Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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2,206 – 2,220 of 4,547 results

2,206

eMolecules PI-103 | 371935-74-9 | MFCD11983145 | 0.1g

AstaTech | PI-103 | 0.1g | 282977604 | 22944 | 95.000 | 371935-74-9 | MFCD11983145 | 348.362 | C19H16N4O3

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2,207

Medchemexpress LLC Pyrimidin-4-yl-methanol | 33581-98-5 | MFCD03789625 | ≥97.0% | 110.11 g/mol | C5H6N2O | 250 MG

Pyrimidin-4-yl-methanol (CAS 33581-98-5) is a small-molecule synthetic intermediate used in pharmaceutical and agrochemical synthesis and related chemical research. It is characterized by formula C5H6N2O and a molecular weight of 110.11 g/mol, and is supplied with quality documentation for research applications.

Synthetic intermediate for pharmaceutical synthesis.
High purity (≥97.0%) suitable for research and development.
Compact molecular weight of 110.11 g/mol with formula C5H6N2O.
Available in multiple pack sizes from 100 mg to 50 g.
Certificate of analysis and safety data sheet provided for verification.

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2,208

Selleck Chemical LLC Dorsomorphin 2HCl

Dorsomorphin 2HCl is a potent reversible selective AMPK inhibitor with Ki of 109 nM in cell-free assays exhibiting no significant inhibition of several structurally related kinases including ZAPK SYK PKC PKA and JAK3 Also inhibits type BMP receptor activity Dorsomorphin induces autophagy in cancer cell line

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2,209

Medchemexpress LLC N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide | 659730-32-2 | MFCD14584859 | 99.2% | 430.4 g·mol⁻¹ | C20H13F3N4O2S | 100 MG

AMG 517 is a small-molecule antagonist of the TRPV1 (vanilloid) ion channel used to probe TRPV1-mediated signaling and pharmacology. It exhibits sub-nanomolar inhibitory potency and is supplied as a research-grade chemical with batch-specific quality documentation.

Potent TRPV1 antagonist with reported IC50 in the sub-nanomolar range.
Molecular formula C20H13F3N4O2S and molecular weight 430.4 g·mol⁻¹.
High purity (≈99.2% by HPLC) suitable for biochemical assays.
Available in solid and solution formats for assay flexibility.
Used for in vitro and in vivo pharmacology and target validation.
Provided with batch-specific certificate of analysis for QC.

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2,210

eMolecules (2-Amino-3,5-dibromophenyl)methanol | 50739-76-9 | MFCD06202693 | 1g

Combi-Blocks | (2-Amino-3,5-dibromophenyl)methanol | 1g | 439374801 | QN-0025 | 95.000 | 50739-76-9 | MFCD06202693 | 280.947 | C7H7Br2NO

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2,211

Medchemexpress LLC Derenofylline | 251945-92-3 | 99.9% | 308.38 | 50 MG

Derenofylline (SLV 320) is a potent, selective, and orally active adenosine A1 receptor antagonist. It exhibits Ki values of 1 nM for human A1, 200 nM for A3, and 398 nM for A2A receptors. This compound suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats. It has also shown to inhibit TGF-β1-induced myofibroblast transformation in vitro and reduce myocardial fibrosis in vivo.

Potent, selective, and orally active adenosine A1 receptor antagonist
Suppresses cardiac fibrosis
Attenuates albuminuria
Inhibits TGF-β1-induced myofibroblast transformation (in vitro)
Reduces myocardial fibrosis in 5/6 nephrectomy rats (in vivo)

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2,212

eMolecules (2,6-Dibromophenyl)methanol | 1013031-65-6 | MFCD13185492 | 1g

Ambeed | (2,6-Dibromophenyl)methanol | 1g | 552652668 | A214973 | | 1013031-65-6 | MFCD13185492 | 265.932 | C7H6Br2O

