Piperidines
Medchemexpress LLC 1-Boc-3-piperidone | 98977-36-7 | MFCD01631193 | >98.5% | 199.25 | 25 G
1-Boc-3-piperidone is a Boc-protected piperidone derivative and an important intermediate in organic synthesis. It can be used to study compounds related to inflammatory skin diseases (such as atopic dermatitis), lymphoma, and other diseases.
- Boc-protected piperidone derivative.
- Important intermediate in organic synthesis.
- Can be used to study compounds related to inflammatory skin diseases (e.g., atopic dermatitis).
- Applicable in research concerning lymphoma and other diseases.
Medchemexpress LLC (-)-p-Bromotetramisole (oxalate) | 62284-79-1 | 99.8% | 373.22 | 100 MG
(-)-p-Bromotetramisole oxalate is an alkaline phosphatase inhibitor that can be used in research related to erythroleukemia. This compound is applicable to research related to erythroleukemia. In Vitro, it potently inhibits terminal cell division-associated MEL DS-19 cell differentiation induced by 0.7% DMSO or 1.2 mM HMBA, reducing B+ cell levels. It also potently inhibits purified human liver, bone, spleen, and kidney alkaline phosphatase isoenzymes while minimally inhibiting purified human intestinal and placental alkaline phosphatase isoenzymes.
- Alkaline phosphatase inhibitor
- Applicable to research related to erythroleukemia
- Potently inhibits terminal cell division-associated MEL DS-19 cell differentiation
- Potently inhibits purified human liver, bone, spleen, and kidney alkaline phosphatase isoenzymes
- Minimally inhibits purified human intestinal and placental alkaline phosphatase isoenzymes
Medchemexpress LLC 1-Boc-2-piperidone | 85908-96-9 | >=98.0% | 199.25 | 10 G
1-Boc-2-piperidone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It appears as a solid, ranging from white to light brown.
- Molecular weight of 199.25
- Purity of 98.0%
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Solubility in DMSO is 200 mg/mL
eMolecules 2204226-02-6 | Medchem Express | Thalidomide-O-amido-PEG-C2-NH2 (hydrochloride) | 25mg | 600899865 | HY-122694A | 454.86 | C19H23ClN4O7
ChemScene | 2-(Pyridin-4-yl)cyclopropane-1-carboxylic acid | 250mg | 768996471 | CS-0465634 | 484654-49-1 | MFCD11934489 | 163.176 | C9H9NO2
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eMolecules 1370032-19-1 | Medchem Express | CA-5f | 5mg | 448039055 | HY-112698 | 388.467 | C24H24N2O3
Ambeed | Dimethyl pimelate | 100g | 491641177 | A210172 | 1732-08-7 | MFCD00008470 | 188.223 | C9H16O4
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Medchemexpress LLC HY-16954 50mg , ARV-825 CAS:1818885-28-7 Purity:98%
Medchemexpress, HY-16954 50mg ARV-825 CAS:1818885-28-7 Formula:C46H47ClN8O9S Kd: 90 nM (Bromodomain 1 of BRD4), 28 nM (Bromodomain 2 of BRD4) Purity:98% ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 shows affinity to BD1 and BD2 of BRD4 with K d s of 90 and 28 nM, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Biotium Fibronectin(2755-8), CF647 conjugate, 0.1mg/mL
Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblasts phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for det
Medchemexpress LLC Lenalidomide-acetylene-C5-COOH | 2429878-72-6 | 99.3% | 100 MG
Lenalidomide-acetylene-C5-COOH is a Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTAC. This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Lenalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker to form PROTAC
- Functions as a click chemistry reagent
- Contains an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 hydrochloride | 2245697-86-1 | MFCD31656719 | 98.1% | 438.86 g/mol | C19H23ClN4O6 | 100 MG
Thalidomide-O-amido-C4-NH2 hydrochloride is an E3 ligase (cereblon) ligand-linker intermediate supplied as the hydrochloride salt for research use. It is a white to off-white solid with documented molecular properties and high purity, intended for use in the synthesis of PROTACs and related heterobifunctional degraders.
- High purity suitable for synthetic applications.
- Hydrochloride salt form for improved handling and stability.
- Solid, white to off-white appearance for easy identification.
- Useful as a cereblon E3 ligase ligand-linker intermediate.
- Available in small research pack sizes for laboratory use.
- Documented molecular weight and formula for analytical reference.
Medchemexpress LLC dBET1 | 1799711-21-9 | MFCD31544503 | 99.0% | 785.27 | C38H37ClN8O7S | 50 MG
dBET1 is a PROTAC research compound that induces targeted degradation of BRD4 by recruiting the Cereblon E3 ubiquitin ligase. It is used in studies of BET bromodomain biology and targeted protein degradation in preclinical research.
- Induces Cereblon-mediated BRD4 degradation (EC50 ~430 nM).
- Designed as a bifunctional molecule linking a bromodomain ligand to a Cereblon ligand.
- High purity suitable for biochemical and cellular assays (≈99%).
- Available as a white to light yellow powder for easy handling.
- Stable when stored as a powder at -20°C for up to 3 years.
- Packaged in small research quantities for assay development (50 mg available).
Biotium Fibronectin(2755-8), CF594 conjugate, 0.1mg/mL
Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblasts phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for det
Medchemexpress LLC HY-111594 5mg Medchemexpress, Homo-PROTAC cereblon degrader 1 CAS:2244520-98-5 Purity:>98%
Medchemexpress, HY-111594 5mg Homo-PROTAC cereblon degrader 1 CAS:2244520-98-5 Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3 [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 2331259-45-9 | Medchem Express | Pomalidomide-amino-PEG4-NH2 (hydrochloride) | 25mg | 705860861 | HY-138859A | 542.97 | C23H31ClN4O9
Ambeed | tert-Butyl 2-carbamoylpyrrolidine-1-carboxylate | 1g | 506389982 | A275240 | 54503-10-5 | MFCD02183583 | 214.265 | C10H18N2O3
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TENOVA PHARMACEUTICALS INC POMALIDOMIDE-C5-AMINE HCL 50MG
POMALIDOMIDE-C5-AMINE HCL | 2375194-03-7 | MFCD31729299 | 50mg
Medchemexpress LLC AS-99 TFA | 99.2% | C29H31F6N5O5S2 | 50 MG
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces leukemia burden in vivo. The compound exhibits over 100-fold selectivity towards ASH1L, showing no significant inhibition on a panel of 20 other histone methyltransferases at 50 μM.
- Potent and selective ASH1L histone methyltransferase inhibitor
- Blocks cell proliferation and induces apoptosis
- Downregulates MLL fusion target genes
- Reduces leukemia burden in vivo
- Exhibits over 100-fold selectivity towards ASH1L
- Favorable exposure in plasma with a half-life of approximately 5-6 hours