Pyrimidines And Derivatives
Apexbio Technology LLC 9-cis-Retinoic Acid 5300-03-8 25mg
9-cis-Retinoic Acid (CAS 5300-03-8) is a small-molecule agonist targeting retinoic acid receptors (RARs) and retinoid X receptors (RXRs) It is designed to activate these nuclear receptors thereby regulating transcription of genes involved in cell differentiation immune responses neural function proliferation and reproduction 9-cis-Retinoic Acid exerts its biological activity primarily through RAR/RXR-mediated gene regulation In in vitro studies 9-cis-Retinoic Acid modulates expression of myotrophin (Mptn) and miR-375 in pancreatic -cell and breast cancer cell lines It exhibits nanomolar binding affinity to RAR (Ki 0 5 27 nM) and RXR (Ki 3 8 12 nM) Based on these pharmacological properties 9-cis-Retinoic Acid holds research potential in oncology immunomodulation neuroprotection and dermatological conditions
Medchemexpress LLC PKI(5-24) | 99534-03-9 | 99.99% | 2222.38 | 10 MG
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. It corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor. This 20-residue peptide inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency (Ki of 42 μM) than that of the wild type (Ki of 160 μM). This product is for research use only.
- Potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase)
- Ki of 2.3 nM
- Corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor
- 20-residue peptide synthesized to correspond to the active site of the skeletal muscle inhibitor protein
- Inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency
- For research use only
Medchemexpress LLC Pki 14-22 amide,myristoylated | 201422-03-9 | 99.65% | 1209.49 | 5 MG
Pki 14-22 amide,myristoylated | 201422-03-9 | 99.65% | 1209.49 | 5 MG
Medchemexpress LLC Pki 14-22 amide,myristoylated | 201422-03-9 | 99.7% | 1209.49 | 1 MG
PKI 14-22 amide, myristoylated, is a selective, cAMP-dependent, competitive PKA inhibitor with a Ki of approximately 36 nM. Its myristoylation modification enhances its permeability to cell membranes and blood-brain barriers. This compound can inhibit the phosphorylation of cAMP-dependent downstream targets like CREB and is suitable for research in opioid tolerance mechanisms and antiviral drugs.
- Selective, cAMP-dependent, competitive PKA inhibitor
- Myristoylation enhances cell membrane and blood-brain barrier permeability
- Inhibits phosphorylation of cAMP-dependent downstream targets (e.g., CREB)
- Prevents morphine analgesic tolerance in mice
- Inhibits Zika virus protein translation and RNA synthesis
Medchemexpress LLC Bix-01294 (trihydrochloride) | 1392399-03-9 | MFCD16618384 | 99.7% | 600.02 g/mol | C28H41Cl3N6O2 | 250 MG
BIX-01294 trihydrochloride is a reversible, selective inhibitor of the histone methyltransferases G9a and GLP used for epigenetic research. It reduces H3K9 dimethylation and modulates gene expression and cell behavior in biochemical and cell-based assays; supplied as a light yellow solid with high reported purity.
- Reversible, selective inhibitor of G9a and GLP.
- Active in biochemical and cell assays at low micromolar concentrations.
- Reduces H3K9me2 levels and affects gene expression.
- High reported purity (>99%).
- Soluble in water and DMSO at stated concentrations.
- Powder stable at 4°C; solutions stable with frozen storage per guidance.
eMolecules N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide | 171887-03-9 | MFCD04112936 | 1g
Oakwood Chemical | N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide | 1g | 537699335 | 076859 | | 171887-03-9 | MFCD04112936 | 207.010 | C5H4Cl2N4O
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eMolecules Oakwood Chemical Octanohydroxamic acid 250mg 837487804 227638 0 000 7377-03-9 MFCD00143918 159 229 C8H17NO2
Oakwood Chemical Octanohydroxamic acid 250mg 837487804 227638 0 000 7377-03-9 MFCD00143918 159 229 C8H17NO2