Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1,546

Medchemexpress LLC Sunitinib | 557795-19-4 | MFCD09260778 | 99.04% | 398.5 g/mol | 200 MG

Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor and a small-molecule member of pyrroles and monocarboxylic acid amides. It acts as an antineoplastic agent, an angiogenesis inhibitor, and an immunomodulator. This ATP-competitive inhibitor effectively blocks autophosphorylation of Ire1α, preventing consequent RNase activation.

Targets VEGFR2 with an IC50 of 80 nM
Targets PDGFRβ with an IC50 of 2 nM
Inhibits EC 2.7.10.1 (receptor protein-tyrosine kinase)
Functions as a neuroprotective agent
Acts as a vascular endothelial growth factor receptor antagonist
Approved for treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST)
Approved for adjuvant treatment of recurrent RCC and pancreatic neuroendocrine tumors (pNET)