Oxazinanes
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 1 ML
Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo.
- Orally available and selective estrogen receptor degrader (SERD).
- Inhibits growth of ER+ breast cancer cell lines in vitro and in vivo.
- Demonstrates antitumor activity in breast cancer xenograft models.
- Induces complete tumor growth inhibition in mice.
- Tumor growth inhibition is maintained for 4 weeks after withdrawal.
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 25 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 nM for ERα and 870 nM for ERβ. It can also inhibit the growth of ER+ breast cancer cell lines in vitro and in vivo. This compound is designed for high-speed applications in research settings.
- Inhibits ERα expression with an EC50 of 0.6 nM in MCF-7 cells.
- Decreases expression of progesterone receptor in MCF7 and T47D cell lines.
- Antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo.
- Induces complete tumor growth inhibition in mice.
- Maintains tumor growth inhibition for 4 weeks after withdrawal.
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 50 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) that can inhibit the growth of ER+ breast cancer cell lines in vitro and in vivo. It is effective against ERα and ERβ, making it suitable for research into hormone receptor-positive breast cancers.
- Orally available and selective estrogen receptor degrader (SERD)
- Inhibits the growth of ER+ breast cancer cell lines in vitro and in vivo
- Effective against ERα and ERβ targets
- Suitable for various research applications in breast cancer studies
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 5 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) that inhibits the growth of ER+ breast cancer cell lines both in vitro and in vivo. It has IC50s of 48 nM for ERα and 870 nM for ERβ. This product is for research use only and not sold to patients.
- Orally available and selective estrogen receptor degrader
- Inhibits the growth of ER+ breast cancer cell lines
- For research use only
- Appearance: white to off-white solid
- Shipped at room temperature
- Stored at 4°C, sealed, away from moisture
- In solvent, stored at -80°C for 6 months or -20°C for 1 month