Tetrapyrroles and derivatives
Sigma Aldrich Fine Chemicals Biosciences Methylcobalamin vitamin B125MG
Methylcobalamin (MeCbl) is an analog of vitamin B12 (cobalamin). It differs from cobalamin by containing a methyl group. The physiologically active form of vitamin B12 include methylcobalamin and adenosylcobalamin.
Medchemexpress LLC Biliverdin | 114-25-0 | MFCD00870216 | 70.0% | 582.65 | C33H34N4O6 | 5 MG
Biliverdin is a tetrapyrrolic bile pigment produced during heme catabolism and provided as a research reagent for biochemical and cellular studies. It is investigated for antioxidant, anti-inflammatory, and immunomodulatory effects and for its role in heme metabolism and tissue protection. For research use only.
- Endogenous metabolite used in biochemical and cell biology research.
- Exhibits antioxidant, anti-inflammatory, and immunosuppressant properties.
- Soluble in DMSO at about 3 mg/mL; ultrasonic warming recommended.
- Store at -20°C protected from light; in solvent store at -80°C for long-term stability.
- Available in small milligram quantities suitable for laboratory experiments.
Medchemexpress LLC Bilirubin oxidase (BOD) | 80619-01-8 | ≥10 U/mg solid | 1000 U
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. It participates in the metabolism of porphyrin and chlorophyll. It is widely used in biochemical research as a catalyst for oxygen reduction.
- Catalyzes oxidation of bilirubin to biliverdin
- Reduces molecular oxygen to water
- Participates in metabolism of porphyrin and chlorophyll
- Used as a catalyst for oxygen reduction in biochemical research
Medchemexpress LLC Biliverdin hydrochloride | 856699-18-8 | MFCD06245593 | 99.3% | 619.11 g/mol | C33H35ClN4O6 | 5 MG
Biliverdin hydrochloride is a water-soluble tetrapyrrolic bile pigment produced during heme catabolism. Supplied as a green to dark-green solid, it is used as a biochemical reagent in studies of heme metabolism, oxidative stress, and inflammation. Analytical identifiers include CAS 856699-18-8, formula C33H35ClN4O6, and molecular weight 619.11 g/mol.
- High purity (99.3%) suitable for in vitro biochemical applications.
- Available in small research pack sizes, including 5 mg, for assay development.
- Soluble in DMSO (20 mg/mL) with warming or sonication; low water solubility.
- Store sealed, away from moisture; stable at -20°C, with longer stability at -80°C in solution.
- Green to dark green solid allowing easy visual confirmation of material.
Cayman Chemical MethylcobalamIn 250mg
An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer
Selleck Chemical LLC Protoporphyrin IX (PPIX) S5145-1g
Protoporphyrin IX (PPIX) is a heterocyclic organic compound which consists of four pyrrole rings and is the final intermediate in the heme biosynthetic pathway
Abcam EMD 386088 hydrochloride, 5-HT6 agonist, 50MG
MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168077 maleate, D4 agonist, 10MG
MW 450.49 g/mol, Purity >98%. Potent, selective D₄ dopamine receptor agonist. Displays >400-fold selectivity over D₂ and >300-fold selectivity over D₃ subtypes (Ki values are 11.9, 2540, and 1050 nM for D₄, D₃, and D₂ receptors, respectively). Reverses object recognition deficits.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors, 50MG
MW 311.72 Da, Purity >99%. Competitive, type II positive allosteric modulator for α7nAChR (EC₅₀ = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Prodigiosin, apoptotic agent, 1MG
MW 323.4 Da, Purity >95%. Potent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pancuronium dibromide, Competitive nicotinic acetylcholine receptor antagonist, 250MG
MW 732.7 Da. Competitive nicotinic acetylcholine receptor (nAChR) antagonist. Displaces acetylcholine (ab120469) from nAChRs (IC₅₀ = 5.5 nM). Neuromuscular blocker and muscle relaxant.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ZInc ProtoporphyrIn-9 25mg
A competitive inhibitor of heme oxygenase that also inhibits soluble guanylyl cyclase and inactivates the NOS isoforms nNOS, iNOS, and eNOS (IC50s = 0.8, 4, and 5 μM, respectively); used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia