Pyrroles
Medchemexpress LLC Almotriptan (malate) | 181183-52-8 | 1 ML
Almotriptan malate is an orally active, highly selective agonist of the 5-HT1B/1D receptor, with potential applications in migraine research. It is suitable for use as a laboratory chemical in the manufacture of substances.
- Highly selective 5-HT1B/1D receptor agonist
- Induces intracranial vasoconstriction
- Inhibits nociceptive neurotransmission in the trigeminocervical complex
- Suppresses release of vasoactive peptides from trigeminal nerve endings
- Solid physical state
- Melting point 170-172°C
eMolecules 1129403-56-0 | Medchem Express | Amcasertib | 5mg | 446268712 | HY-17602 | MFCD30489231 | 539.7 | C31H33N5O2S
Ambeed | (S)-33-Dibromo-11-bi-2-naphthol | 250mg | 588342535 | A390911 | 119707-74-3 | MFCD03093629 | 444.122 | C20H12Br2O2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Apexbio Technology LLC Sunitinib malate(Synonyms: Sutent, SU11248, Sunitinib L-malate, Sunitinib malate salt, SU-11248 malate, Sutent malate), 2g, CAS: 341031-54-7.
Sunitinib malate (CAS 341031-54-7) is a small molecule orally bioavailable multitargeted receptor tyrosine kinase inhibitor It inhibits various receptor tyrosine kinases including platelet-derived growth factor receptor (PDGFR) vascular endothelial growth factor receptors (VEGFR-1 2 and 3) c-KIT FLT3 kinase colony-stimulating factor-1 receptor (CSF-1R) and RET kinase In neuroblastoma cell lines (e g SK-N-BE(2) SH-SY5Y LAN-5) treatment with sunitinib malate significantly suppresses proliferation in a dose-dependent manner (IC50 10-20 ng/ml) Preclinical studies show tumor growth inhibition and reduced metastasis in neuroblastoma mouse models highlighting its potential for research in oncology therapeutics
Medchemexpress LLC Pizotifen malate | 5189-11-7 | 99.0% | C23H27NO5S | 100 MG
Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist with high affinity for the 5-HT1C binding site. It acts as an antidepressant 5-HT2A receptor antagonist, capable of inhibiting serotonin-enhanced ADP-induced platelet aggregation. This product is intended for research use only and is not sold to patients.
- Potent 5-HT2 receptor antagonist
- High affinity for the 5-HT1C binding site
- Antidepressant 5-HT2A receptor antagonist
- Inhibits serotonin-enhanced ADP-induced platelet aggregation
- Intended for research use only
Medchemexpress LLC Atorvastatin lactone | 125995-03-1 | MFCD00899262 | 96.7% | 540.62 g·mol-1 | C33H33FN2O4 | 5 MG
Atorvastatin lactone is the lactone (prodrug) form of atorvastatin, acting as an HMG-CoA reductase inhibitor used in research on cholesterol biosynthesis, statin metabolism, and enzymatic assays. Supplied as a purified solid, it is typically prepared as a DMSO stock for in vitro and analytical applications.
- Prodrug/lactone form of atorvastatin for metabolic and pharmacology studies.
- High purity suitable for analytical and biochemical assays.
- Powder form; soluble in DMSO for stock preparations.
- Molecular weight approximately 540.62 g·mol-1.
- Used as an HMG-CoA reductase inhibitor in research applications.
Cayman Chemical RBromoenol lactone
A selective iPLA2γ inhibitor (IC50 = ~0.6 µM); selective for iPLA2γ over iPLA2β at 20-30 µM
Medchemexpress LLC 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-2-methoxybenzamide;2-hydroxybutanedioic acid | 57645-91-7 | MFCD01743960 | 99.4% | 507.96 | C24H30ClN3O7 | 10 MG
Clebopride malate is the malate salt of clebopride, an orally active dopamine D2 receptor antagonist supplied as a research-grade analytical standard for laboratory pharmacology and analytical studies. It is provided as a high-purity solid intended for controlled experimental use and should be stored sealed and away from moisture; solutions may be frozen for extended storage.
- Malate salt form of clebopride.
- Orally active dopamine D2 receptor antagonist.
- High purity suitable for analytical applications.
- Supplied in a small research-grade pack for laboratory use.
- Stable when stored sealed and away from moisture; follow refrigerated or frozen conditions for solutions.
