Carboximidamides
Medchemexpress LLC Glycyrrhisoflavone | 116709-70-7 | 5 MG
Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase. It is intended for research use only.
- Active prenylflavonoid
- Inhibits α-glucosidase
- For research use only
- Purity of 99.43%
- Appearance is off-white to light yellow solid
- Classified as a flavonoid, isoflavone, phenol, polyphenol
- Derived from Glycyrrhiza uralensis Fisch.
- Shows cytotoxicity against human PC3 cells (IC50 62.1 μM)
- Shows cytotoxicity against african green monkey Vero cells (IC50 52.8 μM)
Medchemexpress LLC Pentagamavunon-1 | 27060-70-4 | 99.0% | 348.43 | 50 MG
Pentagamavunon-1 (PGV-1) is a Curcumin analog with oral activity. It targets several molecular mechanisms to induce apoptosis, including the inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 also inhibits NF-κB activation.
- Enhances cytotoxic effect of 5-FU on WiDr cells
- Induces G2/M arrest in WiDr cells
- Exhibits significant anti-tumor activity in a PDX model
- Suppresses tumor formation in vivo without obvious toxicity
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 10 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. It exhibits good CNS-agent like properties and clinical candidate potential. BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization. In vivo, BNC375 (0.003-10.0 mg/kg, administered orally) exhibits a Minimum Effective Dose (MED) of 0.03 mg/kg, achieving full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model. It has a plasma half-life (t1/2) of 1.2 hours.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent like properties.
- Clinical candidate potential.
- Significantly potentiates acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment in mouse T-maze model.
- Plasma half-life (t1/2) of 1.2 hours.
Medchemexpress LLC PIN1 inhibitor API-1 25mg | 680622-70-2 | 366.30 g/mol | C15H13F3N6O2 | 25 MG
PIN1 inhibitor API-1 is a small-molecule research compound that inhibits Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) and functions as a microRNA activator. Supplied as a solid with high reported purity, it is suitable for in vitro biochemical and cell-based studies and is soluble in DMSO and in certain co-solvent formulations.
Medchemexpress LLC HY-19026 5mg Medchemexpress, Siguazodan CAS:115344-47-3 Purity:>98%
Medchemexpress, HY-19026 5mg Siguazodan CAS:115344-47-3 Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | C22H25ClFN3O4S | 10MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of lysyl oxidase-like enzymes LOXL2 and LOXL3, described in the medicinal chemistry literature as a mechanism-based inhibitor with anti-fibrotic activity and high selectivity for LOXL2. It is supplied for research use and has been characterized by CAS, formula, and molecular weight in supplier and public databases.
- Irreversible mechanism-based inhibitor of LOXL2 and LOXL3.
- Greater than 300-fold selectivity for LOXL2 versus LOX.
- Reported Ki ~83 nM for LOXL2 and pIC50 ≈ 8.4.
- Suitable for anti-fibrotic and LOXL biology research.
- Characterized molecular formula and molecular weight for analytical use.
Medchemexpress LLC AN0128 | 872044-70-7 | 98.95% | 400.06 | 50 MG
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. It is effective against various bacteria including *S. aureus*, *S. epidermidis*, *P. acnes*, and *B. subtilis*. This compound can be utilized in the research of periodontal disease and cutaneous diseases, demonstrating strong inhibition of pro-inflammatory cytokines *in vitro* and reduction of inflammatory infiltrate and bone loss *in vivo*.
- Boron-containing antibacterial and anti-inflammatory agent
- Effective against *S. aureus*, *S. epidermidis*, *P. acnes*, and *B. subtilis*
- Utilized for research on periodontal disease and cutaneous diseases
- Inhibits release of pro-inflammatory cytokines (TNF-α, IL-1β) in PBMCs
- Reduces inflammatory infiltrate and bone loss *in vivo*
- Increases bone area and bone volume in experimental periodontitis rat model
- Decreases bone loss and inflammation in experimental periodontitis rat model
Selleck Chemical LLC Allantoin S3856-25mg
Allantoin (Glyoxyldiureide 5-Ureidohydantoin) produced from uric acid is a major metabolic intermediate in most organisms including animals plants and bacteria
Chem-Impex International, Inc. Biuret | 108-19-0 | MFCD00007946 | 25G
Biuret, 108-19-0, MFCD00007946, 25G
AdipoGen Bis4methylphenyliodonium PF6
Chemical. CAS 60565-88-0. Formula C14H14F6IP. MW 454.13. Synthetic. Building block for synthesis. Reagent used for electrophilic phenylation, e.g. of malonates and dithiocarboxylates.
Selleck Chemical LLC Rhosin hydrochloride 10mM 1mL in DMSOPurity 99.99
Rhosin hydrochloride 10mM 1mL in DMSOPurity 99.99
Sigma Aldrich Fine Chemicals Biosciences Clonidine hydrochloride solid | 4205-91-8 | MFCD00036705 | 250MG
Clonidine hydrochloride solid | Mol Wt: 266.55 | 4205-91-8 | MFCD00036705 | 250MG
