Pyrrolidines
Medchemexpress LLC Boc-Aminooxy-PEG4-NH2 | 2062663-66-3 | 95.0% | C13H28N2O7 | 250 MG
Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules are instrumental in drug discovery, facilitating the targeted degradation of specific proteins. By leveraging the intracellular ubiquitin-proteasome system, PROTACs offer a novel approach to modulating protein function.
- Peg-based protac linker
- Used in the synthesis of protacs
- Facilitates targeted protein degradation
- Utilizes the ubiquitin-proteasome system
Medchemexpress LLC Boc-Aminooxy-PEG4-NH2 | 2062663-66-3 | 95.0% | C13H28N2O7 | 100 MG
Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Utilizes intracellular ubiquitin-proteasome system
Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 50 MG
WSB1 Degrader 1 is a potent and orally active degrader of WSB1 (WD repeat and SOCS box-containing 1). It exhibits anticancer metastatic effects. In vitro studies show it induces WSB1 degradation in H1299-WSB1 cells in a time-dependent and dose-dependent manner. It also demonstrates potent antimigration efficacy in KHOS and H460 cell lines. In vivo, daily oral treatment effectively inhibited pulmonary metastasis in Balb/c (nu/nu) mice bearing highly metastatic 4T1 breast cancer cells.
- Induces WSB1 degradation in H1299-WSB1 cells
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia
- Blocks the wound-healing capability of wild-type A2780 cells
- Effectively inhibits pulmonary metastasis of cancer cells in animal models
Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG
WSB1 Degrader 1 is a potent and orally active WSB1 (WD repeat and SOCS box-containing 1) degrader, exhibiting anticancer metastatic effects.
- Induces WSB1 degradation in H1299-WSB1 cells.
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines.
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells.
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia.
- Significantly inhibits wound-healing of H1299-WSB1 cells.
- Blocks wound-healing capability of wild-type A2780 cells.
- Effectively inhibits pulmonary metastasis of cancer cells in mice bearing highly metastatic 4T1 breast cancer cells.
- Shows quick absorption and acceptable blood exposure in rats after oral or intraperitoneal dosing.
eMolecules AstaTech / 22-DIMETHYL-3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID ETHYL ESTER / 1g / 112526618 / 60570 / 97.000 / 106556-66-5 / MFCD09835297 / 185.223 / C9H15NO3
AstaTech / 22-DIMETHYL-3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID ETHYL ESTER / 1g / 112526618 / 60570 / 97.000 / 106556-66-5 / MFCD09835297 / 185.223 / C9H15NO3