Quinolines and derivatives
Medchemexpress LLC Pyrimethanil | 53112-28-0 | 99.9% | 200 MG
Pyrimethanil is an anilinopyrimidine and a broad-spectrum contact fungicide. It is used to control Botrytis species on various crops by inhibiting methionine biosynthesis in Botrytis cinerea. This compound is suitable for research aimed at preventing fungal diseases in fruit, vegetable, and ornamental plants with mold infections.
- Inhibits methionine and other amino acids biosynthesis in Botrytis cinerea.
- Aids research into preventing fungal diseases on fruit, vegetable, and ornamental plants.
- Decreases polygalacturonase, cellulase, proteinase, and laccase activities.
- Molecular weight: 199.25.
- Molecular formula: C12H13N3.
- Appearance: White to off-white solid.
Chemscene ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
eMolecules Ambeed 3 4-Dimethoxy-2-nitrobenzoic acid 100mg 525226340 A578526 0 000 79025-28-8 MFCD00074884 227 172 C9H9NO6
Ambeed 3 4-Dimethoxy-2-nitrobenzoic acid 100mg 525226340 A578526 0 000 79025-28-8 MFCD00074884 227 172 C9H9NO6
Apexbio Technology LLC GNF-5837 1033769-28-6 200mg
GNF-5837 (CAS 1033769-28-6) is a potent and selective pan-Trk inhibitor exhibiting inhibitory activity against TrkA and TrkB with IC50 values of 8 nM and 12 nM respectively In cellular assays GNF-5837 suppresses proliferation in TRKA/NGF-expressing Ba/F3 and RIE cells with IC50 values of 0 042 M and 0 017 M respectively The compound has also been shown to inhibit c-Kit and PDGFR in select cell models In vivo GNF-5837 demonstrated dose-dependent tumor inhibition in xenograft mouse models derived from TRKA/NGF-expressing RIE cells Its oral bioavailability and specificity make it a valuable tool for investigating TRK signaling in oncogenic processes and other disease models No clinical evaluation has been reported to date
Apexbio Technology LLC AZD1208 1204144-28-4 200mg
AZD1208 (CAS 1204144-28-4) is a selective orally bioavailable pan-Pim kinase inhibitor targeting Pim-1 Pim-2 and Pim-3 kinases with IC50 values of 0 4 nM 5 nM and 1 9 nM respectively Pim kinases are implicated in proliferative and anti-apoptotic signaling downstream of cytokines and growth factors frequently overexpressed in leukemia and lymphoma In vitro AZD1208 inhibits growth induces cell cycle arrest apoptosis and reduces phosphorylation of the anti-apoptotic protein Bcl-2 in AML cell lines Preclinically this compound suppresses tumor growth in AML xenograft models supporting its current clinical evaluation in AML and solid tumor trials
Apexbio Technology LLC Rimantadine 13392-28-4 200mg
Rimantadine (13392-28-4) is a small-molecule inhibitor targeting the M2 ion channel protein of influenza A virus It is designed to specifically block the M2 channel thereby inhibiting the viral uncoating process and preventing subsequent viral entry into host cells Rimantadine exerts its biological activity primarily through inhibition of the M2 ion channel In in vitro studies rimantadine demonstrates antiviral activity with reported IC50 values typically ranging from approximately 0 1 to 1 M depending on virus strain and experimental context Based on these pharmacological properties rimantadine holds research potential in investigating influenza A viral replication resistance mutations infection pathways and in evaluating antiviral activity and establishing infection models in vitro