Piperidines
eMolecules 144217-65-2 | Medchem Express | YYA-021 | 5mg | 446254912 | HY-100039 | MFCD00738763 | 317.433 | C18H27N3O2
ChemScene | Fmoc-S-3-amino-4-(3-bromophenyl)-butyric acid | 100mg | 711934379 | CS-0182728 | 1956435-50-9 | MFCD11617954 | 480.358 | C25H22BrNO4
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eMolecules 194093-42-0 | Medchem Express | Pumosetrag Hydrochloride | 5mg | 446270071 | HY-19650 | MFCD00939557 | 339.84 | C15H18ClN3O2S
Ambeed | Ethyl 3-amino-5-bromobenzofuran-2-carboxylate | 100mg | 628567676 | A524228 | 330555-71-0 | MFCD00454292 | 284.109 | C11H10BrNO3
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eMolecules 110816-78-9 | Medchem Express | KY-556 | 5mg | 415689827 | HY-U00148 | MFCD06809908 | 725.57 | C33H38Cl2N2O12
Ambeed | Amino(imino)methanesulfonic acid | 100mg | 525036008 | A131304 | 1184-90-3 | MFCD19203404 | 124.110 | CH4N2O3S
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eMolecules 1075236-89-3 | Medchem Express | Gepotidacin | 1mg | 446267800 | HY-16742 | MFCD27987926 | 448.527 | C24H28N6O3
Medchem Express | Stenoparib | 5mg | 446261196 | HY-12418 | 1140964-99-3 | MFCD28167842 | 317.352 | C18H15N5O
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Medchemexpress LLC Piperidin-2-one | 675-20-7 | 99.9% | 99.13 g/mol | C5H9NO | 10 G
2-Piperidone (piperidin-2-one; δ-valerolactam) is an endogenous metabolite and a biomarker for CYP2E1 activity. It is supplied as a high-purity research standard for use in analytical, metabolic, and pharmacological studies. CAS number 675-20-7; molecular formula C5H9NO; molecular weight 99.13 g/mol; purity 99.89%.
- high-purity research-grade material suitable for analytical assays and reference standards.
- soluble in DMSO and water at high concentrations with ultrasonic aid.
- provided in multiple pack sizes to support small-scale and bulk experiments.
- storage recommendations available for long-term stability in solid and solvent forms.
Accela Chembio Inc N-boc-4-nortropinone | 25g | 185099-67-6 | MFCD00673779 | 98% | Shelf Life: 1980 Days | Regular
N-boc-4-nortropinone | 25g | 185099-67-6 | MFCD00673779 | 98% | Shelf Life: 1980 Days | Regular
Medchemexpress LLC TD-0212 TFA 10mg | 1073549-11-7 | 10 MG
TD-0212 TFA is a research-grade small molecule supplied as the trifluoroacetate (TFA) salt that acts as an orally active dual angiotensin II type 1 (AT1) receptor antagonist and neprilysin (NEP) inhibitor. It is provided as a white to off-white solid for laboratory research use only.
- Dual AT1 antagonist and NEP inhibitor with reported pKi 8.9 and pIC50 9.2.
- High purity (98.44%) suitable for biological research.
- Molecular formula C30H35F4N3O6S; molecular weight 641.67.
- Soluble in DMSO (125 mg/mL) and compatible with in vivo co-solvent preparation protocols.
- Stable when stored sealed at -20°C; in solution store at -80°C for long term.
Enzo Life Sciences dBET1 (100mg). CAS: 1799711-21-9
dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4. Purity: ≥99%. Long Term Storage: -20°C.
Selleck Chemical LLC BSJ-4-116-5mg
BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.
Medchemexpress LLC BSJ-4-116 | 2519823-34-6 | 99.9% | 837.38 | 50 MG
BSJ-4-116 is a PROTAC (proteolysis-targeting chimera) designed to selectively degrade CDK12 (Cyclin-Dependent Kinase 12) with high potency, evidenced by an IC50 of 6 nM. It achieves its effect by linking ligands for Cereblon and CDK, leading to the downregulation of DNA damage response (DDR) genes through premature transcriptional termination and increased poly(adenylation). This compound exhibits significant antiproliferative capabilities, both as a standalone agent and in combination with the PARP inhibitor Olaparib. It has been shown to decrease CDK12 protein levels regardless of the cell line's mutational status and can overcome resistance due to specific CDK12 mutations.
- Highly potent and selective CDK12 degrader
- Downregulates DNA damage response genes
- Exhibits antiproliferative effects
- Can overcome resistance from specific CDK12 mutations
Aobchem 3-Formylphenylboronic acid pinacol ester | ≥97% | CAS 380151-86-0 | C13H17BO3 | 25g
3-Formylphenylboronic acid pinacol ester | ≥97% | CAS 380151-86-0 | C13H17BO3 | 25g
eMolecules 1422252-46-7 | Medchem Express | BI-9627 (hydrochloride) | 5mg | 624169625 | HY-18071A | MFCD30182310 | 392.81 | C16H20ClF3N4O2
ChemScene | 5-Bromo-1H-indazol-4-amine | 100mg | 632324794 | CS-0160659 | 1891120-48-1 | MFCD30721204 | 212.050 | C7H6BrN3
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Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 50 MG
AMG-548 dihydrochloride is an orally active and selective inhibitor of p38α (Ki=0.5 nM), showing slight selectivity over p38β (Ki=36 nM) and more than 1000-fold selectivity against p38γ and p38δ. It is also highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM). Additionally, this compound inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor with high potency.
- Potent inhibition of whole blood LPS-stimulated TNFα and IL1β.
- Inhibits Wnt signaling through direct targeting of Casein kinase 1 isoforms δ and ε.
- Good oral bioavailability in vivo.
![Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235232.png-250.jpg)
Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG
ML-099 (CID-888706) is a small-molecule pan activator of Ras-related GTPases provided for research use. It enhances GTPase activity by increasing affinity for guanine nucleotides and activates multiple small GTPases relevant to cytoskeletal dynamics and signaling pathways. The compound is supplied as a solid in several pack sizes and as a DMSO solution for cell-based and biochemical assays.