Quinolines and derivatives
Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.79% | 1 ML
Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It enhances gastric contractility and accelerates delayed gastric emptying, making it a potential research compound for functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Enhances gastric contractility and accelerates delayed gastric emptying.
- Reduces expression levels of IκB-α phosphorylation in stimulated macrophage cell lines.
- Significantly reduces TNF-α and IL-6 productions in stimulated NR8383 cells.
- Increases postprandial gastric motility index in a dose-dependent manner in vivo.
- Improves functional dyspepsia by inhibiting AChE.
Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 500 MG
Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase inhibitor, with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. This compound has potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Acts as an orally active, selective, and reversible acetylcholinesterase inhibitor.
- Enhances gastric contractility.
- Accelerates delayed gastric emptying.
- Has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammation.
Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G
Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. It has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor
- Enhances gastric contractility and accelerates delayed gastric emptying
- Potential for research of functional dyspepsia and intestinal inflammatory conditions
eMolecules 5-hydroxyquinoline-2-carbonitrile | 586413-05-0 | MFCD18415939 | 1g
Pharmablock | 5-hydroxyquinoline-2-carbonitrile | 1g | 551208196 | PB05701 | | 586413-05-0 | MFCD18415939 | 170.171 | C10H6N2O
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Medchemexpress LLC Sevabertinib (BAY 2927088) | 2521285-05-0 | 99.9% | 484.93 | 200 MG
Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor with potent anticancer activity against lung cancer. It shows significantly reduced activity against HER4.
- Orally active and reversible dual EGFR-HER2 inhibitor
- Exhibits anticancer activity against lung cancer
- Potently inhibits proliferation of isogenic Ba/F3 cells ectopically expressing HER2 exon 20 insertions
- Potently inhibits proliferation of isogenic Ba/F3 cells activating HER2 point mutations or putative secondary acquired resistance mutations
- Inhibits proliferation of lung cancer cell lines NCI-H1781 and NCI-H2170