Piperidines

Ambeed Dibenzo b d thiophene 5oxide

Dibenzo[b,d]thiophene 5-oxide, 1013-23-6, 95%

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eMolecules​ Roxatidine acetate hydrochloride | 93793-83-0 | MFCD00941429 | 1g

Combi-Blocks, Inc. | Roxatidine acetate hydrochloride | 1g | 603153594 | QN-4068 | 95.000 | 93793-83-0 | MFCD00941429 | 384.900 | C19H29ClN2O4

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Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 50 MG

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JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It induces apoptosis, increases the expression of cleaved PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).

• Potent and selective IRAK1 PROTAC degrader
• IC50s of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP
• Induces apoptosis and increases cleaved PARP expression
• Decreases expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)

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Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 25 MG

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JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It has IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases the expression of cleavaged PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).

• Potent and selective IRAK1 PROTAC degrader
• IRAK1 IC50: 72 nM
• IRAK4 IC50: 443 nM
• VHL FP IC50: 1071 nM
• Induces apoptosis and increases cleaved PARP expression
• Decreases IRAK1, p-IKBα, and pSTAT3(Tyr705) expression
• Degrades IRAK1 protein with a DC50 value of 3 nM in a dose-dependent manner
• Demonstrated decreased IRAK1 expression in HEK293T cells (1.5-10000 nM)

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Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 50 MG

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pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase, functioning as a SOCS1/3 antagonist. This peptide blocks SOCS1-mediated negative regulation of immune function and enhances the biological activity of cytokines such as IFNγ and IL6. It has been shown to inhibit the replication of a broad range of viruses and offers dose-dependent protective efficacy against lethal viral infections, making it suitable for studying immune regulation and infection.

• Functions as a SOCS1/3 antagonist
• Blocks SOCS1-mediated negative regulation of immune function
• Enhances biological activity of cytokines like IFNγ and IL6
• Inhibits replication of a broad range of viruses
• Offers dose-dependent protective efficacy against lethal viral infections

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Medchemexpress LLC Roxatidine | 78273-80-0 | 98.25% | 306.40 | 50 MG

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Roxatidine is an active metabolite of Roxatidine acetate hydrochloride and an orally active histamine H2-receptor antagonist. It is an anti-ulcer agent that suppresses histamine release, inhibits proton secretion, and inhibits the production of VEGF-1. This agent also demonstrates anti-allergic inflammatory effects and is promising for research into gastric and duodenal ulcers.

• Orally active histamine H2-receptor antagonist
• Suppresses histamine release and inhibits proton secretion
• Inhibits production of VEGF-1
• Exhibits anti-allergic inflammatory effects
• Potential for research into gastric and duodenal ulcers
• Suppresses pro-inflammatory cytokine production and signaling pathways (in vitro)
• Inhibits inflammatory mediators such as PGE2, NO, and histamine (in vitro)
• Ameliorates allergic hypersensitivity and inflammation in anaphylactic animal models (in vivo)

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Medchemexpress LLC Roxatidine | 78273-80-0 | 98.25% | 306.41 | 100 MG

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Roxatidine is an active metabolite of Roxatidine acetate hydrochloride and an orally active histamine H2-receptor antagonist. As an anti-ulcer agent, it suppresses histamine release, inhibiting proton secretion, and inhibits the production of VEGF-1, which is a marker of inflammation and angiogenesis. It also has an anti-allergic inflammatory effect and is being researched for gastric and duodenal ulcers.

• Orally active histamine H2-receptor antagonist
• Suppresses histamine release (inhibiting proton secretion)
• Inhibits the production of VEGF-1
• Exhibits anti-allergic inflammatory effects
• Researched for gastric and duodenal ulcers

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Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 10 MG

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pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 10 MG

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Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.89% | 1716.82 | 25 MG

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pJAK2(1001-1013) | 1259928-08-9 | 99.89% | 1716.82 | 25 MG

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eMolecules​ 1-Benzyl-3-Boc-amino-piperidine-4-carboxylic acid ethyl ester | 2407051-38-9 | | 1g

J & W PharmLab LLC | 1-Benzyl-3-Boc-amino-piperidine-4-carboxylic acid ethyl ester | 1g | 499972445 | 60R1463 | 96.000 | 2407051-38-9 | | 362.470 | C20H30N2O4

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eMolecules​ Medchem Express / GSK2879552 (dihydrochloride) / 5mg / 632896568 / HY-18632A / / 1902123-72-1 / MFCD30481342 / 437.410 / C23H30Cl2N2O2

Medchem Express / GSK2879552 (dihydrochloride) / 5mg / 632896568 / HY-18632A / / 1902123-72-1 / MFCD30481342 / 437.410 / C23H30Cl2N2O2

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eMolecules​ 4-Benzylpiperidine | 31252-42-3 | MFCD00006006 | 25g

Chem-Impex | 4-Benzylpiperidine | 25g | 272387228 | 23231 | | 31252-42-3 | MFCD00006006 | 175.275 | C12H17N

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Sigma Aldrich Fine Chemicals Biosciences Donepezil hydrochloride >=98% (HPLC) | 120011-70-3 | MFCD00881312 | 50MG

Donepezil hydrochloride >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 415.95 | 120011-70-3 | MFCD00881312 | 50MG

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eMolecules​ benzyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | 84243-24-3 | MFCD09758966 | 1g

Pharmablock | benzyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | 1g | 551182164 | PBZS2205 | | 84243-24-3 | MFCD09758966 | 304.346 | C16H20N2O4

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Accela Chembio Inc 3-(1-piperidylmethyl)aniline | 5g | 93138-55-7 | MFCD04114502 | 95+% | Shelf Life: 1080 Days | Light Sensitive/nitrogen Or Argon/+4

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3-(1-piperidylmethyl)aniline | 5g | 93138-55-7 | MFCD04114502 | 95+% | Shelf Life: 1080 Days | Light Sensitive/nitrogen Or Argon/+4

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