Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC SM-164 957135-43-2 200mg
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SM-164 (CAS 957135-43-2) is a bivalent small molecule mimetic of the endogenous inhibitor Smac designed to antagonize cellular inhibitor of apoptosis proteins (cIAP-1 cIAP-2) and X-linked inhibitor of apoptosis protein (XIAP) By binding specifically to the BIR2 and BIR3 domains of cIAP-1 and XIAP as well as the BIR3 domain of cIAP-2 (Ki of 0 31 nM 0 56 nM and 1 1 nM respectively) SM-164 promotes degradation of cIAP-1 and inhibition of XIAP In tumor cells this leads to caspase activation and TNF -dependent apoptosis SM-164 is utilized in cancer research to investigate apoptosis regulation and anticancer therapy strategies
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Apexbio Technology LLC JNJ-26481585 875320-29-9 200mg
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JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment
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Sigma Aldrich Fine Chemicals Biosciences Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | 51773-92-3 | MFCD00797519 | 100MG
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 414.77 | 51773-92-3 | MFCD00797519 | 100MG
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Apexbio Technology LLC AMG-900 945595-80-2 200mg
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AMG-900 (CAS 945595-80-2) is a small-molecule inhibitor targeting Aurora kinases a group of serine/threonine kinases crucial for mitosis regulation It exhibits potent ATP-competitive inhibitory activity against all three Aurora kinase isoforms resulting in suppression of Aurora-A and Aurora-B autophosphorylation events AMG-900 induces disruption of cellular mitotic processes leading to cell cycle arrest and subsequent apoptotic cell death Preclinically AMG-900 demonstrates activity across multiple tumor cell lines including multidrug-resistant and taxane-resistant variants and inhibits tumor growth in mouse xenograft models suggesting utility for cancer research
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Medchemexpress LLC Prostaglandin H2 (PGH2) | 42935-17-1 | ≥95.0% | 352.47 | 10 UG
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Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor that can cause vasoconstriction. It is the common precursor of all prostaglandins and is produced by several cells that express cyclooxygenases. PGH2 can activate PGD2 receptors CRTH2 and DP by interacting directly with the receptors or by giving rise to PGD2 after catalytic conversion by plasma proteins. It is used in research for inflammation and neurological diseases, such as Alzheimer's disease.
- Increases forward-scatter of eosinophils
- Induces shape changes and Ca2+ production in eosinophils
- Induces migration and collagen-induced platelet aggregation in eosinophils
- Inhibits eosinophil degranulation by activation of CRTH2 receptors
- Accelerates the rate of formation of dimers and higher oligomers of amyloid β1-42
- Induces contraction of rabbit pulmonary artery
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Medchemexpress LLC Anhydrous sodium dih 25g | 25G
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Anhydrous sodium dih 25g | 25G
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eMolecules 72716-87-1 | 2-Methoxy-pyridine-4-carbaldehyde | Ochem Incorporation | MFCD06410680 | 137.138 | C7H7NO2 | 98.000 | COc1cc(C=O)ccn1 | 1g | 773157178
2-Methoxy-pyridine-4-carbaldehyde | Ochem Incorporation | 72716-87-1 | MFCD06410680 | 137.138 | C7H7NO2 | 98.000 | COc1cc(C=O)ccn1 | 1g | 773157178
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Ambeed AMBEED
5000849924 3- QUINOLIN-6-YL -1H-PY 1G
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Medchemexpress LLC 3,6,9,12,15,18-Hexaoxanonadecan-1-amine | 184357-46-8 | ≥97.0% | 10 G
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m-PEG6-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, while ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Used in the synthesis of PROTACs
- Used in the synthesis of antibody-drug conjugates (ADCs)
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Apexbio Technology LLC DGAT-1 inhibitor 701232-20-4 200mg
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DGAT-1 inhibitor (CAS 701232-20-4) also known as T863 is an orally active small molecule that selectively inhibits diacylglycerol acyltransferase 1 (DGAT1) DGAT1 is responsible for catalyzing the final step in triglyceride biosynthesis T863 suppresses enzyme activity by specifically binding to the acyl-CoA binding site of DGAT1 exhibiting an IC50 of 15 nM without affecting enzymatic activities of human DGAT2 MGAT2 or MGAT3 This compound serves as a research tool for investigating DGAT1-mediated lipid synthesis and exploring lipid metabolic disorders using cellular and animal models
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Medchemexpress LLC MSA-2 | 129425-81-6 | 99.8% | 294.32 | 200 MG
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MSA-2 is a potent and orally available non-nucleotide STING agonist that binds to STING as a noncovalent dimer with nanomolar affinity. It stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
- Potent and orally available non-nucleotide STING agonist
- Binds to STING as a noncovalent dimer with nanomolar affinity
- Stimulates interferon-β secretion in tumors
- Induces tumor regression with durable antitumor immunity
- Synergizes with anti-PD-1 in syngeneic mouse tumor models
- Achieves comparable exposure in tumor and plasma
- Exhibits dose-dependent antitumor activity
- Induces elevations of IFN-β, IL-6, and TNF-α in tumors
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Medchemexpress LLC 7-Deazaguanine | 7355-55-7 | HY-34222 | 99.73% | 150.14 | 25 G
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7-Deazaguanine (Compound 1) is a highly selective, well-tolerated, brain-penetrant DYRK1A inhibitor. It is promising for research of cancers and Down's syndrome.
- Highly selective DYRK1A inhibitor
- Well-tolerated
- Brain-penetrant
- Promising for research of cancers
- Promising for research of Down's syndrome
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Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | ≥ 97.0% | 324.41 | 100 MG
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Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker. It can be used in the synthesis of PROTACs, which are molecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
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Aobchem AOBCHEM
5000905417 2- METHYLTHIO THIAZOLE-5-CARBA
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eMolecules 99584-10-8 | 6-Amino-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one | ChemScene | MFCD07801206 | 164.164 | C8H8N2O2 | 95.000 | Cn1c2ccc(N)cc2oc1=O | 250mg | 680025320
6-Amino-3-methyl-2,3-dihydro-1,3-benzoxazol-2-one | ChemScene | 99584-10-8 | MFCD07801206 | 164.164 | C8H8N2O2 | 95.000 | Cn1c2ccc(N)cc2oc1=O | 250mg | 680025320
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