Lactams

Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG

Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.

• High purity suitable for research applications (≈99.1%).
• Azide functional group enables copper-free and copper-catalyzed click chemistry.
• Six-carbon linker provides flexible spacing for bifunctional molecule design.
• Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
• Available in multiple small-scale quantities for synthesis and assay development.

Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | MFCD31560486 | ≥98.0% | 428.40 g·mol⁻¹ | C19H20N6O6 | 5 MG

Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate that contains an azide functional group. It is supplied as a research-grade building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs) and for click-chemistry bioconjugation, compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted azide-alkyne cycloaddition.

• Contains an azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
• Suitable for PROTAC synthesis and E3 ligase recruitment studies.
• Research-grade building block with defined molecular formula and molecular weight.
• Forms a clear solution when dissolved in common organic solvents.
• Recommended storage: store solid at 4°C under inert atmosphere; in solution -80°C for up to 6 months or -20°C for up to 1 month.

Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG

Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.

• Provides a cereblon-binding ligand for CRBN-mediated degradation
• Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
• PEG3 spacer improves solubility and linker flexibility
• Terminal carboxylic acid enables amide coupling and conjugation
• Supplied at research-grade purity suitable for synthesis

Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG

Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.

• Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
• Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
• Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
• High purity suitable for research and synthetic applications.
• Available in small pack sizes for efficient use in medicinal chemistry workflows.