Oxazinanes
TARGETMOL CHEMICALS INC Temiverine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine. Purity 99.43%
Selleck Chemical LLC Colesevelam Hydrochloride
Colesevelam Hydrochloride is an orally administered non-absorbable polymeric bile-acid-binding agent with a higher affinity for glycocholic acid in vitro
eMolecules ChemScene N1-Methylbenzene-13-diamine 5g 632276135 CS-0019198 50617-73-7 MFCD11132708 122.171 C7H10N2
ChemScene N1-Methylbenzene-13-diamine 5g 632276135 CS-0019198 50617-73-7 MFCD11132708 122.171 C7H10N2
TARGETMOL CHEMICALS INC Syk Inhibitor II hydrochloride
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-beta-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines. Purity 98.17%
TARGETMOL CHEMICALS INC S-Niguldipine hydrochloride
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (S)-(+)-Niguldipine hydrochloride is a selective alpha1A-AR antagonist used in the study of depression and epilepsy. Purity 98.06%
Selleck Chemical LLC Vazegepant hydrochloride
Vazegepant hydrochloride (BHV-3500 Zavegepant) is a highly potent selective and structurally unique small molecule antagonist of CGRP receptor It can also be used for the acute treatment of migraine
Medchemexpress LLC Vacquinol-1 dihydrochloride (NSC13316 dihydrochloride) | 2309312-85-2 | 99.7% | 425.78 | 25 MG
Vacquinol-1 dihydrochloride (NSC13316) is a MKK4-specific activator that activates MAPK pathways. It specifically induces human glioblastoma cell (GC) death, attenuates tumor progression, and prolongs survival in a glioblastoma multiforme (GBM) mouse model. This compound also induces apoptosis in hepatocellular carcinoma (HCC) cells.
- MKK4-specific activator
- Activates MAPK pathways
- Induces glioblastoma cell death
- Attenuates tumor progression in glioblastoma multiforme mouse models
- Prolongs survival in glioblastoma multiforme mouse models
- Induces apoptosis in hepatocellular carcinoma cells
- Purity of 99.7%
- Appearance: white to off-white solid
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | 99.96% | C9H17Cl2N5O3 | 50 MG
Sapropterin dihydrochloride is an analytical standard used for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, helping to reduce blood phenylalanine concentrations. This compound is suitable for studying phenylketonuria (PKU). It is an analytical standard grade, commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Useful in the study of phenylketonuria (PKU)
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Sapropterin dihydrochloride (standard) | 69056-38-8 | 100.0% | C9H17Cl2N5O3 | 5 MG
Sapropterin dihydrochloride (Standard) is the analytical standard of Sapropterin (dihydrochloride), intended for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, reducing blood phenylalanine concentrations, and is used in the study of phenylketonuria (PKU). Additionally, it can aggravate experimental autoimmune encephalomyelitis (EAE).
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Used in the study of phenylketonuria (PKU)
- Can aggravate experimental autoimmune encephalomyelitis (EAE)
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | 99.79% | 239.23 | 100 MG
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer that can cross the blood-brain barrier. It is a reduced non-conjugated pteridine and the main metabolite of 4-amino-tetrahydro-L-biopterin, which undergoes photooxidation to form biopterin. This compound promotes the conversion of nitric oxide synthase to a superoxide-producing form, leading to increased oxidative stress in the renal outer medulla and inducing apoptosis.
- NOS uncoupling inducer
- Can cross the blood-brain barrier
- Promotes conversion of nitric oxide synthase to a superoxide-producing form
- Increases oxidative stress in the renal outer medulla
- Induces apoptosis
- Sensitive to inhibitory effect of SOD
- Used in research related to salt-sensitive hypertension and neurodegenerative diseases
eMolecules ChemScene tert-Butyl 3-(cyclopropylamino)-3-methylpiperidine-1-carboxylate 100mg 811576827 CS-0650079 1420898-14-1 MFCD24383571 254.374 C14H26N2O2
ChemScene tert-Butyl 3-(cyclopropylamino)-3-methylpiperidine-1-carboxylate 100mg 811576827 CS-0650079 1420898-14-1 MFCD24383571 254.374 C14H26N2O2
eMolecules Ambeed (R)-3-Methoxypyrrolidine 5g 589946567 A848949 120099-60-7 MFCD09953439 101.149 C5H11NO
Ambeed (R)-3-Methoxypyrrolidine 5g 589946567 A848949 120099-60-7 MFCD09953439 101.149 C5H11NO
eMolecules ChemScene 25-Dibromopyridin-3-amine 25g 572179909 CS-0052143 90902-84-4 MFCD09266224 251.909 C5H4Br2N2
ChemScene 25-Dibromopyridin-3-amine 25g 572179909 CS-0052143 90902-84-4 MFCD09266224 251.909 C5H4Br2N2
Selleck Chemical LLC Bobcat339 hydrochloride
Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 M and 73 M for TET1 and TET2 respectively Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe
Selleck Chemical LLC Nilotinib hydrochloride S5205-10mM/1mL
Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity