Piperidines
eMolecules 3466-80-6 | Ambeed | 2-Phenylpiperidine | 1g | 491166965 | A118058 | MFCD00270125 | 161.248 | C11H15N
ChemScene | 4-(2-Bromophenyl)oxazole | 100mg | 712833151 | CS-0366275 | 850349-06-3 | MFCD08706070 | 224.057 | C9H6BrNO
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eMolecules Building Block Tool
Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 50 MG
AMG-548 dihydrochloride is an orally active and selective inhibitor of p38α (Ki=0.5 nM), showing slight selectivity over p38β (Ki=36 nM) and more than 1000-fold selectivity against p38γ and p38δ. It is also highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM). Additionally, this compound inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor with high potency.
- Potent inhibition of whole blood LPS-stimulated TNFα and IL1β.
- Inhibits Wnt signaling through direct targeting of Casein kinase 1 isoforms δ and ε.
- Good oral bioavailability in vivo.
![Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235232.png-250.jpg)
Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG
ML-099 (CID-888706) is a small-molecule pan activator of Ras-related GTPases provided for research use. It enhances GTPase activity by increasing affinity for guanine nucleotides and activates multiple small GTPases relevant to cytoskeletal dynamics and signaling pathways. The compound is supplied as a solid in several pack sizes and as a DMSO solution for cell-based and biochemical assays.
![Medchemexpress LLC 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-indol-4-yl)-4-(4-morpholinyl)-thieno-pyrimidine | 955977-50-1 | 99.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230705.png-250.jpg)
Medchemexpress LLC 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-indol-4-yl)-4-(4-morpholinyl)-thieno-pyrimidine | 955977-50-1 | 99.0% | 50 MG
PI-3065 is a selective small-molecule inhibitor of PI3K p110δ used for research applications. It potently inhibits p110δ (IC50 5 nM; Ki 1.5 nM) and shows substantially lower activity against other PI3K isoforms, and is supplied as a solid for in vitro and in vivo studies.
- Potent p110δ inhibition (IC50 5 nM; Ki 1.5 nM).
- Reduced activity against p110α (IC50 910 nM), p110β (IC50 600 nM), p110γ (>10,000 nM).
- Purity approximately 98.97%.
- Chemical formula C27H31FN6OS; molecular weight 506.64 g/mol.
- Appearance: white to off-white solid.
- Soluble in DMSO (25 mg/mL) and formulatable for in vivo dosing.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years).
- Available in small-mass pack sizes (for example 50 mg).
eMolecules 340-07-8 | 1-Trifluoroacetyl piperidine | Oakwood Chemical | MFCD00466213 | 181.158 | C7H10F3NO | 99.000 | FC(F)(F)C(=O)N1CCCCC1 | 25g | 537704748
1-Trifluoroacetyl piperidine | Oakwood Chemical | 340-07-8 | MFCD00466213 | 181.158 | C7H10F3NO | 99.000 | FC(F)(F)C(=O)N1CCCCC1 | 25g | 537704748
Apexbio Technology LLC Ropivacaine hydrochloride monohydrate 132112-35-7 50mg
Ropivacaine hydrochloride monohydrate (CAS 132112-35-7) is a long-acting amide local anesthetic widely studied for its pharmacological and electrophysiological properties It inhibits ATP-sensitive potassium (KATP) channels particularly SUR2A/Kir6 2 as demonstrated in COS-7 cell models where inhibition is concentration-dependent and reversible Reported IC50 values for SUR2A/Kir6 2 SUR2B/Kir6 1 SUR2B/Kir6 2 and Kir6 2 C36 channels are 249 11 2235 115 2442 132 and 2375 179 M respectively Additionally ropivacaine hydrochloride monohydrate suppresses sarcolemmal KATP channels in cardiovascular tissues via stereoselective and tissue-specific mechanisms supporting its utility in studies of ion channel pharmacology and cardiovascular safety profiles
Apexbio Technology LLC Ropivacaine HCl 98717-15-8 10mM (in 1mL H2O)
Ropivacaine HCl (CAS 98717-15-8) is a local anesthetic agent commonly employed in biomedical research to examine neuronal function and signal transmission Mechanistically ropivacaine hydrochloride acts by reversibly blocking the influx of sodium ions across neuronal membranes thereby inhibiting the conduction of nerve impulses Due to this mode of action it serves as a useful pharmacological tool in studies designed to elucidate pain signaling pathways sodium channel behavior and peripheral nerve function
Medchemexpress LLC Ropivacaine impurity 500mg
Ropivacaine impurity 1 hydrochloride is an impurity of Ropivacaine (HY-B0563)
American Radiolabeled Chemicals Inc DONEPEZIL HCL 10ME
Donepezil hydrochloride 10mg as solid, M.W. 415.99, Solvent: Solid, CAS# 120011-70-3
