Oxazinanes
Medchemexpress LLC Pramipexole dihydrochloride | 104632-25-9 | 99.7% | 284.25 | 1 ML
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective dopamine D2-type receptor agonist
- BBB penetrant
- Useful for research into Parkinson's disease (PD) and restless legs syndrome (RLS)
- Cytoprotective properties
- Reduces infarction volume
- Improves neurological recovery
- Prevents ischemic cell death
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 25 MG
Cayman Chemical Dimebolin hydrochloride
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg
![eMolecules Pharmablock tert-butyl cis-1233a4577a-octahydropyrrolo[23-c]pyridine-6-carboxylate 5g 551295774 PBV0076 1286755-20-1 MFCD28396680 226.320 C12H22N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502695807.jpg-250.jpg)
eMolecules Pharmablock tert-butyl cis-1233a4577a-octahydropyrrolo[23-c]pyridine-6-carboxylate 5g 551295774 PBV0076 1286755-20-1 MFCD28396680 226.320 C12H22N2O2
Pharmablock tert-butyl cis-1233a4577a-octahydropyrrolo[23-c]pyridine-6-carboxylate 5g 551295774 PBV0076 1286755-20-1 MFCD28396680 226.320 C12H22N2O2
Medchemexpress LLC Bomedemstat dihydrochloride | 99.6% | 592.54 | 50 MG
Bomedemstat dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation to alter gene expression, showing anti-cancer activities by inhibiting cancer cell proliferation and inducing apoptosis.
- Orally active.
- Irreversible LSD1 inhibitor.
- Increases H3K4 and H3K9 methylation.
- Alters gene expression.
- Exhibits anti-cancer activities.
- Inhibits cancer cell proliferation.
- Induces apoptosis.
- Selectively inhibits proliferation and induces apoptosis of Jak2V617F cells.
- Enhances cell survival and induces apoptosis via BCL-XL and PUMA.
- Leads to cell cycle arrest.
- Normalizes or improves blood cell counts in animal models.
- Reduces spleen volumes in animal models.
- Restores normal splenic architecture.
- Reduces bone marrow fibrosis in animal models.
Selleck Chemical LLC Revaprazan Hydrochloride S5058-25mg
Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects Revaprazan Hydrochloride reversibly inhibits H( )/K( )-ATPase via binding to the K -binding site of the pump
Apexbio Technology LLC SB-505124 hydrochloride 356559-13-2 10mM (in 1mL DMSO)
SB-505124 hydrochloride (CAS 356559-13-2) is a potent selective inhibitor targeting transforming growth factor-beta (TGF ) receptors ALK4 and ALK5 SB-505124 functions by reversibly competing with ATP binding exhibiting IC50 values of 129 nM for ALK4 and 47 nM for ALK5 By blocking these receptor kinases the compound effectively inhibits downstream signaling events such as Smad2/3 phosphorylation and expression of TGF -regulated genes ( -SMA and CTGF) Research demonstrates its applicability in fibrotic disease models including glaucoma filtration surgery by preventing fibroblast activation and extending filtration bleb lifespan in vivo
TARGETMOL CHEMICALS INC NPS-2143 HYDROCHLORIDE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. purity: 99%
eMolecules ChemScene Ethyl (R)-morpholine-2-carboxylate hydrochloride 1g 726025218 CS-0468795 1820569-61-6 MFCD26792471 195.640 C7H14ClNO3
ChemScene Ethyl (R)-morpholine-2-carboxylate hydrochloride 1g 726025218 CS-0468795 1820569-61-6 MFCD26792471 195.640 C7H14ClNO3
eMolecules ChemScene N-Boc-NN-dimethylethylenediamine 10g 536839805 CS-M3426 112257-19-9 MFCD09953267 188.271 C9H20N2O2
ChemScene N-Boc-NN-dimethylethylenediamine 10g 536839805 CS-M3426 112257-19-9 MFCD09953267 188.271 C9H20N2O2
![eMolecules ChemScene 2-Chloro-3-fluoro-5-iodopyridin-4-amine 5g 837433987 CS-0167775 1801841-62-2 [null] 272.450 C5H3ClFIN2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694283.jpg-250.jpg)
eMolecules ChemScene 2-Chloro-3-fluoro-5-iodopyridin-4-amine 5g 837433987 CS-0167775 1801841-62-2 [null] 272.450 C5H3ClFIN2
ChemScene 2-Chloro-3-fluoro-5-iodopyridin-4-amine 5g 837433987 CS-0167775 1801841-62-2 [null] 272.450 C5H3ClFIN2
Medchemexpress LLC GPNA hydrochloride | 67953-08-6 | 99.6% | 303.70 | 1 ML
GPNA hydrochloride is identified as a substrate of the enzyme γ-glutamyltransferase (GGT) and a specific glutamine (Gln) transporter ASCT2 inhibitor. It also inhibits Na+-dependent carriers like the SNAT family (SNAT1/2/4/5) and Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells.
- Substrate of the enzyme γ-glutamyltransferase (GGT)
- Specific glutamine (Gln) transporter ASCT2 inhibitor
- Inhibits Na+-dependent carriers (SNAT family)
- Inhibits Na+-independent leucine transporters (LAT1/2)
- Reversibly induces apoptosis in A549 cells
Sigma Aldrich Fine Chemicals Biosciences TrizmaR hydrochloride reag50KG
Trizma(R) hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH SOLUTIONon.
