Pyrans
4-(Dicyanomethylene)-2,6-dimethyl-4H-pyran 98.0+%, TCI America™
CAS: 28286-88-6 Molecular Formula: C10H8N2O Molecular Weight (g/mol): 172.19 MDL Number: MFCD00181519 InChI Key: XYBUCJYJVULPHW-UHFFFAOYSA-N Synonym: 2-(2,6-Dimethyl-4H-pyran-4-ylidene)propanedinitrile PubChem CID: 119915 IUPAC Name: 2-(2,6-dimethyl-4H-pyran-4-ylidene)propanedinitrile SMILES: CC1=CC(C=C(C)O1)=C(C#N)C#N
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 100 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s, and it also reduces ATF-5 protein. This compound is known to decrease cell proliferation and inhibit stress granule (SG) formation. It is intended for research use only.
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres.
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures.
- Hinders stress granule (SG) formation in U2OS cells.
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ.
- Increases the number of OLIG2-expressing cells in the corpus callosum in C57BL/6 mice.
- Affects the differentiation of neural stem and progenitor cells in different brain regions.
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 50 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s. It reduces ATF-5 protein, inhibits cell proliferation, and hinders stress granule (SG) formation. It is intended for research use only.
- G-quadruplex ligand
- Highly molecular specificity to RNA on DNA G4s
- Reduces ATF-5 protein
- Reduces cell proliferation
- Hinders stress granule (SG) formation
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres in vitro
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures in vitro
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice in vivo
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 1 ML
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand with high molecular specificity to RNA on DNA G4s. It reduces ATF-5 protein, inhibits cell proliferation, and hinders stress granule (SG) formation.
- Reduces the size of adult SVZ-derived neurospheres and the number of cells within them (1-25 μM; 3 days).
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures.
- Hindres stress granule (SG) formation in U2OS cells (10 μM; 24 hours).
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ of mice (10 mg/kg; i.p.; every 12 hours; 3 injections).
- Increases the number of OLIG2-expressing cells in the corpus callosum in mice.
- Affects the differentiation of neural stem and progenitor cells in different brain regions.
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 | 25 MG
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. It exhibits high molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Additionally, it reduces cell proliferation and hinders stress granule (SG) formation.
- G-quadruplex ligand
- High molecular specificity to RNA on DNA G4s
- Reduces ATF-5 protein
- Reduces cell proliferation
- Hinders stress granule (SG) formation
- Reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres
- Blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures
- Significantly reduces the number of PCNA-expressing cells in the adult SVZ in mice
- Increases the number of OLIG2-expressing cells in the corpus callosum in mice
Medchemexpress LLC Carboxy pyridostatin trifluoroacetate salt | 2444713-88-4 | 99.5% | 820.73 g/mol | C37H35F3N10O9 | 5 MG
Carboxy pyridostatin (trifluoroacetate salt) is a research-grade G-quadruplex ligand supplied as a solid salt for in vitro and in vivo studies. It selectively recognizes RNA on DNA G-quadruplex structures, reduces ATF-5 protein levels, inhibits cell proliferation, and impairs stress granule formation.
- Cas number: 2444713-88-4.
- Molecular formula: C37H35F3N10O9.
- Molecular weight: 820.73 g/mol.
- Purity: 99.5%.
- Pack sizes include 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
- Soluble in DMSO at 50 mg/mL with ultrasonic warming to 60°C.
- In vivo formulations achievable at ≥2.5 mg/mL in common vehicle mixtures.
- Storage: solid sealed away from moisture, recommended -20°C; in solution -80°C (6 months), -20°C (1 month).