations such as Suzuki cross-coupling. It is supplied as a solid research reagent intended for use in ligand design, chemical synthesis, and targeted protein degradation studies.
- Contains boronic pinacol ester (Bpin) functionality for Suzuki coupling.
- Functions as a cereblon E3 ligase ligand suitable for PROTAC applications.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g·mol⁻1.
- CAS number 2229725-98-6.
- Purity 97.0% as listed by the supplier.
- Provided as a 25 MG research pack.
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 25 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Targets cereblon
- Molecular weight: 444.48
- Chemical formula: C22H28N4O6
- Appearance: Solid
- Color: Yellow to green
- Solubility in DMSO: 100 mg/mL (224.98 mM)
- Shipping at room temperature in continental US
- Storage at 4°C, protected from light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (protected from light)
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.19% | C25H32N6O10 | 100 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilizing this linker are engineered to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent with Azide group
- Enables CuAAc reactions with alkyne groups
- Facilitates SPAAC reactions with DBCO or BCN groups
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 g/mol | C15H12N2O7 | 50 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate for the synthesis of PROTAC molecules. Supplied as a solid with supplier-characterized purity, it is intended for research applications in targeted protein degradation.
- Acts as a cereblon ligand for targeted protein degradation research.
- Suitable intermediate for PROTAC synthesis and conjugation chemistry.
- Approximately 95.0% purity, characterized by supplier analytical data.
- Solid form, light yellow to brown appearance for easy handling.
- Good solubility in DMSO for in vitro formulation and assays.
- Stable when stored under recommended conditions for long-term use.
![Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259258.png-250.jpg)
Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG
Thalidomide-piperazine-Boc is a Boc-protected piperazine derivative of thalidomide used as a synthetic intermediate for assembling E3 ligase ligand-linker conjugates such as PROTACs. It is supplied as a high-purity research reagent with defined solubility and storage recommendations.
- High purity (98.8%).
- Boc-protected piperazine for linker attachment.
- Soluble in DMSO (~41.7 mg/mL) with ultrasonic assistance.
- Powder stable at -20°C for long-term storage; solvent storage recommendations apply.
- Intended for research use only.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | MFCD32643096 | 99.3% | 388.37 | C19H20N2O7 | 10 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a tert-butyl protected thalidomide derivative used as a cereblon (CRBN) binding ligand and as a synthetic intermediate in the preparation of PROTAC molecules. It is supplied for research use only and is not intended for human use.
- Tert-butyl protected thalidomide derivative suitable for deprotection under acidic conditions.
- Functions as a cereblon (CRBN) binding ligand for use in PROTAC design.
- High reported purity (~99.3%) for reliable research applications.
- Available in small research pack sizes (mg scale) for synthetic workflows.
- Stable at room temperature for extended storage; follow solvent storage recommendations for longer-term stability.
Medchemexpress LLC Thalidomide-PEG5-NH2 hydrochloride | 2703775-06-6 | MFCD34550803 | 95.2% | 529.97 g·mol⁻¹ | C23H32ClN3O9 | 5 MG
Thalidomide-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) binding moiety with a PEG5 amine linker, supplied as the hydrochloride salt. It is intended for use in PROTAC design and chemical biology research involving CRBN-mediated protein degradation.
- Cereblon-binding thalidomide-derived ligand.
- PEG5 amine linker provides a flexible spacer for conjugation.
- Hydrochloride salt improves solubility and handling.
- Characterized by CAS 2703775-06-6 and molecular weight 529.97 g·mol⁻¹.
- Purity approximately 95.2% by LCMS.
- Intended for research use in targeted protein degradation studies.
Medchemexpress LLC Thalidomide O-amido C3-COOH | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 50 MG
Thalidomide O-amido C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a short linker terminating in a carboxylic acid. It is provided as a research-grade chemical for use in PROTAC design and related chemical biology applications.
- Contains thalidomide-based cereblon ligand
- Three-carbon (C3) linker with terminal carboxylic acid
- Molecular formula C19H19N3O8; molecular weight 417.37 g/mol
- Purity 98.4% (research grade)
- Supplied as a white solid suitable for chemical synthesis
- Intended for research use only, not for human or clinical use
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 25 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker that is utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Utilizes PROTAC technology
- Incorporates Thalidomide based cereblon ligand
- Intended for research use only
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | C22H27N3O9 | 5 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a carboxylic acid. It is intended as a modular building block for PROTAC development to recruit CRBN and enable linker attachment to target-binding ligands.
- Designed for PROTAC assembly and CRBN recruitment.
- Contains a PEG3 linker terminating in a carboxylic acid for facile conjugation.
- Incorporates a thalidomide-based cereblon ligand.
- High chemical purity (≈98.9%).
- Suitable for medicinal chemistry and chemical biology applications.
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 100 MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This molecule is designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets E3 Ligase Ligand-Linker Conjugates, Apoptosis, and Autophagy
- Targets Cereblon with an IC50 & Target affinity
- Molecular weight of 578.61
Medchemexpress LLC Thalidomide-Piperazine-Piperidine hydrochloride | 2599846-44-1 | 98.41% | 461.94 | 25 MG
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Incorporates thalidomide based cereblon ligand
- Utilizes a linker used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 (TFA) | 2097509-49-2 | 514.49 g/mol | C23H29F3N4O6 | 10 MG
Thalidomide-5-NH2-C8-NH2 (TFA) is a thalidomide-derived intermediate provided as the trifluoroacetic acid salt for research use and compound synthesis. It is intended for laboratory applications only and should be handled using appropriate safety procedures; store sealed at -20°C away from moisture and light. In solvent, recommended storage is -80°C for up to 6 months or -20°C for up to 1 month.
- Salt form: trifluoroacetic acid (TFA) salt.
- Suitable for compound synthesis and as a building block.
- Molecular formula: C23H29F3N4O6.
- Molecular weight: 514.49 g/mol.
- Storage: sealed at -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or clinical use.