Carboximidamides
Apexbio Technology LLC Guanidine HCl 50-01-1 10mM (in 1mL H2O)
Guanidine hydrochloride (Guanidine HCl CAS 50-01-1) is a highly alkaline crystalline compound derived from the oxidative metabolism of guanine Functioning primarily as a strong chaotropic agent it disrupts hydrogen bonding and secondary structure in proteins leading to efficient protein denaturation and solubilization Widely utilized in molecular biology and biochemistry Guanidine HCl facilitates protein unfolding for downstream applications such as protein purification refolding studies and RNA extraction protocols where it also serves to inactivate nucleases and other enzymes
Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 100 G
Guanidine hydrochloride | 50-01-1 | 98.0% | 100 G
AdipoGen Diphenyliodonium PF6
Chemical. CAS 58109-40-3. Formula C12H10F6IP. MW 426.08. Synthetic. Catalyst for the photochemical polymerization of various monomers.
TARGETMOL CHEMICALS INC N-p-Tosyl-GPR-pNA acetate 25MG
Also available in 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.
Medchemexpress LLC Atx inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 g/mol | C21H23Cl2N2O6P | 5 MG
ATX inhibitor 1 is a potent autotaxin (ATX) inhibitor with nanomolar activity (IC50 = 1.23 nM by FS-3 assay; 2.18 nM by bis-pNPP). It is supplied as a solid research compound for in vitro and preclinical research use only.
- Potent autotaxin inhibitor with nanomolar IC50 values (1.23 nM FS-3; 2.18 nM bis-pNPP).
- Molecular formula: C21H23Cl2N2O6P.
- Molecular weight: 501.30 g/mol.
- Purity: 99.3% by HPLC.
- Physical form: solid powder.
- Storage: powder -20°C for 3 years or 4°C for 2 years; in solvent -80°C for 6 months.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, or 10 mM in DMSO solutions.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Nortanshinone | 97399-70-7 | 1 MG
Nortanshinone is a pigment isolated from Dan-Shen, appearing as a brown to reddish-brown solid. It is classified under quinones and naphthalene quinones.
- For laboratory research
- Purity of 98.0%
- Molecular formula: C17H12O4
- Molecular weight: 280.27
- Isolated from plants such as Leguminosae and Labiatae
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | C22H25ClFN3O4S | 10MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of lysyl oxidase-like enzymes LOXL2 and LOXL3, described in the medicinal chemistry literature as a mechanism-based inhibitor with anti-fibrotic activity and high selectivity for LOXL2. It is supplied for research use and has been characterized by CAS, formula, and molecular weight in supplier and public databases.
- Irreversible mechanism-based inhibitor of LOXL2 and LOXL3.
- Greater than 300-fold selectivity for LOXL2 versus LOX.
- Reported Ki ~83 nM for LOXL2 and pIC50 ≈ 8.4.
- Suitable for anti-fibrotic and LOXL biology research.
- Characterized molecular formula and molecular weight for analytical use.
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 10 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. It exhibits good CNS-agent like properties and clinical candidate potential. BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization. In vivo, BNC375 (0.003-10.0 mg/kg, administered orally) exhibits a Minimum Effective Dose (MED) of 0.03 mg/kg, achieving full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model. It has a plasma half-life (t1/2) of 1.2 hours.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent like properties.
- Clinical candidate potential.
- Significantly potentiates acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment in mouse T-maze model.
- Plasma half-life (t1/2) of 1.2 hours.
Medchemexpress LLC Ser-(2,3-Bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe | 322455-70-9 | 99.2% | 1666.16 | 1 MG
FSL-1 is a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to experimental HSV-2 infection. It significantly reduces HSV-2 replication in vitro and in human vaginal epithelial cells, and induces resistance to experimental genital HSV-2 infection via a specific cytokine response. FSL-1 also enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signaling pathway.
- Enhances resistance to experimental HSV-2 infection.
- Reduces HSV-2 replication in vitro and in human vaginal epithelial cells.
- Induces resistance to genital HSV-2 infection through specific cytokine response.
- Enhances phagocytosis of bacteria by macrophages.
- Functions as a TLR2/6 agonist.
AdipoGen 4Me-indotricarbocyanine PF6
Chemical. CAS 134339-08-5. Formula C35H45F6N2P. MW 638.72. Cyanine dye. Spectral Data lambdaex=747nm lambdaem=774nm. Cyanine dyes were first synthesized over a century ago, used to sensitize photographic plates and comprise a diverse family of fluorophores. With their narrow absorption and fluorescence spectral profiles, together with high oscillator strengths for the lowest-energy absorption transition, these dyes are ideal candidates for fluorescence standards for the far-red region.
eMolecules 50-01-1 | Guanidine hydrochloride | Chem-Impex | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 322126117
Guanidine hydrochloride | Chem-Impex | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 250g | 322126117
eMolecules 71556-70-2 | 1-METHYL-3-(3-OXOCYCLOHEX-1-EN-1-YL)AZEPAN-2-ONE | AstaTech | MFCD18432446 | 221.300 | C13H19NO2 | 95.000 | CN1CCCCC(C2=CC(=O)CCC2)C1=O | 0.25g | 384829410
1-METHYL-3-(3-OXOCYCLOHEX-1-EN-1-YL)AZEPAN-2-ONE | AstaTech | 71556-70-2 | MFCD18432446 | 221.300 | C13H19NO2 | 95.000 | CN1CCCCC(C2=CC(=O)CCC2)C1=O | 0.25g | 384829410
![Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243800.png-250.jpg)
Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 25 MG
Theliatinib is a potent, ATP-competitive, orally active, and highly selective epidermal growth factor receptor (EGFR) inhibitor supplied as a research chemical for biochemical and cellular studies. It shows low-nanomolar potency against wild-type EGFR and measurable activity against clinically relevant mutant forms.
- Potent, ATP-competitive EGFR inhibitor with Ki = 0.05 nM and IC50 = 3 nM.
- Active against EGFR T790M/L858R mutant (IC50 ≈ 22 nM).
- High purity (~99.7%) suitable for biochemical and cellular assays.
- Molecular weight 442.51 g/mol; formula C25H26N6O2.
- Soluble in DMSO and supplied for laboratory research use only.