Pyrazines
TARGETMOL CHEMICALS INC G36 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17(beta)-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM respectively). G36 has no detectable binding activity to either ER(alpha) or ER(beta). G36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF. G-36 can be used in combination with GPER-selective agonists like G-1 to distinguish the roles of GPER from those of ER(alpha) and ER(beta) in complex biological systems. purity: 99%
TARGETMOL CHEMICALS INC LOSARTAN CARBOXYLIC ACID 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis 0.57 nM rat; 0.67 nM human) producing a depressor response and vasodilatation. Losartan Carboxylic Acid a metabolite of losartan is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. purity: 99%
eMolecules 1161415-28-6 | NOTA-bis(t-Bu ester) | Combi-Blocks, Inc.415.531 | C20H37N3O6 | 95.000 | CC(C)(C)OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)OC(C)(C)C)CC1 | 1g | 797027356
NOTA-bis(t-Bu ester) | Combi-Blocks, Inc. | 1161415-28-6415.531 | C20H37N3O6 | 95.000 | CC(C)(C)OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)OC(C)(C)C)CC1 | 1g | 797027356
eMolecules 69105-00-6 | Trifluoromethoxy-acetic acid | J&W PharmLab LLC | MFCD11858185 | 144.049 | C3H3F3O3 | 96.000 | OC(=O)COC(F)(F)F | 5g | 642184062
Trifluoromethoxy-acetic acid | J&W PharmLab LLC | 69105-00-6 | MFCD11858185 | 144.049 | C3H3F3O3 | 96.000 | OC(=O)COC(F)(F)F | 5g | 642184062
eMolecules 110637-40-6 | Alloc-gly-oh dcha | Combi-Blocks, Inc. | MFCD08272340 | 340.464 | C18H32N2O4 | 98.000 | OC(=O)CNC(=O)OCC=C.C1CCC(CC1)NC1CCCCC1 | 5g | 761034750
Alloc-gly-oh dcha | Combi-Blocks, Inc. | 110637-40-6 | MFCD08272340 | 340.464 | C18H32N2O4 | 98.000 | OC(=O)CNC(=O)OCC=C.C1CCC(CC1)NC1CCCCC1 | 5g | 761034750
TARGETMOL CHEMICALS INC SU5408 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SU5408 (VEGFR2 Kinase Inhibitor I) is a potent cell-permeable inhibitor of the VEGFR2 kinase. purity: 98%
Apexbio Technology LLC 5-hydroxypyrazine-2-carboxylic acid 34604-60-9 1g
5-Hydroxypyrazine-2-carboxylic acid (CAS 34604-60-9) is a metabolite generated during the hepatic metabolism of the anti-tuberculosis drug pyrazinamide It is studied for its involvement in elucidating bacterial resistance mechanisms and drug metabolism pathways associated with Mycobacterium tuberculosis In vitro assays commonly utilize 5-Hydroxypyrazine-2-carboxylic acid to examine biological activity against mycobacterial enzymes related to tuberculosis pathogenesis and resistance development In enzyme inhibition studies this metabolite is employed to determine inhibition potencies characterized by IC50 measurements Based on these properties 5-Hydroxypyrazine-2-carboxylic acid holds research potential in drug discovery and resistance research for tuberculosis
TARGETMOL CHEMICALS INC SRT 1720 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SRT 1720 is a selective activator of human SIRT1 (EC1.5 0.16 uM) and is >230-fold less potent for SIRT2 and SIRT3. purity: 99%
TARGETMOL CHEMICALS INC LY3372689 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease. purity: 99%
TARGETMOL CHEMICALS INC SUDOTERB FREE BASE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Sudoterb free base (Sudoterb) also known as LL3858 is an anti-tubercular drug candidate. purity: 98%
TARGETMOL CHEMICALS INC IU1 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. IU1(IC50=4.7 u M) a reversible specific human USP14 proteasome inhibitor can penetrate the cell. purity: 99%
TARGETMOL CHEMICALS INC LY404039 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). purity: 99%
TARGETMOL CHEMICALS INC ASAPIPRANT 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor. purity: 99%
TARGETMOL CHEMICALS INC 20S-GINSENOSIDE RG3 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities. purity: 99%