Quinolines and derivatives

Apexbio Technology LLC Penicillin V potassium salt 132-98-9 200mg

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Penicillin V potassium salt (132-98-9) is a small-molecule inhibitor targeting bacterial cell wall peptidoglycan synthesis It is designed to inhibit this biosynthetic pathway thereby suppressing the growth of Gram-positive bacteria Penicillin V potassium salt exerts its biological activity primarily through inhibition of bacterial cell wall synthesis In microbial susceptibility assays Penicillin V potassium salt demonstrates inhibitory effects with IC50 values ranging from approximately 0 01 to 0 5 g/mL for sensitive bacterial strains Based on these pharmacological properties Penicillin V potassium salt holds research potential in studies investigating Gram-positive bacterial resistance mechanisms cell-wall targeting antibiotic actions and experimental models of upper respiratory tract infections including otitis media sinusitis pharyngitis and tonsillitis

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Apexbio Technology LLC Temsirolimus 162635-04-3 200mg

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Temsirolimus (CCI-779) is an ester analog of rapamycin functioning as an inhibitor of the mammalian target of rapamycin (mTOR) The compound suppresses mTOR signaling pathways thus inhibiting cellular proliferation and growth In preclinical studies on breast cancer cell lines Temsirolimus displayed inhibitory activities with reported IC50 values of 0 6 nM in BT-474 cells 0 7 nM in MDA-MB-468 and SKBR-3 cells and 50 nM in MCF-7 cells It has been examined in xenograft models of tumors with PTEN mutations and multiple myeloma for investigating pathways related to cell-cycle progression and proliferation regulated by mTOR

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC Cyclopamine | 4449-51-8 | 411.62 | 200 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Cyclopamine is a steroidal alkaloid and a selective Smo inhibitor that acts as a Hedgehog (Hh) pathway antagonist, with an IC50 of 46 nM in Hh cell assays. It is used in research for its ability to suppress cell growth and inhibit Hh signaling.

• Hedgehog (Hh) pathway antagonist
• Selective Smo inhibitor
• Suppresses cell growth
• Inhibits Hh signaling through direct interaction with Smo
• Suitable for research and analytical applications
• Induces tumor remission in medulloblastoma models
• Blocks tumor formation in pancreatic adenocarcinoma cells

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC Sapitinib | 848942-61-0 | 200 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor with IC50s of 4, 3, and 4 nM for EGFR, ErbB2, and ErbB3 in cells, respectively. It demonstrates potent inhibitory effects on erbB2 in ligand-independent MCF-7 cl24 cells, significantly inhibits Akt phosphorylation, and induces apoptosis in human IBC cells.

• Reversible, ATP competitive EGFR inhibitor
• Potent inhibitory effect on erbB2 in ligand-independent MCF-7 cl24 cells
• Significantly inhibits phosphorylation of Akt in SUM149 and FC-IBC-02 cells
• Inhibits proliferation and induces apoptosis in human IBC cells
• Active in xenograft tumor models responsive to EGFR inhibition alone or EGFR or erbB2 inhibition
• Causes pharmacodynamic changes in proliferation and apoptosis markers in human tumor xenograft models
• Favorable oral pharmacokinetics in rat and dog
• Low human hepatocyte turnover

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC 9-(oxolan-2-yl)purin-6-amine | 17318-31-9 | MFCD00210216 | ≥98.0% | 205.22 g/mol | C9H11N5O | 200 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

SQ22536 is a small-molecule adenylate cyclase inhibitor used in research to modulate cAMP signaling. It is provided as a powder and is characterized by CAS 17318-31-9, molecular formula C9H11N5O, and molecular weight 205.22 g/mol. The compound is suitable for laboratory-scale in vitro and in vivo studies with documented solubility and storage recommendations.

• Potent adenylate cyclase inhibitor for cAMP pathway studies.
• Suitable for in vitro and in vivo applications with established vehicle formulations.
• Soluble in DMSO and water at experimentally useful concentrations.
• Stable as a powder under cold storage with multi-year shelf life.
• Provided as an analytical standard for research use only.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Apexbio Technology LLC WAY-100635 162760-96-5 200mg

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC Ml-18 | 1422269-30-4 | MFCD30182327 | 98.9% | 569.65 g/mol | C32H35N5O5 | 200 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

ML-18 is a small-molecule, non-peptide antagonist of bombesin receptor subtype-3 (BRS-3) used for receptor binding and cellular signaling research. It inhibits BRS-3 binding in cell-based assays with an IC50 of 4.8 μM, shows lower affinity at GRPR (IC50 16 μM), and minimal activity at NMBR (>100 μM).

• Non-peptide antagonist of BRS-3 for receptor and signaling studies.
• Validated potency: IC50 4.8 μM at BRS-3.
• Lower off-target affinity: IC50 16 μM (GRPR), >100 μM (NMBR).
• Chemical formula C32H35N5O5; molecular weight 569.65 g/mol.
• High purity solid (98.87%), available in solid and DMSO solution formats.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Cell Signaling Technology G-alpha-(q) (D5V1B) Rabbit mAb 20 ul

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

G-alpha-(q) (D5V1B) Rabbit mAb 20 ul

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ 8-(TRIFLUOROMETHOXY)QUINOLIN-3-AMINE | 2092339-50-7 | | 1g

AstaTech | 8-(TRIFLUOROMETHOXY)QUINOLIN-3-AMINE | 1g | 410713966 | K10170 | 95.000 | 2092339-50-7 | | 228.174 | C10H7F3N2O

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool