Oxazinanes
Medchemexpress LLC Iadademstat (dihydrochloride) | 1431303-72-8 | 99.98% | 1 ML
Product Overview
Iadademstat (ORY-1001) is a highly potent, orally active, and selective LSD1 (KDM1A) inhibitor that exhibits antileukemic activity. It is intended for research use, particularly in studies concerning relapsed or refractory acute myeloid leukemia.Features and Benefits
- Highly potent, orally active, and selective LSD1 (KDM1A) inhibitor.
- Exhibits antileukemic activity.
- Can be used for research on relapsed or refractory acute myeloid leukemia.
- Inhibits the proliferation of cancer cells (H1299 and A549), arrests the cell cycle at G1 phase, and induces apoptosis in vitro.
- Decreases glycolysis in H1299 and A549 cells by reducing HK2 protein levels in vitro.
- Demonstrates antitumor activity and increases survival rate in glioblastoma xenograft mouse models in vivo.
Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.9% | 50 MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It shows high selectivity for KDM1A and potent cellular activity in acute myeloid leukemia (AML) cell lines. This inhibitor induces the Cd11b differentiation marker and reduces AML tumor growth, enhancing survival in T-ALL models.
- Inhibits KDM1A by irreversible binding to the FAD cofactor.
- Highly selective for KDM1A over MAO enzymes and KDM1B.
- Potent cellular activity in differentiation and colony formation assays on MLL-translocated AML cell lines.
- Induces Cd11b differentiation marker in MLL-AF9 cells.
- Reduces AML tumor growth in mice and rat xenografts.
- Increases survival time in a disseminated model of T-ALL.
Medchemexpress LLC Iadademstat (dihydrochloride) | 1431303-72-8 | 100.0% | 100 MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It inactivates KDM1A by irreversibly binding to the flavin adenine nucleotide (FAD) cofactor. This compound shows high selectivity for KDM1A over MAO enzymes and KDM1B, and potent subnanomolar cellular activity against mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines. It reduces AML tumor growth in animal xenografts and prolongs survival in T-ALL models.
- Selective irreversible KDM1A/LSD1 inhibitor
- Inactivates KDM1A by binding to FAD cofactor
- High selectivity for KDM1A over MAO enzymes and KDM1B
- Potent subnanomolar cellular activity against MLL-translocated AML cell lines
- Reduces AML tumor growth in animal xenografts
- Prolongs survival in disseminated T-ALL models
Medchemexpress LLC CNDAC hydrochloride | 134665-72-8 | 98.0% | 288.69 | 1 ML
This compound is a metabolite and a nucleoside analog that has been shown to induce DNA damage and programmed cell death. It exhibits its effects by causing single-strand breaks in DNA which convert to double-strand breaks during cell replication. The compound has demonstrated inhibitory activity against various human cancer cell lines, as well as murine leukemia cells. In animal models, it has shown antitumor activity, increasing survival time and rate.
- Metabolite of an orally active agent.
- Nucleoside analog.
- Induces DNA damage.
- Induces apoptosis.
- Available as both solid and pre-made solution.
- High purity of over 98%.
Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.98% | 303.27 | 10 MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It inactivates KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. This compound exhibits high selectivity for KDM1A over MAO enzymes and KDM1B, with subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines.
- Selective irreversible KDM1A inhibitor
- Inactivates KDM1A by binding to FAD cofactor
- High selectivity for KDM1A over MAO enzymes and KDM1B
- Shows subnanomolar cellular activity in MLL-translocated AML cell lines
- Induces Cd11b differentiation marker in MLL-AF9 cells
- Reduces AML tumor growth in mice and rat xenografts
- Increases survival time in a disseminated model of T-ALL