Quinolines and derivatives

Medchemexpress LLC Deferoxamine (mesylate) | 138-14-7 | 99.8% | 20 MG

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Deferoxamine mesylate is an iron chelator that binds to Fe(III) and other metal cations. It is widely used to reduce iron accumulation and deposition in tissues. This compound upregulates HIF-1α levels with good antioxidant activity, shows anti-proliferative activity, and can induce apoptosis and autophagy in cancer cells. It is applicable in studies of diabetes, neurodegenerative diseases, anti-cancer research, and anti-COVID-19 research.

• Binds to Fe(III) and other metal cations
• Reduces iron accumulation and deposition in tissues
• Upregulates HIF-1α levels
• Exhibits good antioxidant activity
• Shows anti-proliferative activity
• Induces apoptosis and autophagy in cancer cells
• Applicable in studies related to diabetes, neurodegenerative diseases, anti-cancer research, and anti-COVID-19 research

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Medchemexpress LLC Deferoxamine mesylate (standard) | 138-14-7 | 99.47% | 50 MG

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Deferoxamine mesylate (Standard) is an analytical standard intended for research and analytical applications. It functions as an iron chelator, binding to Fe(III) and other metal cations, thereby reducing iron accumulation and deposition in tissues. This compound also upregulates HIF-1α levels and exhibits good antioxidant activity, along with anti-proliferative activity that can induce apoptosis and autophagy in cancer cells.

• Used in studies related to diabetes, neurodegenerative diseases, anti-cancer research, and anti-COVID-19 research
• Serves as a reference standard for assays
• Frequently utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS

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Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | MFCD09970504 | 99.9% | 564.65 | C29H32N4O6S | 5 MG

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Ruboxistaurin mesylate is an orally active, ATP-competitive, and selective protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal/eye disorders, and cardiovascular disease. It is supplied as a solid with high reported purity and is soluble in DMSO for in vitro applications.

• Selective PKCβ inhibitor with low-nanomolar potency.
• Orally active small molecule suitable for in vitro and in vivo studies.
• High reported purity (~99.9%) for research applications.
• Solid form, orange to red color, easy handling and storage.
• Soluble in DMSO at 50 MG/ML (88.55 mM); ultrasonic assistance may be required.
• Storage guidance: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).

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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.9% | 50 MG

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Danofloxacin mesylate is a fluoroquinolone used as a veterinary drug. It exhibits a broad spectrum of bactericidal activity, primarily by inhibiting the DNA cycloenzyme of bacteria. Additionally, it acts as a substrate for ATP-dependent efflux transporters (P-gp and MRP2).

• Used as a veterinary drug
• Exhibits a broad spectrum of bactericidal activity
• Primarily inhibits bacterial DNA cycloenzyme
• Acts as a substrate for ATP-dependent efflux transporters (P-gp and MRP2)

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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG

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Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid for the research of migraines. It reduces cell survival in A549 and NCI-H226 cells and inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.

• Reduces cell survival in A549 and NCI-H226 cells
• Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells
• Induces mitochondrial morphologic alterations and dysfunction
• Increases ROS generation and induces apoptosis
• Disturbs ATP production in A549 cells
• Inhibits STAT3 activation and enhances protein stability of Mcl-1

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Medchemexpress LLC Ergi-USU-6 mesylate | 2756327-67-8 | 95.0% | C14H18N4O4S | 10MG

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ERGi-USU-6 mesylate is a research-grade small-molecule inhibitor of ERG and RIOK2 with reported cellular potency (IC50 ≈ 0.13-0.17 μM in VCaP cells). The methanesulfonate salt is supplied as a solid with a reported purity of 95% and is intended for in vitro and preclinical research use.

• Inhibits ERG and RIOK2 with submicromolar cellular potency.
• Demonstrates antiproliferative activity in ERG-positive prostate cancer models.
• Supplied as a mesylate salt for improved handling and stability.
• High reported purity suitable for biochemical and cell-based assays.
• Solid form with defined cold-storage recommendations for sample integrity.

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Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | 99.9% | 564.65 g/mol | C29H32N4O6S | 50 MG

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Ruboxistaurin mesylate is an orally active, selective, ATP-competitive protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal disorders, and cardiovascular conditions. Supplied as the mesylate salt, it is an orange-to-red solid with molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.

• Selective PKCβ inhibition with low nanomolar potency (IC50 ~4.7-5.9 nM).
• Mesylate salt form for improved stability and handling.
• High purity (99.87%) suitable for research applications.
• Orange-to-red solid, convenient for solid-state storage.
• Molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.

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TARGETMOL CHEMICALS INC DABRAFENIB MESYLATE 100MG

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Also available in 5 mg 10 mg 25 mg 50 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf respectively). purity: 99%

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