Lactams

Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG

Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.

• Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
• Thalidomide-based ligand with a six-carbon carboxylic acid linker.
• High purity, 99.3% (reported).
• Soluble ≥100 mg/mL in DMSO.
• Off-white to light yellow solid suitable for synthesis.
• Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
• Storage recommendations provided for powder and solutions to maintain stability.

Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | C22H27N3O9 | 5 MG

Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a carboxylic acid. It is intended as a modular building block for PROTAC development to recruit CRBN and enable linker attachment to target-binding ligands.

• Designed for PROTAC assembly and CRBN recruitment.
• Contains a PEG3 linker terminating in a carboxylic acid for facile conjugation.
• Incorporates a thalidomide-based cereblon ligand.
• High chemical purity (≈98.9%).
• Suitable for medicinal chemistry and chemical biology applications.

Medchemexpress LLC Thalidomide O-amido C3-COOH | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 50 MG

Thalidomide O-amido C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a short linker terminating in a carboxylic acid. It is provided as a research-grade chemical for use in PROTAC design and related chemical biology applications.

• Contains thalidomide-based cereblon ligand
• Three-carbon (C3) linker with terminal carboxylic acid
• Molecular formula C19H19N3O8; molecular weight 417.37 g/mol
• Purity 98.4% (research grade)
• Supplied as a white solid suitable for chemical synthesis
• Intended for research use only, not for human or clinical use

Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 10 MG

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon ligand-linker conjugate (trifluoroacetic acid salt) designed as a building block for PROTAC synthesis. It links a thalidomide-derived E3 ligase ligand to a three-unit PEG spacer terminating in a C2 amino handle, enabling attachment to targeting ligands and facilitating cereblon-mediated target degradation.

• Thalidomide-based cereblon ligand for E3 ligase recruitment.
• Three-unit PEG linker providing flexible spacing and solubility.
• C2 amino terminal suitable for amide or urea coupling.
• Trifluoroacetic acid salt form for improved handling and stability.
• Molecular formula C25H31F3N4O11; molecular weight 620.53 g/mol.
• Soluble in DMSO at 50 mg/mL; ultrasonic may be required.
• Recommended storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
• Available in small research quantities suitable for synthesis, e.g., 10 mg.

Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | 99.0% | C20H23N3O8 | 10MG

Thalidomide-NH-PEG2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate designed as a building block for PROTAC and targeted protein degradation research. It couples a CRBN-recruiting thalidomide moiety to a short PEG2 spacer terminated with a carboxylic acid, facilitating conjugation to warheads or scaffolds for degrader design.

• Thalidomide-based cereblon ligand for CRBN recruitment.
• PEG2 linker terminated with carboxylic acid for conjugation.
• Suitable as a building block for PROTAC synthesis and linker optimization.
• High purity (99.0%) supporting reproducible conjugation chemistry.
• Molecular formula C20H23N3O8; molecular weight 433.41 g/mol.
• Supplied in small milligram pack sizes for research use.

Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG

Thalidomide-4-O-C10-COOH is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate provided for research use as a synthetic intermediate in the preparation of proteolysis-targeting chimeras (PROTACs). The molecule features a ten-carbon linker terminating in a carboxylic acid, and is supplied as a solid with formula C24H30N2O7 and molecular weight 458.50 g·mol⁻¹.

• Thalidomide-based cereblon (CRBN) ligand-linker conjugate.
• Suitable for PROTAC synthesis and E3 ligase recruitment studies.
• Contains a C10 linker with a terminal carboxylic acid for conjugation.
• High reported purity (99.1%).
• Supplied as a solid; molecular formula C24H30N2O7, molecular weight 458.50 g·mol⁻¹.
• For research use only; not for human therapeutic use.

Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | MFCD34473293 | 98.0% | 472.45 g/mol | C23H24N2O9 | 5 MG

Thalidomide-propargyne-PEG3-COOH is a thalidomide-based E3 ligase ligand-linker conjugate with a propargyl (alkynyl) handle and a PEG3 linker terminating in a carboxylic acid. Designed as a building block for PROTAC assembly and related chemical biology work, it is compatible with click chemistry and standard amide-coupling reactions. CAS 2797649-54-6; formula C23H24N2O9; MW 472.45; typical purity ~98%.

• Contains a propargyl (alkynyl) handle for CuAAC click chemistry.
• Includes a PEG3 linker terminating in a carboxylic acid for conjugation.
• Acts as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
• Suitable for amide coupling and linker attachment.
• Supplied as a solid with high purity for research use.

Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | 346.29 g/mol | C16H14N2O7 | 5 MG

Thalidomide-O-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand with a two-carbon linker. It is intended as a research-grade building block for PROTAC synthesis and related chemical biology applications, and is supplied with reported analytical data suitable for experimental use.

• E3 ligase ligand-linker conjugate for PROTAC design.
• Molecular formula C16H14N2O7.
• Molecular weight 346.29 g/mol.
• CAS number 2369068-42-6.
• Reported purity 95.0%.
• Available in small milligram pack sizes for research use.

Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.

• Provides a cereblon-binding thalidomide ligand for PROTAC design.
• Includes a PEG3 linker to improve solubility and flexibility.
• Features a C2 amine handle for facile coupling to warheads.
• Offered as the TFA salt to aid handling and stability.
• Supplied at high purity (>98%) suitable for synthetic use.
• Available in small research-scale quantities for method development.