Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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2,311 – 2,325 of 4,594 results

2,311

Medchemexpress LLC Milademetan | 1398568-47-2 | MFCD31692325 | 98.9% | 618.53 g/mol | C30H34Cl2FN5O4 | 1 MG

Milademetan is a potent, orally active small-molecule inhibitor of the MDM2-p53 interaction used in preclinical oncology research. It restores p53 activity and induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type cancer models.

Orally active MDM2-p53 inhibitor suitable for in vitro and in vivo research.
Applicable to acute myeloid leukemia and various solid tumor studies.
Induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type models.
High reported purity for research use (≈98.9%).
Well-characterized molecular properties (molecular weight 618.53 g/mol).

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2,312

eMolecules Medchem Express / BRD4 degrader AT1 / 5mg / 415686705 / HY-111433 / / 2098836-45-2 / [null] / 972.680 / C48H58ClN9O5S3

Medchem Express / BRD4 degrader AT1 / 5mg / 415686705 / HY-111433 / / 2098836-45-2 / [null] / 972.680 / C48H58ClN9O5S3

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2,313

Innovative Research Inc Hmn PAI1 Rcmb Act Btn lbl 1 mg

Human PAI-1 Recombinant Active Biotin Labeled 1 mg - Human PAI-1 Recombinant Active Biotin Labeled from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 and a purity of >95% as determined by SDS-PAGE. More Details Species Human Target PAI-1 Purification Method Affinity purified Purity >95% as determined by SDS-PAGE Analysis Source E. coli Storage Conditions -70C Additional Information Active human PAI-1 biotin labeled by iodoacetamide substitution at the N-terminal cysteine. This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more.

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2,314

New England Biolabs, Inc. NEBridge Ligase MM - 250 rxn

NEBridge Ligase Master Mix is a 3X master mix for Golden Gate Assembly. Designed for use with NEB Type IIS restriction enzymes, this master mix contains T4 DNA Ligase in an optimized reaction buffer with a proprietary ligation enhancer. Users need only choose their preferred NEB Type IIS restriction enzyme and add DNA substrates to be assembled. Low complexity single fragment insertions, as well as moderate complexity (3-6 fragment) and high complexity (7-25 fragment) assemblies, are all supported with this optimized reagent and accompanying protocols.

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2,315

eMolecules (S, R, S)-AHPC-PEG8-acid | | | 500mg

Broadpharm | (S, R, S)-AHPC-PEG8-acid | 500mg | 528284342 | BP-24506 | 98.000 | | | 883.060 | C42H66N4O14S

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2,316

Medchemexpress LLC HY-50846 10mg Medchemexpress, SCH772984 CAS:942183-80-4 Purity:>98%

Medchemexpress, HY-50846 10mg SCH772984 CAS:942183-80-4 SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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2,317

Medchemexpress LLC Protac FAK degrader 1 | 2301916-69-6 | 99.3% | 10 MG

PROTAC FAK degrader 1 is a proteolysis-targeting chimera designed to selectively induce degradation of focal adhesion kinase (FAK) in cellular models, enabling studies of FAK-dependent signaling, migration, and invasion.

Selective FAK degradation with DC50 of 3.0 nM in PC3 cells.
High purity (99.25%) suitable for cellular assays.
Available in small research sample sizes for in vitro use.
Useful for investigating cancer cell migration, invasion, and signaling pathways.

Pricing & Availability

2,318

Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It has IC50s of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound is capable of reducing sex hormone levels and is intended for research use only.

Orally active and selective luteinizing hormone receptor (LH-R) antagonist
Capable of reducing sex hormone levels
IC50 of 96 nM for human LH, 23 nM for rat LH, and 78 nM for cynomolgus monkey LH
Solid appearance
Off-white to light yellow color

Pricing & Availability

2,319

Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG

AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), binding to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis and is for research use only.

Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
Induces apoptosis
Inhibits cell viability in H1975 NSCLC cells
Downregulates cIAP-1 and activates RIPK1
Triggers extrinsic and intrinsic apoptosis pathways
Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in vivo
Leads to substantial tumor regressions in xenograft models

Pricing & Availability

2,320

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG

PROTAC IDO1 Degrader-1 is a research-grade proteolysis targeting chimera (PROTAC) that selectively induces degradation of indoleamine 2,3-dioxygenase 1 (IDO1) by recruiting cereblon E3 ligase, leading to ubiquitination and proteasomal degradation. Cellular studies demonstrate dose-dependent IDO1 degradation and functional enhancement of tumor-killing activity in CAR-T assays.

