Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,096 – 1,110 of 5,526 results

1,096

Aobchem 3-Methylbenzothiophene-2-carboxaldehyde | ≥95% | CAS 22053-74-3 | C10H8OS | 500mg

3-Methylbenzothiophene-2-carboxaldehyde | ≥95% | CAS 22053-74-3 | C10H8OS | 500mg

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1,097

Aobchem 9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g

9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g

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1,098

Aobchem 2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 10g

2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 10g

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1,099

Apexbio Technology LLC Kobe0065 436133-68-5 200mg

Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms

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1,100

Medchemexpress LLC 7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG

7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG

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1,101

Aobchem 2-Methoxy-8-quinolinecarboxaldehyde | ≥95% | CAS 885687-67-2 | C11H9NO2 | 500mg

2-Methoxy-8-quinolinecarboxaldehyde | ≥95% | CAS 885687-67-2 | C11H9NO2 | 500mg

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1,102

Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G

Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. It has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.

Orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor
Enhances gastric contractility and accelerates delayed gastric emptying
Potential for research of functional dyspepsia and intestinal inflammatory conditions

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1,103

Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 1 MG

CLIP (86-100) is a fragment consisting of amino acids 86 to 100 of the class II-associated invariant chain peptide (CLIP). This small self-peptide is a cleavage product of the invariant chain and resides in the HLA-II antigen binding groove, playing a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.

Consists of amino acids 86 to 100 of the class II-associated invariant chain peptide
Plays a critical role in the assembly and transport of MHC class II alphabetaIi complexes
Purity of 98.49%
Molecular weight: 1674.10
White to off-white solid appearance
Soluble in H2O at ≥ 100 mg/mL
Store as powder at -80°C for 2 years or -20°C for 1 year
Store in solvent at -80°C for 6 months or -20°C for 1 month

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1,104

Apexbio Technology LLC Nifuroxazide 965-52-6 200mg

Nifuroxazide (CAS 965-52-6) is a small-molecule inhibitor targeting signal transducer and activator of transcription (STAT) signaling pathways It is designed to inhibit activation of STAT1 STAT3 and STAT5 thereby suppressing cytokine-mediated transcriptional activities Nifuroxazide exerts its biological activity primarily through inhibition of STAT phosphorylation and activation In cell-based assays Nifuroxazide demonstrates inhibitory activity with an IC50 value of approximately 3 M against STAT3 phosphorylation and activation in IL-6-stimulated U3A cells Based on these pharmacological properties Nifuroxazide holds research potential in studies of STAT-driven signaling processes and in exploring therapeutic strategies for diseases associated with aberrant cytokine signaling and STAT pathway activation

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1,105

Apexbio Technology LLC PF-543 Citrate 1415562-83-2 200mg

PF-543 Citrate (CAS 1415562-83-2) is a cell-permeable small molecule that functions as a potent and selective inhibitor of sphingosine kinase 1 (SphK1) It acts by competitively inhibiting sphingosine binding exhibiting a K(i) of 3 6 nM for SphK1 and demonstrating over 100-fold selectivity compared to the SphK2 isoform PF-543 Citrate is utilized in research to elucidate the specific contributions of SphK1-mediated sphingosine-1-phosphate (S1P) signaling in cellular and physiological processes

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1,106

Medchemexpress LLC AT9283 | 896466-04-9 | 99.7% | C19H23N7O2 | 200 MG

AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I), and Flt3 (IC50s 1-30 nM). It has been shown to inhibit the growth and survival of various solid tumors both in vitro and in vivo. This product is intended for research use only.

Potent multi-targeted kinase inhibitor
Active against Aurora A/B, JAK2/3, Abl (T315I), and Flt3
Inhibits growth and survival of various solid tumors
Induces polyploid phenotype and apoptosis in certain cancer cell lines
Shows significant tumor growth inhibition in xenograft models
Enhances survival in mouse xenograft models of mantle cell lymphoma

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1,107

Medchemexpress LLC B7-H2/ICOSLG Mouse 100ug

B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag

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1,108

Medchemexpress LLC Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl) | 188968-51-6 | 99.8% | 588.66 | 200 MG

Cilengitide (HY-16141) is a blood-brain barrier-permeable integrin antagonist. It inhibits the binding of ανβ3 and ανβ5 to Vitronectin and also inhibits TGF-β/Smad signaling, mediating PD-L1 expression. Cilengitide induces apoptosis and exhibits an antiangiogenic effect in research against glioblastoma and other cancers.

BΒB-permeable integrin antagonist.
Inhibits binding to Vitronectin.
Inhibits TGF-β/Smad signaling.
Mediates PD-L1 expression.
Induces apoptosis.
Shows antiangiogenic effect.

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1,109

Medchemexpress LLC Canagliflozin | 842133-18-0 | MFCD18251436 | 99.7% | 444.52 | C24H25FO5S | 200 MG

Canagliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor provided as a research-grade powder for biochemical and pharmacological studies. It exhibits low-nanomolar potency against SGLT2 and is used in in vitro and in vivo experiments to investigate glucose transport and metabolic pathways.

Selective SGLT2 inhibitor with low-nanomolar IC50 values.
High purity suitable for analytical and research use (≈99.7% LCMS).
Solid powder form for flexible formulation and dosing.
Stable under recommended storage conditions (powder: -20°C and 4°C).
Molecular weight 444.52 and formula C24H25FO5S.

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1,110

Apexbio Technology LLC Refametinib 923032-37-5 200mg

Refametinib (CAS 923032-37-5) is an orally bioavailable selective allosteric inhibitor of mitogen-activated protein kinase kinases MEK1 and MEK2 It binds to an allosteric site distinct from the ATP-binding pocket thereby inhibiting MEK1 and MEK2 enzymatic activity (IC50 19 nM and 47 nM respectively) and blocking phosphorylation of ERK without interfering with ATP binding Refametinib demonstrates potent inhibition in human tumor cell lines with EC50 values ranging from 2 5 to 15 8 nM and suppresses proliferation in BRAF V600E-mutant lines (GI50 67 89 nM) It induces tumor growth delay and regression in xenograft models supporting its utility in cancer research

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Quinolines and derivatives

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Medchemexpress LLC 7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AT9283 | 896466-04-9 | 99.7% | C19H23N7O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC B7-H2/ICOSLG Mouse 100ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl) | 188968-51-6 | 99.8% | 588.66 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Canagliflozin | 842133-18-0 | MFCD18251436 | 99.7% | 444.52 | C24H25FO5S | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More