Pyridines and derivatives
Medchemexpress LLC L-Phenylmercapturic acid-d5 | 1331906-27-4 | 99.1% | C11H8D5NO3S | 1 MG
L-Phenylmercapturic acid-d5 is a deuterium-labeled form of L-Phenylmercapturic acid. It is commonly used as a biomarker to assess exposure to aniline compounds, such as aniline and xylene. This compound can also serve as a tracer and an internal standard for quantitative analysis using various techniques.
- Biomarker for aniline compound exposure
- Tracer in drug development
- Internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration influences pharmacokinetic and metabolic profiles
Medchemexpress LLC Dexketoprofen (trometamol) | 156604-79-4 | 99.7% | 100 MG
Dexketoprofen trometamol is an orally active non-selective COX inhibitor. It has pain-relieving, anti-inflammatory, and anti-cancer effects.
- Pain-relieving effect.
- Anti-inflammatory effect.
- Anti-cancer effect.
- Significantly inhibits the viability of HeLa, HT-29, and MCF-7 cells.
- Effectively prevents hyperalgesia in a postoperative pain mouse model and inhibits microglial activation.
- Significantly reduces inflammation and oxidative stress in a xylene-induced ear edema rat model.
Medchemexpress LLC Dexketoprofen (trometamol) | 156604-79-4 | >98.0% | 25 MG
Dexketoprofen (trometamol) is an orally active non-selective COX inhibitor. It is commonly used as an analytical standard for research applications, exhibiting pain-relieving, anti-inflammatory, and anti-cancer effects.
- Acts as a non-selective COX inhibitor.
- Provides pain-relieving effects.
- Demonstrates anti-inflammatory properties.
- Exhibits anti-cancer activity by inhibiting viability of HeLa, HT-29, and MCF-7 cells.
- Used as an analytical standard in qualitative, quantitative, and methodological research experiments like HPLC, GC, and MS.
- Prevents hyperalgesia and inhibits microglial activation in postoperative pain mouse models.
- Reduces inflammation and oxidative stress in xylene-induced ear edema rat models.
Medchemexpress LLC Withangulatin A | 120824-03-5 | 526.62 | 5 MG
Withangulatin A is an inhibitor for COX-2 that demonstrates antitumor, anti-inflammatory, and trypanocidal activities. It inhibits MAPK, NF-κB, Akt/mTOR/p70S6K pathway, and various cellular processes in vitro and in vivo.
- Inhibits proliferation of mouse T lymphocytes with an EC50 of 2.89 μM
- Reduces LPS-induced secretion of IL-2, IFN-γ, and IL-6
- Suppresses expression of COX-2 and PGE2 in mouse T lymphocytes
- Arrests cell cycle at S phase and induces apoptosis in LX-2 cells
- Inhibits TGF-β-stimulated collagen I gene expression and phosphorylation of Smad2/3
- Binds to peroxiredoxin 6 (PRDX6) and inhibits GPx and iPLA2 activities
- Promotes generation of ROS
- Exhibits anti-inflammatory activity in mouse xylene-induced ear swelling models
- Shows antitumor effect in mouse H1975 xenograft models