Pyrroles
Medchemexpress LLC Ripk1-in-4 | 1481641-08-0 | 98.89% | 401.46 | 100 MG
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase. It binds to a DLG-out inactive form of RIP1 with IC50s of 16 nM for RIP1 and 10 nM for ADP-Glo kinase. This compound is intended for research use only.
- Potent and selective type II kinase inhibitor
- Targets receptor interacting protein 1 (RIP1) kinase
- Binds to a DLG-out inactive form of RIP1
- Inhibits autophosphorylation of RIP1 kinase domain with an IC50 of 0.01 μM
- Prevents TNFalpha/zVAD.fmk-induced necrotic cell death
Selleck Chemical LLC Atorvastatin
Atorvastatin is a lipid lowering agent It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway Atorvastatin activates autophagy
Apexbio Technology LLC Bromoenol lactone 88070-98-8 10mg
Bromoenol lactone (CAS 88070-98-8) is an irreversible inhibitor of cytosolic calcium-independent phospholipase A2 (iPLA2) an enzyme involved in the regulation of arachidonic acid release and lysophospholipid production iPLA2 activity is associated with phospholipid remodeling and the generation of signaling molecules that modulate processes such as eicosanoid synthesis insulin secretion apoptosis and cellular proliferation In cellular assays bromoenol lactone induces apoptosis in various cell lines and promotes proteolysis of procaspase-9 and procaspase-3 It also inhibits phosphatidic acid phosphohydrolase activity and disrupts triacylglycerol biosynthesis in macrophage models Bromoenol lactone is widely utilized in studies investigating lipid signaling cell death mechanisms and metabolic pathways
Medchemexpress LLC Pyrrole-2-carboxaldehyde | 1003-29-8 | 99.99% | C₅H₅NO | 1 G
Pyrrole-2-carboxaldehyde (2-Formylpyrrole) is a five-membered N-heterocyclic system that exhibits distinct vibrational and electronic characteristics. It is observed in a dimeric form in the solid phase and a monomeric form in solution.
- Five-membered N-heterocyclic system
- Pyrrole group acts as a proton donor
- Carbonyl group functions as a proton acceptor
- Exhibits vibrational and electronic characteristics
- Exists as a dimeric form in the solid phase
- Exists as a monomeric form in solution
Medchemexpress LLC HY-18657 100mg Medchemexpress, TEPP-46 ML-265 CAS:1221186-53-3 Purity:98%
Medchemexpress,HY-18657 100mg TEPP-46 ML-265 CAS:1221186-53-3 Formula:C17H16N4O2S2 TEPP-46 is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Atorvastatin (hemicalcium salt) | 134523-03-8 | 99.9% | 577.67 | 500 MG
Atorvastatin hemicalcium salt is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor with blood-brain barrier permeability. It effectively decreases blood lipids and inhibits human SV-SMC proliferation and invasion. This compound reduces apoptosis of myocardial cells by down-regulating GRP78, caspase-12, and CHOP expression, and activates endoplasmic reticulum stress in response to heart failure and angiotensin II stimulation.
- Orally active HMG-CoA reductase inhibitor
- Blood-brain barrier permeable
- Decreases blood lipids
- Inhibits SV-SMC proliferation and invasion
- Reduces apoptosis of myocardial cells
- Activates endoplasmic reticulum stress response
- Inhibits proinflammatory cytokines
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 5mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Apexbio Technology LLC Pizotifen Malate 5189-11-7 100mg
Pizotifen malate (CAS 5189-11-7) is a benzocycloheptane derivative that functions as a potent antagonist of serotonin (5-HT) receptors exhibiting high selectivity for this target class By inhibiting serotonergic neurotransmission Pizotifen malate is utilized in biomedical research to investigate the physiological and pharmacological roles of 5-HT pathways Its receptor blocking properties enable studies focused on serotonergic modulation migraine mechanisms and disorders associated with altered serotonin signaling