Pyrroles
Medchemexpress LLC Ac-FEID-CMK TFA | 97.06% | 711.08 | 10 MG
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. It can attenuate the mortality and kidney injury during septic shock and inhibit pyroptosis and attenuate septic AKI (acute kidney injury) in vivo. It can also suppress the caspy2-mediated noncanonical inflammasome pathway.
- Potent zebrafish-specific GSDMEb-derived peptide inhibitor
- Attenuates mortality and kidney injury during septic shock
- Inhibits pyroptosis
- Attenuates septic AKI (acute kidney injury) in vivo
- Suppresses caspy2-mediated noncanonical inflammasome pathway
Medchemexpress LLC Ac-FEID-CMK (TFA) | 97.1% | 711.08 | 1 MG
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. It can attenuate mortality and kidney injury during septic shock, inhibiting pyroptosis and attenuating septic acute kidney injury (AKI) in vivo. It also suppresses the caspy2-mediated noncanonical inflammasome pathway.
- Potent zebrafish-specific GSDMEb-derived peptide inhibitor
- Attenuates mortality and kidney injury during septic shock
- Inhibits pyroptosis
- Attenuates septic acute kidney injury (AKI) in vivo
- Suppresses the caspy2-mediated noncanonical inflammasome pathway
Medchemexpress LLC Kw-8232 | 217813-15-5 | 98.1% | 705.26 g/mol | C37H41ClN4O6S | 50 MG
KW-8232 is an orally active anti-osteoporotic small molecule that reduces prostaglandin E2 (PGE2) biosynthesis in osteoblastic cells and has reported antiviral activity against SARS-CoV-2 (EC50 ≈1.2 μM). Supplied as a solid for research use with reported high purity and recommended storage conditions.
Medchemexpress LLC KH-CB20 | 1354448-60-4 | MFCD00407230 | 99.8% | 338.19 g/mol | C15H13Cl2N3O2 | 5 MG
KH-CB20 is a research-grade small-molecule inhibitor of CDC-like kinases (CLK1 and CLK4). Supplied as an E/Z isomer mixture, it exhibits potent biochemical activity and is provided as a high-purity solid for biochemical and cell-based assays related to splicing and cell-cycle regulation. Refer to the supplier datasheet for experimental and safety information.
- Potent inhibition of CLK1 and CLK4 (CLK1 IC50 16.5 nM).
- Also active against DYRK1A and CLK3.
- High-purity solid suitable for analytical and preparative work.
- Available in milligram quantities and as a DMSO solution.
- Intended for research use only; follow safety and handling guidance.
Medchemexpress LLC HY-120085 5mg Medchemexpress, PFE-360 CAS:1527475-61-1 Purity:>98%
Medchemexpress, HY-120085 5mg PFE-360 CAS:1527475-61-1 PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC 50 of 2.3 nM in vivo [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules Medchem Express / BML-111 / 5mg / 599150032 / HY-100450 / / 78606-80-1 / MFCD00211214 / 192.211 / C8H16O5
Medchem Express / BML-111 / 5mg / 599150032 / HY-100450 / / 78606-80-1 / MFCD00211214 / 192.211 / C8H16O5
Medchemexpress LLC HY-101746 5mg Medchemexpress, GSK376501A CAS:1010412-80-2 Purity:>98%
Medchemexpress, HY-101746 5mg GSK376501A CAS:1010412-80-2 GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-13402 5mg Medchemexpress, Varespladib CAS:172732-68-2 Purity:>98%
Medchemexpress, HY-13402 5mg Varespladib CAS:172732-68-2 Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Osimertinib | 1421373-65-0 | MFCD27988062 | 100 mg
Osimertinib | Purity: 99% | Mol Wt: 499.616 | 1421373-65-0 | MFCD27988062 | 100 mg
Medchemexpress LLC Boc-N-PEG2-MS | 302331-20-0 | 98.0% | C10H21NO6S | 50 MG
Boc-N-PEG2-MS is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
- Purity of 98.0%
- Molecular weight of 283.34
- Chemical formula C10H21NO6S
- Appearance is liquid
- Color is colorless to light yellow
eMolecules Medchem Express / HC-067047 / 5mg / 446255102 / HY-100208 / / 883031-03-6 / MFCD01571257 / 471.524 / C26H28F3N3O2
Medchem Express / HC-067047 / 5mg / 446255102 / HY-100208 / / 883031-03-6 / MFCD01571257 / 471.524 / C26H28F3N3O2
Medchemexpress LLC HY-15650 5mg Medchemexpress, SGC0946 CAS:1561178-17-3 Purity:>98%
Medchemexpress, HY-15650 5mg SGC0946 CAS:1561178-17-3 0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences Metergoline | 17692-51-2 | MFCD00153829 | 5G
Metergoline | Mol Wt: 403.52 | 17692-51-2 | MFCD00153829 | 5G
Medchemexpress LLC KW-8232 | 217813-15-5 | 98.1% | 705.26 | C37H41ClN4O6S | 5 MG
KW-8232 is an orally active anti-osteoporotic small molecule that reduces prostaglandin E2 (PGE2) biosynthesis and decreases markers of bone resorption. In animal models it increases femoral bone mineral density and lowers urinary calcium and collagen crosslinks. Supplied as a solid or as a pre-made DMSO solution for in vitro use.
- Orally active anti-osteoporotic agent with PGE2 inhibition.
- Reduces bone resorption markers such as pyridinoline and deoxypyridinoline.
- Demonstrated to increase femoral bone mineral density in animal models.
- High purity (98.1%) suitable for research applications.
- Soluble in DMSO (approx. 125 mg/mL) for in vitro testing.
- Available as solid and as prepared DMSO solution for convenience.
Medchemexpress LLC HY-15141 2mg Medchemexpress, Staurosporine CAS:62996-74-1 Purity:>98%
Medchemexpress, HY-15141 2mg Staurosporine CAS:62996-74-1 Staurosporine is a potent and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine is an apoptosis inducer[2][3][4][5]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.