Tetrapyrroles and derivatives
Abcam Ciproxifan maleate, prototypic H3 inverse agonist / antagonist.
Ciproxifan maleate, prototypic H3 inverse agonist / antagonist.
The product is subject to the following: Abcam Restricted Use Statement
Abcam DPDPE, delta opioid receptor agonist, 1MG
MW 645.79 g/mol, Purity >95%. Potent and selective δ opioid receptor agonist (Ki values are 14, >1000 and >1000 nM for opioid receptor subtypes δ, κ and μ, respectively). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rotigotine hydrochloride, Dopamine receptor agonist, 10MG
MW 351.93 g/mol, Purity >99%. Dopamine receptor agonist. High affinity for D₁, D₂ and D₃ receptors (Ki values are 83, 13 and 0.71 nM, respectively). Shows significant affinity at α₂B and 5-HT₁A receptors (Ki values are 27 and 30 nM, respectively). Exhibits anti-Parkinsonian and antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Flupenthi x ol dihydrochloride, Non-selective dopamine receptor antagonist, 50MG
MW 507.4 Da, Purity >99%. Non-selective antagonist at D₁ and D₂ receptors. Antagonist at dopamine (D₁-D₅), serotonin (5-HT₂), adrenergic (α₁) and histamine (H₁) receptors. Antipsychotic properties in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors, 50MG
MW 311.72 Da, Purity >99%. Competitive, type II positive allosteric modulator for α7nAChR (EC₅₀ = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (S)-(-)-Raclopride, D2 receptor antagonist, 10MG
MW 347.24 g/mol, Purity >97%. High affinity (Kd = 1.2 nM) and high selectivity for D₂ receptors in vitro and in vivo (IC₅₀ = 32 nM). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-277011-A dihydrochloride, D3 antagonist, 5MG
MW 511.5 Da, Purity >98%. Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (R,S)-CPP, NMDA antagonist, 10MG
MW 252.2 Da. Potent, competitive NMDA antagonist. See separate isomer (ab120159). Also available in simple stock solutions (ab146720) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ibotenic acid, e x citoto x ic agonist, 1MG
MW 158.11 Da, Purity >98%. Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GS 39783, GABAB positive allosteric modulator, 10MG
MW 337.4 Da, Purity >99%. Novel, GABAB positive allosteric modulator (EC50 = 3 μM for [35S]GTPγS binding). Shows anxiolytic and antiaddictive effects *in vivo.* Blood-brain barrier permeable*.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist, 1MG
MW 1084.2 Da, Purity >95%. (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences Protoporphyrin IX (free acid) (300mg). CAS: 553-12-8
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable. Alternative name: 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid. Purity: ≥95% (HPLC). Solubility: Dissolve initially in 0.1M base (Tris base or NaOH), then add water miscible organic solvent (EtOH (10mg/ml), MeOH, DMSO (10mg/ml), DMF) until solution is 50/50 base/solvent. When a clear solution is obtained, it can be diluted into an aqueous medium and titrated or buffered to any pH>7. Use immediately. Long Term Storage: -20°C.
Cayman Chemical CobaltIc III ProtoporphyrIn
An inhibitor of mucin synthesis inhibits glucosamine labeling in Caco-2 HT-29 and T84 colon cancer cells at 2 mM enhances 5-fluorouracil-induced cell death in Capan-1 and HPAF-II cells at 0.4 0.6 and 0.8 mg/ml LS 174T colon cancer cells grown in the presence of benzyl-a-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells
Sigma Aldrich Fine Chemicals Biosciences CopperII phthalocyanine su5G
Copper(II) phthalocynaine (CuPc) is a metal phthalocyanine dye that acts as a p-type semiconductor. It has a charge mobility of 10-4 cm2/Vs. It forms a chemically stable thin film that exhibits photoconductivity and catalytic activity.
Cayman Chemical ZInc ProtoporphyrIn-9 25mg
A cell-permeant inhibitor of CK1 (IC50 200 nM from S. pombe 300 nM for CK1) only weakly affects the activities of a panel of kinases tested