Induces selective IDO1 degradation in cells (DC50 = 2.84 μM).
Displays IDO1 inhibitory potency (IC50 = 1.07 μM).
Produces up to 93% maximum degradation in HeLa cells.
Soluble in DMSO at 100 mg/mL; in vivo co-solvent formulations reported with ≥2.5 mg/mL solubility.
Store sealed at -20°C; in solution: -80°C up to 6 months, -20°C up to 1 month.
For research use in cellular and in vivo studies.

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2,321

Medchemexpress LLC Protac PD-1/PD-L1 degrader-1 | 2447066-37-5 | 99.5% | C59H58ClN7O11 | 10MG

PROTAC PD-1/PD-L1 degrader-1 is a cereblon-based proteolysis targeting chimera designed to disrupt PD-1/PD-L1 interaction and induce degradation of PD-L1 in cells. It demonstrates potent cellular activity and has been applied in co-culture models to restore immune responses via a lysosome-dependent mechanism.

High purity suitable for cellular and biochemical assays.
Potent cellular activity (IC50 39.2 nM).
Cereblon E3 ligase-mediated degradation mechanism.
Reduces PD-L1 protein levels in a lysosome-dependent manner.
Suitable for studies of immune checkpoint modulation and PD-L1 biology.

Pricing & Availability

2,322

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 10 MG

Milademetan tosylate hydrate is the tosylate salt form of milademetan, an orally active small-molecule inhibitor of the MDM2-p53 interaction used in preclinical oncology research. Supplied as a research-use reagent, it is characterized by CAS 2095625-97-9, a molecular weight of 808.74 g/mol, and supporting documentation for laboratory use.

Salt form (tosylate hydrate) for improved handling and stability.
Orally active MDM2 inhibitor that facilitates p53 pathway reactivation.
High purity suitable for analytical and preclinical studies (98.9%).
Available in small pack sizes suitable for lab-scale experiments.
Includes datasheet, certificate of analysis, and safety information for lab use.

Pricing & Availability

2,323

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 25 MG

Milademetan tosylate hydrate is the tosylate hydrate salt of milademetan, an orally active MDM2 inhibitor used in preclinical research. It disrupts the p53-MDM2 interaction, inducing G1 cell cycle arrest and apoptosis, and is investigated for acute myeloid leukemia and various solid tumor models. For research use only.

Specific MDM2 inhibitor with p53 pathway activity.
Induces G1 cell cycle arrest and apoptosis in preclinical models.
High purity reported (98.89%) on the COA.
Available in small research quantities, including 25 mg packaging.
Supplied with a datasheet and certificate of analysis for traceability.
Chemical identifiers: CAS 2095625-97-9; formula C37H44Cl2FN5O8S.

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2,324

Medchemexpress LLC (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide | 1361321-96-1 | MFCD28502270 | 99.5% | 388.48 g/mol | C20H24N2O4S | 100 MG

ACT-462206 is a brain-penetrant dual orexin receptor antagonist used in preclinical research on insomnia, anxiety-related disorders, and addiction. It exhibits potent activity at orexin receptors and is supplied as a high-purity research chemical for laboratory studies. Not for human or veterinary use.

Dual orexin receptor antagonist (OX1 and OX2)
Brain-penetrant compound suitable for CNS research
Potent activity: IC50 ≈ 60 nM (OX1), ≈ 11 nM (OX2)
High purity suitable for laboratory use
Storage: protect from light; in solvent store at -80°C (6 months) or -20°C (1 month)
Available as solid or as 10 mM solution in DMSO

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2,325

eMolecules Medchem Express / Alarelin (Acetate) / 10mg / 446268350 / HY-17405 / / 79561-22-1 / MFCD30207842 / 1287.444 / C60H86N16O16

Medchem Express / Alarelin (Acetate) / 10mg / 446268350 / HY-17405 / / 79561-22-1 / MFCD30207842 / 1287.444 / C60H86N16O16

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Pyrrolidines

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Medchemexpress LLC Milademetan | 1398568-47-2 | MFCD31692325 | 98.9% | 618.53 g/mol | C30H34Cl2FN5O4 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

New England Biolabs, Inc. NEBridge Ligase MM - 250 rxn Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-50846 10mg Medchemexpress, SCH772984 CAS:942183-80-4 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Protac FAK degrader 1 | 2301916-69-6 | 99.3% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Protac PD-1/PD-L1 degrader-1 | 2447066-37-5 | 99.5% | C59H58ClN7O11 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide | 1361321-96-1 | MFCD28502270 | 99.5% | 388.48 g/mol | C20H24N2O4S | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More