Medchemexpress LLC Sunitinib | 557795-19-4 | MFCD09260778 | 99.04% | 398.5 g/mol | 200 MG
Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor and a small-molecule member of pyrroles and monocarboxylic acid amides. It acts as an antineoplastic agent, an angiogenesis inhibitor, and an immunomodulator. This ATP-competitive inhibitor effectively blocks autophosphorylation of Ire1α, preventing consequent RNase activation.
- Targets VEGFR2 with an IC50 of 80 nM
- Targets PDGFRβ with an IC50 of 2 nM
- Inhibits EC 2.7.10.1 (receptor protein-tyrosine kinase)
- Functions as a neuroprotective agent
- Acts as a vascular endothelial growth factor receptor antagonist
- Approved for treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST)
- Approved for adjuvant treatment of recurrent RCC and pancreatic neuroendocrine tumors (pNET)
Medchemexpress LLC Atorvastatin ethyl ester | 1146977-93-6 | MFCD28143549 | 98.2% | C35H39FN2O5 | 10MG
Atorvastatin ethyl ester is an ethyl-ester derivative of atorvastatin supplied for research use. It strongly inhibits 9-cis-retinoic acid-induced Gal4 reporter activity and is used as a biochemical probe and analytical reference. The compound has molecular formula C35H39FN2O5, CAS 1146977-93-6, and a molecular weight of 586.69 g·mol⁻¹.
- Inhibits 9-cis-RA-induced Gal4 reporter activity.
- Provided in multiple small-scale pack sizes for laboratory research.
- High reported purity (98.16%).
- Molecular formula C35H39FN2O5 and molecular weight 586.69 g·mol⁻¹.
- Intended for research use only; not for human or veterinary use.
AdipoGen Sunitinib . malate (5 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
Cayman Chemical 4-hydroxy Atorvastatin lacton
A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4
Medchemexpress LLC (-)-Corey lactone diol | 32233-40-2 | 172.18 | 500 MG
(-)-Corey lactone diol is an analytical standard and pharmaceutical intermediate. It is the reduced form of Corey aldehyde and serves as a building block in chemical synthesis. This product is intended for research and analytical applications, including use as a reference standard in HPLC, GC, and MS for qualitative, quantitative, and methodological research.
- Analytical standard for research and analytical applications
- Reduced form of corey aldehyde
- Pharmaceutical intermediate in synthesis
- Reference standard in HPLC, GC, and MS studies
- Building block in chemical synthesis
- Suitable as a laboratory chemical
Cayman Chemical RBromoenol lactone
A selective iPLA2γ inhibitor (IC50 = ~0.6 µM); selective for iPLA2γ over iPLA2β at 20-30 µM
Medchemexpress LLC Atorvastatin epoxy tetrahydrofuran impurity | 873950-19-7 | MFCD31700699 | 96.0% | C26H24FNO5 | 10MG
Atorvastatin epoxy tetrahydrofuran impurity is an oxidative degradation product of atorvastatin provided as an analytical reference standard for research use. Supplied in milligram quantities, it supports impurity profiling, method development, and stability testing. Users should consult the lot-specific Certificate of Analysis for purity and storage conditions.
- Used as an impurity reference for analytical method development.
- Suitable for stability studies and degradation profiling.
- Provided in small, laboratory-scale quantities for research use.
- Chemical formula C26H24FNO5 and CAS 873950-19-7 for unambiguous identification.
- Lot-specific purity and storage conditions available in the Certificate of Analysis.
Medchemexpress LLC Nemonoxacin malate | 951163-60-3 | 99.3% | 505.52 | 10 MG
Nemonoxacin malate is a nonfluorinated quinolone antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens. It can inhibit drug-resistant *Streptococcus pneumoniae* and Methicillin-resistant *Staphylococcus aureus*, and is used for research of community-acquired pneumonia. In vitro, it shows antibacterial activity against *Chlamydia pneumoniae* with MIC90s of 0.06 μg/mL, and is highly active against community-acquired MRSA (CA-MRSA).
- Nonfluorinated quinolone antibiotic
- Broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens
- Inhibits drug-resistant *Streptococcus pneumoniae*
- Inhibits Methicillin-resistant *Staphylococcus aureus*
- Used for research of community-acquired pneumonia
- Antibacterial activity against *Chlamydia pneumoniae*
- Highly active against community-acquired MRSA (CA-MRSA)