Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels, intended for research use only. It also potently and selectively blocks Kir3.1-Kir3.4 channels and calcium-activated large conductance potassium channels, blocking somatostatin (SS-14)-activated current. As a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker, Tertiapin-Q significantly prolongs the atrial effective refractory period (AERP).
- Highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels
- Potently and selectively blocks Kir3.1-Kir3.4 and calcium-activated large conductance potassium channels
- Blocks somatostatin (SS-14)-activated current
- Functions as a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker
- Prolongs atrial effective refractory period (AERP)