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Filtered Search Results
Medchemexpress LLC (S,R,S)-AHPC-amido-C7-acid | 2172819-76-8 | 98.7% | 600.77 | 25 MG
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(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker, making it suitable for PROTAC development and research applications.
- Incorporates a VHL ligand and a PROTAC linker
- Suitable for research applications
- Designed for PROTAC development
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Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 200 MG
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Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro. Intended for research use only, it undergoes hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP3A4 substrates. It has been shown to reduce plasma concentrations of low-density lipoprotein cholesterol (LDL-C) by more than 50%.
- Target: microsomal triglyceride-transfer protein (MTP)
- IC50: 8 nM (MTP) in vitro
- Metabolism: hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4
- Bioavailability: 7.1% for the 50-mg capsule
- Half-life: 39.7 hours
- Appearance: white to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solvent storage: -80°C for 2 years, -20°C for 1 year
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379128 PRACINOSTAT 200MG
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Medchemexpress LLC Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430587 ICARIIN 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430687 ACRIDINE ORANGE 10-N 10MM 1ML
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.88% | 1 G
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Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone veterinary drug with broad-spectrum bactericidal activity. It primarily inhibits the DNA gyrase of bacteria and is a substrate for ATP-dependent efflux transporters (P-gp and MRP2). It is designed for laboratory research.
- Fluoroquinolone veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
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Medchemexpress LLC Amino-PEG8-amine | 82209-36-7 | 98.0% | 500 MG
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Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Appears as liquid
- Color is colorless to light yellow
- Molecular weight: 412.52
- Molecular formula: C18H40N2O8
- CAS number: 82209-36-7
- Purity: 98.0%
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month (protected from light)
- Soluble in DMSO at 100 mg/mL
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Medchemexpress LLC m-PEG9-Amine | 211859-73-3 | >97.0% | 5 G
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m-PEG9-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs, and also functions as a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It facilitates the construction of compounds that either selectively degrade target proteins via the ubiquitin-proteasome system or enable targeted delivery of cytotoxic drugs.
- Functions as a PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Acts as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Supports targeted protein degradation via the ubiquitin-proteasome system
- Enables targeted delivery of cytotoxic drugs
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Medchemexpress LLC 7-Hydroxycarbostyril | 70500-72-0 | 99.05% | 161.16 | 25 G
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7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) is a quinolinone derivative. This compound is utilized in the synthesis of brexpiprazole, an orally active antipsychotic agent that functions as a partial agonist for both human 5-HT1A and dopamine D2L receptors.
- A quinolinone derivative.
- Used for the synthesis of brexpiprazole.
- High purity: 99.05%.
- For research use only.
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Medchemexpress LLC 7-Deazaguanine | 7355-55-7 | HY-34222 | 99.73% | 150.14 | 25 G
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7-Deazaguanine (Compound 1) is a highly selective, well-tolerated, brain-penetrant DYRK1A inhibitor. It is promising for research of cancers and Down's syndrome.
- Highly selective DYRK1A inhibitor
- Well-tolerated
- Brain-penetrant
- Promising for research of cancers
- Promising for research of Down's syndrome
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Medchemexpress LLC 5-Hydroxyquinoline | 578-67-6 | 99.5% | 145.16 | 25 G
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5-Hydroxyquinoline is an organic compound used in various chemical reactions and biological research. It finds application in the manufacture of dyes, cellulase, oxidants, and passivators, and is extensively utilized in the pigment, paint, and rubber industries. Additionally, it serves as a precursor, intermediate, and metal ion complexing agent for certain drugs, and is a biochemical reagent for life science-related research.
- Used in the manufacture of dyes, cellulase, oxidants, and passivators
- Extensively utilized in the pigment, paint, and rubber industries
- Serves as a precursor, intermediate, and metal ion complexing agent for drugs
- Biochemical reagent for life science-related research
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Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG
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L-Azidonorleucine hydrochloride is an unnatural amino acid that serves as a methionine surrogate. It is used to label mammalian cell proteins and identify various methionyl-tRNA synthetase (MetRS) mutants. This compound functions as a click chemistry reagent due to its azide group, which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Unnatural amino acid and methionine surrogate
- Labels mammalian cell proteins
- Identifies methionyl-tRNA synthetase (MetRS) mutants
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Strong inhibitor of brain nitric oxide synthase (NOS)
- Potent inhibitor of CYP3A4
- Shows anti-immobility action in mice (in FST and TST)
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
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Medchemexpress LLC Alectinib 200mg | 200MG
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Alectinib 200mg | 200MG
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