Carboximidamides
eMolecules Medchem Express / AN0128 / 5mg / 705860157 / HY-10979 / / 872044-70-7 / MFCD18251581 / 400.060 / C20H16BCl2NO3
Medchem Express / AN0128 / 5mg / 705860157 / HY-10979 / / 872044-70-7 / MFCD18251581 / 400.060 / C20H16BCl2NO3
Medchemexpress LLC 1H-1,2,3-triazole-4-carboxamide derivative (BIIB091) | 2247614-80-6 | 99.9% | C28H34N10O2 | 10MG
BIIB091 is a potent, selective, reversible Bruton's tyrosine kinase (BTK) inhibitor supplied as a high-purity small-molecule reagent for research and preclinical studies. It is used to probe BTK signaling and to evaluate therapeutic approaches in autoimmune and B-cell-mediated disease models. Not for human or clinical use.
- Potent, selective reversible BTK inhibitor (IC50 <0.5 nM).
- High purity (99.85% by HPLC).
- Molecular formula C28H34N10O2; molecular weight 542.64.
- Suitable for in vitro and preclinical assays.
- Orally active profile reported in preclinical studies.
- Supplied as a powder; soluble in DMSO.
Medchemexpress LLC Melagatran | 159776-70-2 | 99.3% | 1 MG
Melagatran is a reversible, selective, and orally active direct inhibitor of thrombin, with a Ki of 2 nM. It functions by binding directly to the active site of thrombin, inhibiting the conversion of fibrinogen to fibrin. This compound also reduces the DNA binding activity of NF-κB and AP-1, making it relevant for research in cardiovascular diseases and ischemic brain damage. It has been shown to alleviate ischemic brain damage and decrease the size of advanced atherosclerotic lesions.
- Targets thrombin with a Ki of 2 nM.
- Alleviates endotoxin-induced systemic hemodynamic disorders.
- Prevents or delays electrically induced occlusive thrombus formation.
- Demonstrates good oral bioavailability.
- Reduces ischemic brain injury in rats.
- Reduces advanced atherosclerotic lesion size and promotes plaque stability.
- Decreases DNA binding activity of NF-κB and AP-1.
Medchemexpress LLC Creatine kinase M-type (CKM) protein, human (N-His tag) | 9001-15-4 | >95.0% | 10 UG
Recombinant human creatine kinase M-type (CKM) protein with an N-terminal His tag, expressed in E. coli and supplied as a purified, biologically active enzyme for research use. The protein is approximately 45 kDa, available in microgram quantities, and characterized for activity and purity (>95% by reducing SDS-PAGE). Intended for biochemical assays, enzyme activity studies, and antibody validation; not for clinical or diagnostic use.
- Recombinant human CKM with N-terminal His tag.
- Expressed in E. coli for high-yield production.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Biologically active and suitable for enzymatic assays.
- Supplied in microgram quantities for small-scale experiments.
- Datasheet and COA provided for lot-specific quality information.
Medchemexpress LLC Allantoin (Standard) | 97-59-6 | MFCD00005260 | 158.12 | 25 MG
Allantoin (Standard) is the analytical standard of Allantoin, intended for research and analytical applications. It acts as a skin conditioning agent, promoting healthy skin and stimulating new, healthy tissue growth. This compound is typically used as an analytical standard for assays and in qualitative, quantitative, and methodological research experiments.
- Promotes healthy skin
- Stimulates new and healthy tissue growth
- Used in HPLC, GC, and MS research experiments
- Reference for assays
Medchemexpress LLC 1-tert-butyl N-(5R)-substituted triazole-4-carboxamide (BIIB091) | 2247614-80-6 | 99.9% | 542.64 g/mol | C28H34N10O2 | 5 MG
BIIB091 is a potent, selective, orally active, reversible Bruton tyrosine kinase (BTK) inhibitor supplied for laboratory research. It shows sub-nanomolar enzymatic potency and is provided as solid material or as a DMSO solution for in vitro and preclinical studies; refer to the manufacturer datasheet for safety, handling, and the certificate of analysis.
- Sub-nanomolar BTK potency (IC50 <0.5 nM).
