Lactams

Medchemexpress LLC DDL-357 | 3077900-08-1 | 98.3% | 440.95 | 100 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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DDL-357 is a potent secreted clusterin enhancer that reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only and not sold to patients.

• Potent secreted clusterin enhancer
• Reduces phospho-tau in brain
• Improves memory in the murine 3xTg-AD model
• For research use only

Medchemexpress LLC 6h-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6s)- | 3077900-08-1 | 98.31% | 440.95 | 1 ML

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.

• Potent secreted clusterin enhancer.
• Reduces phospho-tau in brain.
• Improves memory in the murine 3xTg-AD model.

Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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DDL-357 is a small-molecule secreted clusterin (sCLU) enhancer used as a research probe to increase sCLU levels in brain, reduce pathological phospho-tau, and improve memory in Alzheimer's disease mouse models. It is supplied as a 10 mg research sample intended for preclinical and in vitro studies.

• Potent secreted clusterin enhancer that increases sCLU in brain.
• Reduces phospho-tau and improves cognitive performance in murine 3xTg-AD models.
• Suitable for preclinical in vivo and in vitro research applications.
• Provided as a 10 mg research sample with 98.3% purity.
• Molecular weight 440.95; molecular formula C22H21ClN4O2S; CAS 3077900-08-1.

Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

DDL-357 is a potent enhancer of secreted clusterin. It has been shown to reduce phospho-tau levels in the brain and improve memory in the murine 3xTg-AD model. It is intended for research use only and not for sale to patients.

• Purity: 98.31%
• Appearance: Solid
• Color: White to off-white
• Shipping: Room temperature in continental US; may vary elsewhere.
• Storage (powder): -20°C for 3 years, 4°C for 2 years.
• Storage (in solvent): -80°C for 6 months, -20°C for 1 month.
• Solubility (in vitro): 100 mg/mL in DMSO (226.78 mM; requires ultrasonic, hygroscopic DMSO affects solubility).
• Solubility (in vivo - protocol 1): ≥ 5 mg/mL (11.34 mM) in a mixture of 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, yielding a clear solution.

Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 25 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only.

• Potent secreted clusterin enhancer.
• Reduces phospho-tau in the brain.
• Improves memory in the murine 3xTg-AD model.

Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.

• Reduces phospho-tau in brain.
• Improves memory in the murine 3xTg-AD model.