Quinolines and derivatives
Medchemexpress LLC PH-797804 | 586379-66-0 | 98.9% | 477.30 g·mol⁻¹ | C22H19BrF2N2O3 | 200 MG
PH-797804 is an ATP-competitive, selective inhibitor of p38 mitogen-activated protein kinases (p38α/p38β) used in research to probe p38-mediated signaling and inflammatory responses. It shows nanomolar biochemical potency and demonstrable cellular activity that reduces LPS-induced cytokine production.
- Selective ATP-competitive p38α/p38β inhibitor.
- Nanomolar biochemical potency (p38α IC50 26 nM; Ki 5.8 nM).
- Demonstrated cellular activity reducing LPS-induced TNF-α and IL-1β release.
- Does not inhibit JNK2, supporting target selectivity.
- High supplied purity and solid white to off-white appearance.
- Suitable for biochemical and cellular assay applications.
Selleck Chemical LLC Chelerythrine Chloride (NSC 646662) S1292-5mg
Chelerythrine Chloride (NSC 646662 Broussonpapyrine) is a potent selective antagonist of PKC with IC50 of 0 66 M
Selleck Chemical LLC Chelerythrine Chloride (NSC 646662) S1292-25mg
Chelerythrine Chloride (NSC 646662 Broussonpapyrine) is a potent selective antagonist of PKC with IC50 of 0 66 M
Selleck Chemical LLC Chelerythrine-E0124-25MG
Chelerythrine (Toddaline Broussonpapyrine) is a potent selective antagonist of PKC with an IC50 of 0 66 M Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1 5 M Chelerythrine shows antitumor antidiabetic and anti-inflammatory activity
Apexbio Technology LLC Chelerythrine Chloride 3895-92-9 5mg
Chelerythrine Chloride (CAS 3895-92-9) is a benzophenanthridine alkaloid widely utilized as a selective antagonist of protein kinase C (PKC) with an IC50 of 0 66 M It acts as a high-specificity inhibitor by targeting the kinase regulatory domain serving as a competitive inhibitor with respect to phosphate receptors and a non-competitive inhibitor toward ATP Chelerythrine also inhibits Bcl-xL inducing apoptosis in mouse embryonic fibroblasts (MEFs) with an IC50 of 1 1 M It activates the JNK1 and p38 pathways via MEKK1 and MKK4 contributing to its pro-apoptotic effects In cellular assays chelerythrine reduces cell viability (MTT IC50 2 6 M) and in animal studies promotes apoptosis through reactive oxygen species generation Its applications extend to research on kinase activity apoptosis antimicrobial activity and anti-inflammatory processes
Apexbio Technology LLC Chelerythrine Chloride 3895-92-9 10mM (in 1mL DMSO)
Chelerythrine Chloride (CAS 3895-92-9) is a benzophenanthridine alkaloid widely utilized as a selective antagonist of protein kinase C (PKC) with an IC50 of 0 66 M It acts as a high-specificity inhibitor by targeting the kinase regulatory domain serving as a competitive inhibitor with respect to phosphate receptors and a non-competitive inhibitor toward ATP Chelerythrine also inhibits Bcl-xL inducing apoptosis in mouse embryonic fibroblasts (MEFs) with an IC50 of 1 1 M It activates the JNK1 and p38 pathways via MEKK1 and MKK4 contributing to its pro-apoptotic effects In cellular assays chelerythrine reduces cell viability (MTT IC50 2 6 M) and in animal studies promotes apoptosis through reactive oxygen species generation Its applications extend to research on kinase activity apoptosis antimicrobial activity and anti-inflammatory processes