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2,213

Apexbio Technology LLC AZ20 1233339-22-4 5mg

AZ20 (CAS 1233339-22-4) is a potent and selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase In biochemical assays AZ20 inhibits ATR with an IC50 of 5 nM in HeLa nuclear extracts and suppresses ATR-mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma cells with an IC50 of 50 nM The compound displays high selectivity for ATR over related kinases such as PI3K isoforms ATM and DNA-PK and minimal activity against mTOR In preclinical models AZ20 demonstrates significant inhibition of tumor growth in LoVo colorectal cancer xenografts following oral administration AZ20 serves as a valuable chemical probe for studying ATR function and the therapeutic potential of ATR inhibition in cancer research

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2,214

Selleck Chemical LLC LY2857785

LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50 0 011 M) and also inhibits other transcription kinases CDK8(IC50 0 016 M) and CDK7 (IC50 0 246 M)

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2,215

Medchemexpress LLC HY-101420 5mg Medchemexpress, VUF10460 CAS:1028327-66-3 Purity:>98%

Medchemexpress, HY-101420 5mg VUF10460 CAS:1028327-66-3 VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pK i of 7.46. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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2,216

Medchemexpress LLC PKI-166 10mg | 187724-61-4 | 330.38 | C20H18N4O | 10 MG

PKI-166 is a potent, selective, and orally bioavailable epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with a reported IC50 of 0.7 nM. It is provided for research use only and has molecular formula C20H18N4O and high purity by HPLC.

Potent EGFR kinase inhibition (IC50 ≈ 0.7 nM).
High chemical purity (≥98% by HPLC).
Suitable for in vitro and in vivo research applications.
Orally bioavailable in preclinical studies.
Well-characterized molecular properties for experimental reproducibility.

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2,217

Medchemexpress LLC mTOR inhibitor-8 | 2489196-70-3 | 98.1% | C24H19ClN4OS | 10MG

mTOR inhibitor-8 is a small-molecule inhibitor of the mechanistic target of rapamycin (mTOR) that acts via FKBP12 to inhibit mTOR activity and induces autophagy in A549 human lung cancer cells. It is provided as a solid research reagent and is available in multiple sizes and solution formats for use in cell-based assays.

Inhibits mTOR activity via FKBP12.
Induces autophagy in A549 human lung cancer cells.
Supplied as a solid and as a 10 mM solution in DMSO for assay flexibility.
High purity (98.1%) suitable for research applications.
Defined chemical formula (C24H19ClN4OS) and molecular weight for accurate identification.

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2,218

Apexbio Technology LLC PKI-402 5MG

PKI-402 5MG APEXBIO TECHNOLOGIES

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2,219

Medchemexpress LLC Methyl-4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl) | 1062169-56-5 | 98.0% | 5 MG

WYE-354 is an ATP-competitive mTOR inhibitor used in research to block mTORC1 and mTORC2 signaling and to study PI3K/mTOR pathway modulation in vitro. It is supplied as a high-purity small molecule in solid form or as a ready-to-use DMSO solution for laboratory assays.

ATP-competitive mTOR inhibitor with IC50 ≈ 5 nM.
High purity suitable for biochemical and cell-based assays.
Available as solid and as a 10 mM solution in DMSO for convenience.
Molecular weight 495.53 g·mol⁻¹ and formula C24H29N7O5.
Commonly used for pathway, signaling, and autophagy research in vitro.

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2,220

Selleck Chemical LLC Dorsomorphin 2HCl

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Pyrimidines And Derivatives

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Medchemexpress LLC Pyrimidin-4-yl-methanol | 33581-98-5 | MFCD03789625 | ≥97.0% | 110.11 g/mol | C5H6N2O | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Derenofylline | 251945-92-3 | 99.9% | 308.38 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC AZ20 1233339-22-4 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-101420 5mg Medchemexpress, VUF10460 CAS:1028327-66-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PKI-166 10mg | 187724-61-4 | 330.38 | C20H18N4O | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC mTOR inhibitor-8 | 2489196-70-3 | 98.1% | C24H19ClN4OS | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC PKI-402 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methyl-4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl) | 1062169-56-5 | 98.0% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More