Guanidines
Medchemexpress LLC Biguanide | 56-03-1 | 98.1% | 25 MG
Biguanide is a small-molecule antihyperglycemic research reagent (CAS 56-03-1) that inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and enhances insulin-receptor signaling. It is intended for research use only.
- Antihyperglycemic activity; modulates mitochondrial metabolism.
- Activates LKB1-AMPK signaling and enhances insulin receptor signaling.
- Molecular formula C2H7N5; molecular weight 101.11 g/mol.
- Supplied as a solid in small pack sizes for research applications.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Zoniporide hydrochloride hydrate | 863406-85-3 | MFCD32004449 | 99.4% | 374.82 g·mol⁻¹ | C17H19ClN6O2 | 10 MG
Zoniporide hydrochloride hydrate is the hydrochloride hydrate salt of zoniporide, a potent and selective inhibitor of the sodium-hydrogen exchanger isoform 1 (NHE-1). It inhibits human NHE-1 with an IC50 of 14 nM and shows strong selectivity over other NHE isoforms, making it suitable for in vitro research on NHE-1-mediated pathways. Supplied as a high-purity solid for laboratory research.
- Potent NHE-1 inhibitor with an IC50 of 14 nM.
- Greater than 150-fold selectivity versus other NHE isoforms.
- High purity suitable for analytical and biological assays (purity reported 99.37%).
- Molecular weight 374.82 g·mol⁻¹.
- Available in small milligram pack sizes for research use.
Medchemexpress LLC Metformin hydrochloride (standard) | 1115-70-4 | 99.97% | 165.62 | 5 MG
Metformin hydrochloride (Standard) is an analytical standard for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful for type 2 diabetes studies. It also inhibits liver oxidative stress and inflammation, and regulates autophagy to inhibit renal cell carcinoma growth.
- Analytical standard for research and analytical applications.
- Inhibits mitochondrial respiratory chain in the liver.
- Activates AMPK and enhances insulin sensitivity.
- Used in type 2 diabetes research.
- Inhibits liver oxidative stress and inflammation.
- Regulates autophagy-related proteins.
- Inhibits mTOR signaling pathway.
- Induces tumor cell autophagy and inhibits renal cell carcinoma growth.
- Suitable for HPLC, GC, and MS research.
Medchemexpress LLC Biguanide | 56-03-1 | 98.1% | 100 MG
Biguanide is an orally active antihyperglycemic research reagent used to investigate mitochondrial metabolism and insulin signaling. It inhibits mitochondrial ATP production and activates the LKB1-AMPK pathway, altering cellular energy homeostasis.
- Used to study mitochondrial metabolism and AMPK signaling.
- Inhibits mitochondrial ATP production.
- Enhances insulin-receptor activation and downstream signaling.
- Typical purity 98.1% for research use.
- Provided as a solid suitable for in vitro and in vivo model studies.
Medchemexpress LLC 4-(2,6-dioxo-1-propyl-1,2,3,6-tetrahydropurin-8-yl)benzene-1-sulfonic acid | 152529-79-8 | >=98.0% | 350.35 g/mol | C14H14N4O5S | 25 MG
PSB-1115 is a research-grade, selective A2B adenosine receptor antagonist used as a tool compound in pharmacology and receptor signaling studies.
- Selective A2B adenosine receptor antagonist.
- Intended for research and analytical applications.
- CAS number 152529-79-8.
- Molecular formula C14H14N4O5S.
- Molecular weight 350.35 g/mol.
- Recommended storage: -20°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Supplied in small quantities suitable for analytical use.
Medchemexpress LLC PSB-1115 | 152529-79-8 | 99.0% | 350.35 g·mol⁻¹ | C14H14N4O5S | 100 MG
PSB-1115 is a selective A2B adenosine receptor antagonist used as a research tool to block A2B-mediated signaling in vitro and in vivo. It is reported to antagonize adenosine-mediated effects in animal models and to inhibit TNBS-induced responses.
- Selective A2B adenosine receptor antagonist for research use.
- High purity (99.0%) solid suitable for biological assays.
- Chemical formula C14H14N4O5S; molecular weight 350.35 g·mol⁻¹.
- Soluble in DMSO (100 mg/mL) and water (10 mg/mL) with sonication or warming.
- Recommended storage at -20°C; in solution, store at -80°C for long-term stability.
- Reported in vivo activity at 0.5 mg/kg (i.p.) in mouse mucociliary clearance studies.
Apexbio Technology LLC PSB 1115 152529-79-8 10mg
PSB 1115 is a selective antagonist targeting the human A2B adenosine receptor It is designed to inhibit receptor-mediated signaling pathways associated with adenosine receptors thereby regulating processes related to inflammation and immune response PSB 1115 exerts its biological activity primarily through antagonism of the A2B adenosine receptor In experimental studies PSB 1115 demonstrates inhibition of acetylcholine-induced contractions triggered by 2 4 6-trinitrobenzene sulfonic acid (TNBS) a commonly used method in gastrointestinal inflammation research Based on these pharmacological properties PSB 1115 holds research potential in investigating inflammatory response immune regulation and mechanisms underlying inflammation-related disorders
Selleck Chemical LLC 1-Phenylbiguanide S2578-25mg
1-Phenylbiguanide (Phenylbiguanide PBG N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3 0 M
Medchemexpress LLC Metformin (hydrochloride) (Standard) | 1115-70-4 | 100.0% | 165.62 | 100 MG
Metformin (hydrochloride) (Standard) | 1115-70-4 | 100.0% | 165.62 | 100 MG