- Reversible and highly selective BTK inhibition.
- Chemical formula C28H34N10O2; molecular weight 542.64 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (>99.8% by HPLC) suitable for research applications.
eMolecules AstaTech / 2-AMINO-4-(4-PYRIDINYL)-PYRIMIDINE / 0.25g / 721753963 / 31098 / 97.000 / 66521-70-8 / MFCD03305477 / 172.191 / C9H8N4
AstaTech / 2-AMINO-4-(4-PYRIDINYL)-PYRIMIDINE / 0.25g / 721753963 / 31098 / 97.000 / 66521-70-8 / MFCD03305477 / 172.191 / C9H8N4
TARGETMOL CHEMICALS INC N-p-Tosyl-GPR-pNA acetate 25MG
Also available in 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.
Medchemexpress LLC PDE12-IN-1 | 2259620-80-7 | 98.9% | 616.48 | C31H27BrFN5O3 | 10 MG
PDE12-IN-1 is a selective phosphodiesterase 12 (PDE12) inhibitor provided for laboratory research use. It shows potent enzyme inhibition and modulates 2′,5′-linked adenylate polymer levels in cellular assays. Intended for in vitro biochemical and cell-based studies; not for human or clinical use.
- Selective PDE12 inhibition with reported pIC50 ≈ 9.1.
- Suitable for biochemical and cellular assays.
- High purity: 98.9%.
- Available in small pack sizes for screening and optimization.
- Molecular formula C31H27BrFN5O3; molecular weight 616.48.
Cambridge Isotope Laboratories Clonidine (unlabeled) 100 mg/mL in methanol 1 2 mL
Clonidine (unlabeled) 100 mg/mL in methanol 1 2 mL
Medchemexpress LLC AN0128 | 872044-70-7 | 98.95% | 400.06 | 10 MG
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. It has demonstrated efficacy against *S. aureus*, *S. epidermidis*, *P. acnes*, and *B. subtilis* with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, and 1 μg/mL, respectively. This product is intended for research in periodontal and cutaneous diseases.
- Acts as an antibacterial agent.
- Functions as an anti-inflammatory agent.
- Inhibits the release of pro-inflammatory cytokines (TNF-α, IL-1β) in human peripheral blood mononuclear cells (PBMCs) at 10 μM.
- Reduces inflammatory infiltrate and bone loss in experimental periodontitis.
- Shows greater effectiveness than a common toothpaste in reducing bone loss and increasing bone volume in animal models of periodontitis.
- Available in solid form, white to off-white in color.
Sigma Aldrich Fine Chemicals Biosciences Clonidine hydrochloride solid | 4205-91-8 | MFCD00036705 | 250MG
Clonidine hydrochloride solid | Mol Wt: 266.55 | 4205-91-8 | MFCD00036705 | 250MG
Medchemexpress LLC β-cryptoxanthin ((3R)-β-cryptoxanthin) | 472-70-8 | MFCD09763658 | ≥99.0% | 552.9 g/mol | C40H56O | 1 MG
β-Cryptoxanthin is an oxygenated carotenoid (C40H56O) found in citrus fruits, red peppers, and pumpkin. It exhibits potent antioxidant activity and reported anti-stress effects, and is provided as a research-grade reagent for studies of antioxidant function, carotenoid metabolism, and nutritional biochemistry.
- Oxygenated carotenoid with antioxidant activity.
- Isolated from fruits and vegetables such as tangerines, red peppers, and pumpkin.
- Used in antioxidant assays and carotenoid biology studies.
- Available in small milligram pack sizes for research use.
- Molecular weight 552.9 g/mol; chemical formula C40H56O.
Medchemexpress LLC Boldine | 476-70-0 | 5 MG
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). It is an orally effective antioxidant, anti-inflammatory, and antitumor agent that can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT, and GSK-3β, and it ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
- Purity: 99.0%
- Appearance: Solid
- Color: Off-white to light yellow
- Molecular weight: 327.37
- Formula: C19H21NO4
- Structure classification: Alkaloids, isoquinoline alkaloids, phenols, polyphenols
- Initial source: Plants, Lauraceae, Litsea cubeba (Lour.) Pers.