Carboximidamides
Medchemexpress LLC Clonidine (hydrochloride) | 4205-91-8 | 99.9% | 1 G
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It has been studied for its various biological activities.
- Induces CGRP (α and β) mRNA expression in endothelial cells
- Increases NO levels in endothelial cells
- Decreases rat body temperature
- Suppresses dopamine efflux in the prefrontal cortex
- Reduces blood pressure
- Enhances RVLM pERK1/2
Medchemexpress LLC ATX inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 | 10 MM 1 ML
ATX inhibitor 1 is a potent ATX inhibitor, with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP). It is supplied as a white to off-white solid.
- Potent ATX inhibitor
- Molecular weight of 501.30
- Store at -20°C for up to 3 years as powder
- Soluble in DMSO (250 mg/mL)
Medchemexpress LLC Ripk3-in-1 | 2361139-70-8 | 99.3% | 50 MG
RIPK3-IN-1 is a type II DFG-out inhibitor with primary activity against RIPK3. It also demonstrates inhibitory effects on RIPK1, RIPK2, and c-Met kinase. Additionally, it inhibits ABL, BRAF/V599E, MAP4K3, and SRC kinases.
- Inhibits RIPK3 with an IC50 of 9.1 nM
- Inhibits RIPK1 with an IC50 of 5.5 μM
- Inhibits RIPK2 with an IC50 of >10 μM
- Inhibits c-Met kinase with an IC50 of 1.1 μM
- Inhibits ABL with an IC50 of 0.37 μM
- Inhibits BRAF/V599E with an IC50 of 0.15 μM
- Inhibits MAP4K3 with an IC50 of 0.012 μM
- Inhibits SRC with an IC50 of 0.075 μM
Medchemexpress LLC AUDA | 479413-70-2 | 98.0% | 392.58 | 100 MG
AUDA is a potent soluble epoxide hydrolase (sEH) inhibitor that exhibits anti-inflammatory activity. It is effective against both mouse and human sEH, with IC50 values of 18 nM and 69 nM respectively.
- Potent soluble epoxide hydrolase (sEH) inhibitor
- Exhibits anti-inflammatory activity
- Suppresses the proliferation of rat VSMCs
- Upregulates COX-2 expression
- Augments the migratory ability of HCAECs
- Increases the adhesion ability of HCAECs
- Reduces TNF-α, MMP-9, and IL-1β expression levels
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 50 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs, exhibiting an EC50 of 1.9 μM. It possesses good CNS-agent like properties and has clinical candidate potential. It significantly potentiates the acetylcholine signal without altering rapid receptor desensitization.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent-like properties.
- Has clinical candidate potential.
- Significantly potentiates the acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model.
- Minimum effective dose (MED) of 0.03 mg/kg.
- Plasma half-life (t1/2) of 1.2 hours.
Medchemexpress LLC Auda | 479413-70-2 | 98.0% | 392.58 | 1 ML
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor. It exhibits anti-inflammatory activity, making it suitable for various research applications.
- Potent soluble epoxide hydrolase (sEH) inhibitor
- Exhibits anti-inflammatory activity
- Suitable for research applications
Sigma Aldrich Fine Chemicals Biosciences Creatine US Pha200mg
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Selleck Chemical LLC Rhosin hydrochloride 10mM 1mL in DMSOPurity 99.99
Rhosin hydrochloride 10mM 1mL in DMSOPurity 99.99
Medchemexpress LLC Allantoin | 97-59-6 | MFCD00005260 | 98.9% | 158.12 g/mol | C4H6N4O3 | 10 MG
Allantoin analytical standard supplied for research and analytical applications, including method development, calibration, and quality control. It is a crystalline compound with a molecular weight of 158.12 g/mol and reported high purity suitable for laboratory reference use.
- High-purity analytical standard for assay calibration
- Suitable for method development and quality control
- Available in small reference quantities for laboratory use
- Chemical formula C4H6N4O3; molecular weight 158.12 g/mol
- Storage and handling details provided in the certificate of analysis
Medchemexpress LLC Atx inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 g/mol | C21H23Cl2N2O6P | 5 MG
ATX inhibitor 1 is a potent autotaxin (ATX) inhibitor with nanomolar activity (IC50 = 1.23 nM by FS-3 assay; 2.18 nM by bis-pNPP). It is supplied as a solid research compound for in vitro and preclinical research use only.
- Potent autotaxin inhibitor with nanomolar IC50 values (1.23 nM FS-3; 2.18 nM bis-pNPP).
- Molecular formula: C21H23Cl2N2O6P.
- Molecular weight: 501.30 g/mol.
- Purity: 99.3% by HPLC.
- Physical form: solid powder.
- Storage: powder -20°C for 3 years or 4°C for 2 years; in solvent -80°C for 6 months.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, or 10 mM in DMSO solutions.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Smap-2 (DT-1154) | 1809068-70-9 | 99.5% | 5 MG
SMAP-2 (DT-1154) is a small-molecule, orally active activator of protein phosphatase 2A (PP2A) with demonstrated anti-cancer activity in preclinical studies. It is supplied as a white to off-white solid and includes manufacturer-reported solubility and storage guidance.
- Orally bioavailable PP2A activator with anticancer activity.
- High purity: 99.53% (manufacturer reported).
- Molecular weight 532.57; formula C27H27F3N2O4S.
- Soluble in DMSO (300 mg/mL); in vivo formulation guidance provided.
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years).
Medchemexpress LLC PXS-5120A | 2125955-70-4 | MFCD32263436 | 98.1% | 481.97 | C22H25ClFN3O4S | 5 MG
PXS-5120A is a research-grade, irreversible fluoroallylamine inhibitor selective for lysyl oxidase-like 2 and 3 (LOXL2/3) with reported anti-fibrotic activity. It demonstrates high potency for LOXL2 (Ki = 83 nM; pIC50 = 8.4) and >300-fold selectivity over LOXL, and is supplied for laboratory research use.
- Potent irreversible LOXL2/3 inhibitor.
- High selectivity for LOXL2 (Ki = 83 nM).
- Reported anti-fibrotic activity suitable for pathway studies.
- Supplied with reported purity of 98.12%.
- Available in milligram quantities and as a DMSO solution.
Medchemexpress LLC Siguazodan | 115344-47-3 | 99.1% | 10 MG
Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor supplied as a high-purity research reagent. It increases intracellular cAMP, exhibits anti-platelet and vasodilatory activity in preclinical studies, and is provided as a solid suitable for laboratory use.
- Potent and selective PDE3 inhibitor.
- High purity (99.1%).
- Provided as a 10 MG solid for laboratory use.
- Demonstrated anti-platelet and vasodilatory effects in preclinical studies.
- Intended for research and analytical applications only.
![eMolecules AstaTech / [4-(TRIFLUOROMETHYL)PYRIDINE-3-YL]METHYLAMINE / 0.25g / 449739581 / 71541 / 95.000 / 771580-70-2 / MFCD06201889 / 176.142 / C7H7F3N2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502466483.JPG-250.jpg)
eMolecules AstaTech / [4-(TRIFLUOROMETHYL)PYRIDINE-3-YL]METHYLAMINE / 0.25g / 449739581 / 71541 / 95.000 / 771580-70-2 / MFCD06201889 / 176.142 / C7H7F3N2
AstaTech / [4-(TRIFLUOROMETHYL)PYRIDINE-3-YL]METHYLAMINE / 0.25g / 449739581 / 71541 / 95.000 / 771580-70-2 / MFCD06201889 / 176.142 / C7H7F3N2