Quinolines and derivatives
Apexbio Technology LLC Temsirolimus 162635-04-3 200mg
Temsirolimus (CCI-779) is an ester analog of rapamycin functioning as an inhibitor of the mammalian target of rapamycin (mTOR) The compound suppresses mTOR signaling pathways thus inhibiting cellular proliferation and growth In preclinical studies on breast cancer cell lines Temsirolimus displayed inhibitory activities with reported IC50 values of 0 6 nM in BT-474 cells 0 7 nM in MDA-MB-468 and SKBR-3 cells and 50 nM in MCF-7 cells It has been examined in xenograft models of tumors with PTEN mutations and multiple myeloma for investigating pathways related to cell-cycle progression and proliferation regulated by mTOR
Medchemexpress LLC Temsirolimus | 162635-04-3 | C56H87NO16 | 200MG
Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. It activates autophagy and prevents deterioration of cardiac function in animal models. This product is an analytical standard intended for research and analytical applications.
- Inhibits mTOR kinase activity
- Activates autophagy
- Prevents deterioration of cardiac function
- Induces apoptosis in primary human lymphoblastic leukemia (ALL) cells
- Delays growth of xenografts
- Improves performance on behavioral tasks in Huntington disease models
Medchemexpress LLC Selonsertib | 1448428-04-3 | 99.1% | 445.49 | 200 MG
Selonsertib (GS-4997) is an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3. It has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. It is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
- Orally bioavailable.
- Selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor.
- pIC50 of 8.3 for ASK1.
- Competes with ATP in the ASK1 catalytic kinase domain.
- Highly selective and potent once-daily oral ASK1 inhibitor.
- Evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
Medchemexpress LLC 7-bromoquinoline-4-carboxylic acid | 31009-04-8 | MFCD11108751 | 96.1% | 252.06 | C10H6BrNO2 | 1 G
7-Bromoquinoline-4-carboxylic acid is a brominated quinoline carboxylic acid used as an intermediate in organic synthesis and medicinal chemistry research. It is supplied as a gray to brown solid (C10H6BrNO2; MW 252.06; CAS 31009-04-8) with typical HPLC purity of 96.12%. Storage recommendations: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Used as an intermediate for organic synthesis
- Suitable for medicinal chemistry research applications
- Supplied as a stable solid with defined storage conditions
- Provided with HPLC purity data for quality assessment
- Batch certificate of analysis available for traceability
Medchemexpress LLC 7-bromoquinoline-4-carboxylic acid | 31009-04-8 | MFCD11108751 | 96.1% | 252.06 | C10H6BrNO2 | 500 MG
7-Bromoquinoline-4-carboxylic acid is an organic small-molecule reagent used primarily as an intermediate in synthetic chemistry and for biochemical assay research. It is a brominated quinoline carboxylic acid commonly employed to build substituted heterocycles and as a starting material for structure-activity studies.
- Used as an intermediate in chemical synthesis and biochemical research.
- Molecular formula C10H6BrNO2 and molecular weight 252.06 g·mol-1.
- CAS number 31009-04-8 for unambiguous identification.
- Typical purity 96.1% (HPLC) as reported on the certificate of analysis.
- Appearance: gray to brown solid.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months) or -20°C (1 month).