Lactones
Medchemexpress LLC IFN-gamma R1/CD119 100ug
IFN-gamma R1 (CD119) one of the subunit of IFN-gamma receptor is a receptor for IFN-gamma IFN-gamma R1 forms the functional receptor with IFN-gamma R2 Upon binding with IFN-gamma IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1] Then JAK1 and JAK2 are phosphorylated and activated and STAT1 is recruited to the receptor complex Phosphorylated STAT1 translocates to the nucleus where it regulates the expression of IFN-responsive genes (e g CD54)[2] IFN-gamma R1/CD119 Protein Mouse (HEK293 His) is a recombinant mouse IFN-gamma R1 with C-terminal 6 His tag which is produced in HEK293 cells
Medchemexpress LLC Simvastatin acid ammonium | 139893-43-9 | 99.7% | 10 MG
Simvastatin acid ammonium is the ammonium salt of simvastatin acid and acts as an HMG-CoA reductase inhibitor used in biochemical and pharmacological research to study cholesterol biosynthesis and related cellular pathways. It is provided as a purified solid suitable for in vitro studies.
- High purity 99.7%
- Molecular formula C25H43NO6 and molecular weight 453.61 g/mol
- Soluble in DMSO
- Supplied as a small, research-grade quantity suitable for in vitro assays
- Used to study HMG-CoA reductase activity and cholesterol metabolism
![Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240686.png-250.jpg)
Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 10 MG
SD-1008 is a small-molecule JAK inhibitor that reduces STAT3-dependent signaling by inhibiting tyrosyl phosphorylation of STAT3, JAK2, and Src. It is supplied as a high-purity research reagent (C18H19NO5, 329.35 g/mol) intended for biochemical and cellular studies of JAK/STAT pathway modulation.
- Potent JAK/STAT pathway inhibitor.
- Reported purity 99.1%.
- Suitable for biochemical and cellular assays.
- Compact pack sizes for small-scale research use.
- Molecular formula C18H19NO5 and MW 329.35 g/mol.
Medchemexpress LLC Glucosylceramide (gaucher's spleen) | 85305-87-9 | 98% | 1 MG
Glucosylceramides are sphingolipid molecules found in both neuronal and non-neuronal mammalian tissues, as well as in low quantities across various plant species. Elevated levels of glucosylceramides provide cellular protection and prepare certain cells for proliferation; however, they have also been linked to obesity-induced insulin resistance in mice and to neuronal deficits observed in neuronopathic Gaucher disease.
- Provides cellular protection
- Prepares certain cells for proliferation
![Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241614.png-250.jpg)
Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 5 MG
SD-1008 is a small-molecule JAK inhibitor (CAS 960201-81-4) used in research to block tyrosyl phosphorylation of STAT3, JAK2, and Src and to enhance apoptosis in sensitive cell lines. It is supplied as a high-purity, solid reagent for biochemical and cellular studies.
- Potent inhibition of JAK/STAT3 signaling, reducing phosphorylation of STAT3, JAK2, and Src.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 329.35 g/mol and formula C18H19NO5 for accurate dosing.
- Light yellow solid appearance, convenient for handling and dissolution.
- Multiple package sizes available to support assay development and screening.
- Storage recommendations: protect from light, store under inert gas, and maintain cold storage for solutions.
Medchemexpress LLC Gamma tubulin antibody (YA419) (PBS only) | affinity purified | 51 kDa | 10 UL
Gamma Tubulin Antibody is a non-conjugated, rabbit-originated IgG monoclonal antibody, targeting gamma Tubulin. It can be used as a loading control antibody. This gene encodes a member of the tubulin superfamily, with the encoded protein localizing to the centrosome where it binds to microtubules as part of the gamma-tubulin ring complex. This protein mediates microtubule nucleation and is essential for microtubule formation and cell cycle progression.
- Host: Rabbit
- Reactivity: Human, Mouse, Rat, Hamster
- Conjugation: Non-conjugated
- SwissProt ID: P23258
- Research field: Signal transduction
- Application: WB, ICC/IF, IP
- Purity: Affinity purified
- Formulation: Supplied in PBS, pH 7.4
Medchemexpress LLC IFN-gamma R1/CD119 500ug
IFN-gamma R1 (CD119) one of the subunit of IFN-gamma receptor is a receptor for IFN-gamma IFN-gamma R1 forms the functional receptor with IFN-gamma R2 Upon binding with IFN-gamma IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1] Then JAK1 and JAK2 are phosphorylated and activated and STAT1 is recruited to the receptor complex Phosphorylated STAT1 translocates to the nucleus where it regulates the expression of IFN-responsive genes (e g CD54)[2] IFN-gamma R1/CD119 Protein Mouse (HEK293 His) is a recombinant mouse IFN-gamma R1 with C-terminal 6 His tag which is produced in HEK293 cells
Medchemexpress LLC Gamma-valerolactone | 108-29-2 | MFCD00005400 | 99.9% | 100.12 g/mol | C5H8O2 | 50 G
Gamma-valerolactone (5-methyldihydrofuran-2(3H)-one) is a high-purity lactone used as an analytical reference standard and biochemical reagent for life-science research and analytical applications. The compound is supplied with supporting documentation, including a certificate of analysis and safety data sheet, and is suitable for analytical and preparative workflows.
Medchemexpress LLC IFN-gamma Sheep Hi 20ug
IFN-gamma (interferon-gamma) is a type II interferon produced by T cells and NK cells which can significantly activate antibacterial antiviral and antitumor responses It acts through the JAK-STAT pathway and its receptor IFNGR1 to affect gene regulation IFN-gamma Protein Sheep (His) is the recombinant sheep-derived IFN-gamma protein expressed by E coli with N-6 His labeled tag
Medchemexpress LLC Fc gamma RIIB/CD32b 10ug | 10ug
Fc RIIB/CD32b proteins exhibit low affinity as complexes or receptors that aggregate the immunoglobulin Fc region ITIM phosphorylated by Fc RIIB/CD32b recruits inositol phosphatases SHIP1 and SHIP2 inhibits Ras activation down-regulates MAPK activity reduces PLC- function and results in PKC activation Inhibition of MAP kinase pathway and anti-apoptotic kinase Akt inhibit cell proliferation and survival Fc gamma RIIB/CD32b Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived Fc gamma RIIB/CD32b protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC IFN-gamma Rat 2ug
Recombinant rat interferon-gamma (IFN-γ) protein supplied lyophilized for research use. This pro-inflammatory cytokine exhibits immunomodulatory, antiproliferative, and antiviral activities and is intended for use in cell signaling, immunology assays, and functional studies. The product is provided with documentation on purity, formulation, and storage to support reproducible experimental results.
- Recombinant rat interferon-gamma protein suitable for in vitro assays.
- Pro-inflammatory and immunomodulatory activity for functional studies.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Lyophilized formulation for extended stability and convenient storage.
- Includes recommended reconstitution guidance to support experimental consistency.
- Stable when stored lyophilized at -20°C; freeze aliquots after reconstitution for long-term storage.