Oxazinanes
Apexbio Technology LLC Yohimbine Hydrochloride 65-19-0 10mM (in 1mL DMSO)
Yohimbine Hydrochloride (65-19-0) is a small-molecule antagonist targeting -2 adrenergic receptors It is designed to selectively bind to pre- and postsynaptic -2 adrenergic receptors thereby reducing receptor-mediated inhibition and increasing the synaptic release of norepinephrine and dopamine Yohimbine Hydrochloride exerts its biological activity primarily through antagonism of -2 adrenergic receptors Reported IC50 values for inhibition at -2 adrenergic receptor subtypes generally range between 40 90 nM depending on receptor subtype and assay conditions Based on these pharmacological properties Yohimbine Hydrochloride holds research potential in neuroscience particularly in studies investigating the neurobiological mechanisms underlying anxiety depression and addiction-related behaviors
Apexbio Technology LLC PRT062607 Hydrochloride 1370261-97-4 10mM (in 1mL DMSO)
PRT062607 Hydrochloride (CAS 1370261-97-4) is a selective inhibitor of spleen tyrosine kinase (SYK) a cytoplasmic kinase involved predominantly in hematopoietic signaling pathways notably within B cells It demonstrates potent inhibitory activity with an IC50 of approximately 1 nM and shows high selectivity for SYK over a range of other kinases Treatment of non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) B cell lines with PRT062607 Hydrochloride results in inhibition of SYK activation and induction of caspase-dependent apoptosis In murine xenograft models employing Ramos tumor cells systemic administration reduces tumor growth These features highlight PRT062607 Hydrochloride as a tool compound valuable for studying B cell malignancies and SYK-mediated signaling events
Apexbio Technology LLC LY 333531 hydrochloride 169939-93-9 1mg
LY 333531 hydrochloride (CAS 169939-93-9) is a biologically active orally available small molecule that selectively inhibits protein kinase C beta (PKC ) It demonstrates ATP-competitive inhibition with reported IC50 values of 4 7 nM for PKC I and 5 9 nM for PKC II indicating high specificity toward these isoforms Due to its targeted inhibition of PKC LY 333531 hydrochloride is extensively studied in the context of diabetic pathology and related complications
Selleck Chemical LLC Nebivolol hydrochloride (R-65824) S1549-10mM/1mL
Nebivolol HCl (R-65824) selectively inhibits 1-adrenoceptor with IC50 of 0 8 nM
TARGETMOL CHEMICALS INC S-Niguldipine hydrochloride
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (S)-(+)-Niguldipine hydrochloride is a selective alpha1A-AR antagonist used in the study of depression and epilepsy. Purity 98.06%
TARGETMOL CHEMICALS INC PDK4-IN-1 hydrochloride 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. PDK4-IN-1 hydrochloride, an anthraquinone derivative, is a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 value of 84 nM. Purity 99.54%
TARGETMOL CHEMICALS INC Normetanephrine hydrochloride
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Normetanephrine hydrochloride (DL-Normetanephrine hydrochloride) is a metabolite of Epinephrine. It is found together with Metanephrine in urine and in certain tissues. Purity 99.16%
TARGETMOL CHEMICALS INC Imazodan hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure. Purity 99.84%
TARGETMOL CHEMICALS INC Temiverine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine. Purity 99.43%
TARGETMOL CHEMICALS INC Besipirdine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibits biogenic amine uptake.Besipirdine hydrochloride reduces schedule-induced thirst and enhances cholinergic and adrenergic neurotransmission in the central nervous system in rats. Purity 98.4%
eMolecules 32816-99-2 | 4-PHENYLMORPHOLINE-2,3-DIONE | AstaTech | MFCD00152746 | 191.186 | C10H9NO3 | 95.000 | O=C1OCCN(C1=O)c1ccccc1 | 1g | 391060223
4-PHENYLMORPHOLINE-2,3-DIONE | AstaTech | 32816-99-2 | MFCD00152746 | 191.186 | C10H9NO3 | 95.000 | O=C1OCCN(C1=O)c1ccccc1 | 1g | 391060223
Selleck Chemical LLC Ligustrazine hydrochloride S3775-25mg
Ligustrazine hydrochloride (Tetramethylpyrazine Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation antioxidant antiplatelet and antiapoptosis activities
Selleck Chemical LLC Formoterol Hemifumarate S2020-1g
Formoterol Hemifumarate (Eformoterol CGP 25827A NSC 299587 YM 08316 Formoterol fumarate) is a potent selective and long-acting 2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD)
Selleck Chemical LLC MPTP hydrochloride S4732-200mg
MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism MPTP hydrochloride induces apoptosis MPTP hydrochloride can be used to induce animal models of Parkinson s disease
Selleck Chemical LLC Harmine hydrochloride S3817-10mM/1mL
Harmine (Telepathine) a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A with about 60-fold higher IC50 value for DYRK2 Harmine also inhibits monoamine oxidases (MAOs) PPAR and cdc-like kinases (CLKs) Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM