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Filtered Search Results
Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG
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PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader. It selectively degrades CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other. This compound consists of a VHL ligand, a CRBN ligand, and a linker, and is intended for research use only.
- Selectively degrades CRBN.
- Binds two E3 ubiquitin ligases (VHL and CRBN) to each other.
- Exhibits rapid degradation of CRBN (DC50=200 nM) in HeLa cells.
- Shows relatively weaker degrading activity against VHL proteins.
- Consists of a VHL ligand, a CRBN ligand, and a linker.
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eMolecules 1280214-48-3 | 5-tert-butoxycarbonyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-3-carboxylic acid | Synthonix | MFCD22571359 | 267.285 | C12H17N3O4 | 97.000 | CC(C)(C)OC(=O)N1CCn2ncc(C(O)=O)c2C1 | 100mg | 808542809
5-tert-butoxycarbonyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-3-carboxylic acid | Synthonix | 1280214-48-3 | MFCD22571359 | 267.285 | C12H17N3O4 | 97.000 | CC(C)(C)OC(=O)N1CCn2ncc(C(O)=O)c2C1 | 100mg | 808542809
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eMolecules 303752-38-7 | 3-([(tert-Butoxy)carbonyl]amino)bicyclo[1.1.1]pentane-1-carboxylic acid | Combi-Blocks, Inc. | MFCD09971715 | 227.260 | C11H17NO4 | 98.000 | CC(C)(C)OC(=O)NC12CC(C1)(C2)C(O)=O | 10g | 574103022
3-([(tert-Butoxy)carbonyl]amino)bicyclo[1.1.1]pentane-1-carboxylic acid | Combi-Blocks, Inc. | 303752-38-7 | MFCD09971715 | 227.260 | C11H17NO4 | 98.000 | CC(C)(C)OC(=O)NC12CC(C1)(C2)C(O)=O | 10g | 574103022
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Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized in PROTAC EED degrader-1 (HY-130614), which is a PROTAC targeting EED with a pKD of 9.02.
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Medchemexpress LLC O-proparagyl-N-Boc-ethanolamine | 634926-63-9 | MFCD22418470 | 95.0% | 199.25 g/mol | C10H17NO3 | 500 MG
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O-Proparagyl-N-Boc-ethanolamine is a Boc-protected ethanolamine bearing a propargyl (alkyne) functional group. It serves as a synthetic building block and alkyne handle for organic synthesis, enabling conjugation via click chemistry and incorporation as a linker or crosslinker in medicinal chemistry applications. Supplied as a solid reagent for routine laboratory synthesis and derivatization.
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Aobchem AOBCHEM
5001069452 2 5-DIFLUORO-4- HYDROXYMETHYL
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000404045 METHYL N-BOC-3-CHLOR 5G
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Medchemexpress LLC 1-Boc-3-aminopyrrolidine | 186550-13-0 | 99.9% | 186.25 | 10 G
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1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is intended for research use only.
- Biochemical reagent for life science research
- Suitable as a biological material
- Suitable as an organic compound
- Not for sale to patients
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000771915 1-ACETYLPYRROLIDINE 1G
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Chem-Impex International, Inc. p-Nitrophenylacetic acid N-hydroxyuccinimide ester | MFCD00047124 | 5G
p-Nitrophenylacetic acid N-hydroxyuccinimide ester, MFCD00047124, 5G
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Aobchem AOBCHEM
5000995730 N - 1- 2 5-DIFLUOROPHENYL ETHY
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Medchemexpress LLC BnO-PEG4-Boc | 500MG
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BnO-PEG4-Boc | 500MG
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Medchemexpress LLC N- t-Boc-Aminooxy-PE | 250MG
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N- t-Boc-Aminooxy-PE | 250MG
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eMolecules 252881-74-6 | NH2-PEG3-C2-Boc | ChemScene | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 250mg | 791178673
NH2-PEG3-C2-Boc | ChemScene | 252881-74-6 | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 250mg | 791178673
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Medchemexpress LLC Acetic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | 189808-70-6 | ≥98.0% | 250 MG
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NH2-PEG3-C1-Boc, also known as PROTAC Linker 5, is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs, which are compounds designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
- Purity of at least 98.0%
- Appearance is a colorless to light yellow liquid
- Molecular formula is C12H25NO5
- Molecular weight is 263.33
- CAS number is 189808-70-6
- Soluble in DMSO at 100 mg/mL
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