Thienothiazines
Brinzolamide 98.0+%, TCI America™
CAS: 138890-62-7 Molecular Formula: C12H21N3O5S3 Molecular Weight (g/mol): 383.496 MDL Number: MFCD08067749 InChI Key: HCRKCZRJWPKOAR-JTQLQIEISA-N Synonym: (R)-4-(Ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide PubChem CID: 68844 ChEBI: CHEBI:41212 IUPAC Name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide SMILES: CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
Lornoxicam 98.0+%, TCI America™
CAS: 70374-39-9 Molecular Formula: C13H10ClN3O4S2 Molecular Weight (g/mol): 371.81 MDL Number: MFCD00866163 InChI Key: WLHQHAUOOXYABV-UHFFFAOYSA-N Synonym: 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide PubChem CID: 54690031 ChEBI: CHEBI:31783 IUPAC Name: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide SMILES: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
![(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide 98.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-160982-16-1.jpg-250.jpg)
(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide 98.0+%, TCI America™
CAS: 160982-16-1 Molecular Formula: C6H6ClNO3S2 Molecular Weight (g/mol): 239.688 MDL Number: MFCD09033311 InChI Key: OFJGKGNJDCLNPM-SCSAIBSYSA-N PubChem CID: 11746721 IUPAC Name: (4S)-6-chloro-1,1-dioxo-3,4-dihydro-2H-thieno[3,2-e]thiazin-4-ol SMILES: C1C(C2=C(SC(=C2)Cl)S(=O)(=O)N1)O
![Medchemexpress LLC 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl- | 70374-39-9 | >99.3% | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl- | 70374-39-9 | >99.3% | 500 MG
2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl- | 70374-39-9 | >99.3% | 500 MG
Medchemexpress LLC Methyl 5-chloro-3-(N-methylsulfamoyl)thiophene-2-carboxylate | 70374-37-7 | MFCD09839764 | 100mg
Lornoxicam impurity 16 is an impurity of Lornoxicam (HY-B0367)
Medchemexpress LLC Lornoxicam impurity 16 | 70374-37-7 | MFCD09839764 | 50mg
Lornoxicam impurity 16 is an impurity of Lornoxicam (HY-B0367)
Cayman Chemical BrInzolamIde 100mg
A potent carbonic anhydrase inhibitor (IC50s = 3.19 and 45.3 nM for CAII and CAIV, respectively); selective for CAII and CAIV over CAI (IC50 = ~1,365 nM); reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice at 30 mg/kg; topical administration reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension at 0.25, 0.5, and 1 mg/eye; reduces IOP in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension
Cayman Chemical BrInzolamIde 10mg
A potent carbonic anhydrase inhibitor (IC50s = 3.19 and 45.3 nM for CAII and CAIV, respectively); selective for CAII and CAIV over CAI (IC50 = ~1,365 nM); reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice at 30 mg/kg; topical administration reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension at 0.25, 0.5, and 1 mg/eye; reduces IOP in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension
Sigma Aldrich Fine Chemicals Biosciences Brinzolamide >=98% (HPLC) | 138890-62-7 | MFCD08067749 | 10MG
Brinzolamide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 383.51 | 138890-62-7 | MFCD08067749 | 10MG
Apexbio Technology LLC Brinzolamide 138890-62-7 10mM (in 1mL DMSO)
Brinzolamide (CAS 138890-62-7) is a potent and selective inhibitor of carbonic anhydrase II (CA II) with an IC50 of 3 19 nM and a Ki of 0 13 nM in vitro By inhibiting CA II brinzolamide disrupts the reversible hydration of carbon dioxide thereby reducing aqueous humor production and lowering intraocular pressure Demonstrated to have higher affinity and inhibitory efficacy for CA II compared to CA I and CA IV brinzolamide has been shown to significantly decrease intraocular pressure in animal models Additionally it is utilized in research settings to assess cerebral blood flow reserve as CA inhibition modulates tissue CO2 levels and consequent vasodilation
Sigma Aldrich Fine Chemicals Biosciences Brinzolamide >=98% (HPLC) | 138890-62-7 | MFCD08067749 | 50MG
Brinzolamide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 383.51 | 138890-62-7 | MFCD08067749 | 50MG
Medchemexpress LLC Brinzolamide | 138890-62-7 | 99.9% | 5 MG
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. This compound reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion, making it suitable for glaucoma disease research.
- Selective carbonic anhydrase II inhibitor
- Reduces intraocular pressure (IOP)
- Inhibits ciliary CA-II and decreases atrial fluid secretion
- Suitable for glaucoma disease research
Medchemexpress LLC Brinzolamide | 138890-62-7 | 99.91% | 1 ML
Brinzolamide (AL-4862) is a highly selective carbonic anhydrase II inhibitor, demonstrating an IC50 value of 3.2 nM. It functions by reducing intraocular pressure through the inhibition of ciliary CA-II, thereby decreasing atrial fluid secretion. This compound is utilized in the topical treatment of elevated intraocular pressure in individuals diagnosed with ocular hypertension or open-angle glaucoma.
- Selective carbonic anhydrase II inhibitor
- IC50 value of 3.2 nM
- Reduces intraocular pressure
- Inhibits ciliary CA-II
- Decreases atrial fluid secretion
- Used for ocular hypertension
- Used for open-angle glaucoma
Medchemexpress LLC Lornoxicam | 70374-39-9 | 98.7% | 1 ML
Lornoxicam is an orally active nonsteroidal anti-inflammatory drug (NSAID) that demonstrates analgesic, anti-inflammatory, antipyretic, and anticancer properties. It effectively inhibits both COX-1 and COX-2, as well as the production of NO by iNOS and the proinflammatory cytokine IL-6. This compound also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis, making it suitable for research into inflammatory pain, colorectal cancer, and breast cancer.
- Orally active nonsteroidal anti-inflammatory drug (NSAID)
- Exhibits analgesic, anti-inflammatory, antipyretic, and anticancer activities
- Effectively inhibits COX-1 and COX-2
- Inhibits NO production by iNOS
- Inhibits proinflammatory cytokine IL-6
- Inhibits tumor cell proliferation and migration
- Induces tumor cell apoptosis
- Useful in inflammatory pain, colorectal cancer, and breast cancer studies
Medchemexpress LLC Brinzolamide | 138890-62-7 | 99.9% | 100 MG
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. It reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion, and can be used in glaucoma disease research.
- Selective carbonic anhydrase II inhibitor
- IC50 value of 3.2 nM
- Reduces intraocular pressure (IOP)
- Suitable for glaucoma disease research
- Molecular weight: 383.51
- Molecular formula: C12H21N3O5S3
- Appears as a solid, light yellow to yellow