Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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2,326 – 2,340 of 6,176 results

2,326

eMolecules 1948273-02-6 | E3 LIGASE LIGAND 1A | AstaTech444.590 | C23H32N4O3S | 95.000 | C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C | 0.25g | 573027259

E3 LIGASE LIGAND 1A | AstaTech | 1948273-02-6444.590 | C23H32N4O3S | 95.000 | C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C | 0.25g | 573027259

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2,327

Medchemexpress LLC (R,s)-((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-(4-((4s,5r)-4,5-bis(4-chlorophen | 2249750-23-8 | 95.0% | 1437.25 g/mol | C72H78Cl4N8O15 | 5 MG

PROTAC MDM2 Degrader-3 is a proteolysis-targeting chimera (PROTAC) designed to induce selective degradation of MDM2 by recruiting an E3 ubiquitin ligase, enabling proteasomal removal of the target protein. It is formulated as a solid research reagent intended for in vitro studies and is supplied with batch-specific analytical documentation.

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2,328

eMolecules 1206524-86-8 | Medchem Express | Grazoprevir potassium salt | 5mg | 446265389 | HY-15298A | MFCD25976701 | 805 | C38H49KN6O9S

Ambeed | 6-(Methoxycarbonyl)-3-methyl-1H-indole-2-carboxylic acid | 250mg | 682931810 | A766549 | 1290069-58-7 | MFCD20230033 | 233.223 | C12H11NO4

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2,329

Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG

WSB1 Degrader 1 is a potent and orally active WSB1 (WD repeat and SOCS box-containing 1) degrader, exhibiting anticancer metastatic effects.

Induces WSB1 degradation in H1299-WSB1 cells.
Exhibits potent antimigration efficacy in KHOS and H460 cell lines.
Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells.
Elevates RhoGDI2 protein levels in KHOS cells under hypoxia.
Significantly inhibits wound-healing of H1299-WSB1 cells.
Blocks wound-healing capability of wild-type A2780 cells.
Effectively inhibits pulmonary metastasis of cancer cells in mice bearing highly metastatic 4T1 breast cancer cells.
Shows quick absorption and acceptable blood exposure in rats after oral or intraperitoneal dosing.

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2,330

Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG

PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader. It selectively degrades CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other. This compound consists of a VHL ligand, a CRBN ligand, and a linker, and is intended for research use only.

Selectively degrades CRBN.
Binds two E3 ubiquitin ligases (VHL and CRBN) to each other.
Exhibits rapid degradation of CRBN (DC50=200 nM) in HeLa cells.
Shows relatively weaker degrading activity against VHL proteins.
Consists of a VHL ligand, a CRBN ligand, and a linker.

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2,331

Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 50 MG

(S,R,S)-AHPC-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. It is for research use only.

Synthesized E3 ligase ligand-linker conjugate
Incorporates (S,R,S)-AHPC based VHL ligand
Uses 5-unit PEG linker
Utilized in PROTAC technology
Recruits VHL protein, a substrate recognition subunit of E3 ubiquitin ligase complexes
Induces ubiquitination and subsequent proteasomal degradation of target protein

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2,332

Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98%

Medchemexpress, HY-101763A 500mg (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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2,333

Medchemexpress LLC S R S -AHPC-Me-C5-C | 100MG

S R S -AHPC-Me-C5-C | 100MG

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2,334

eMolecules 904763-27-5 | Medchem Express | ATN-161 (trifluoroacetate salt) | 5mg | 446263078 | HY-13535A | MFCD28167827 | 711.67 | C25H36F3N9O10S

Medchem Express | ATN-161 (trifluoroacetate salt) | 5mg | 446263078 | HY-13535A | 904763-27-5 | MFCD28167827 | 711.670 | C25H36F3N9O10S

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2,335

Aobchem AOBCHEM

5001081681 4-BROMO-3- PYRROLIDINE-1-CARB

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2,336

Aobchem 6-(Bis(tert-butoxycarbonyl)amino)pyridin-3-ylboronic acid | ≥97% | CAS 1229653-05-7 | C15H23BN2O6 | 250mg

6-(Bis(tert-butoxycarbonyl)amino)pyridin-3-ylboronic acid | ≥97% | CAS 1229653-05-7 | C15H23BN2O6 | 250mg

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2,337

Aobchem 6-(Bis(tert-butoxycarbonyl)amino)pyridin-3-ylboronic acid | ≥97% | CAS 1229653-05-7 | C15H23BN2O6 | 1g

6-(Bis(tert-butoxycarbonyl)amino)pyridin-3-ylboronic acid | ≥97% | CAS 1229653-05-7 | C15H23BN2O6 | 1g

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2,338

Aobchem 1-(2-Bromobenzyl)pyrrolidine | ≥97% | CAS 91130-46-0 | C11H14BrN | 5g

1-(2-Bromobenzyl)pyrrolidine | ≥97% | CAS 91130-46-0 | C11H14BrN | 5g

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2,339

eMolecules 71066-00-7 | 2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid | Oakwood Chemicals | MFCD00800597 | 277.320 | C15H19NO4 | 99.000 | CC(C)(C)OC(=O)NC1(Cc2ccccc2C1)C(O)=O | 250mg | 480168548

2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid | Oakwood Chemicals | 71066-00-7 | MFCD00800597 | 277.320 | C15H19NO4 | 99.000 | CC(C)(C)OC(=O)NC1(Cc2ccccc2C1)C(O)=O | 250mg | 480168548

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2,340

eMolecules (S)-2-Azido-3-phenylpropionic acid dicyclohexylammonium salt | Chem-Impex |372.513 | C21H32N4O2 | 98.000 | C1CCC(CC1)NC1CCCCC1.OC(=O)C(Cc1ccccc1)N=[N+]=[N-] | 250mg | 490843728

(S)-2-Azido-3-phenylpropionic acid dicyclohexylammonium salt | Chem-Impex |372.513 | C21H32N4O2 | 98.000 | C1CCC(CC1)NC1CCCCC1.OC(=O)C(Cc1ccccc1)N=[N+]=[N-] | 250mg | 490843728

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Pyrrolidines

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Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC S R S -AHPC-Me-C5-C | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG

Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG

Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 50 MG

Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98%

Medchemexpress LLC S R S -AHPC-Me-C5-C | 100MG