Guanidines
TARGETMOL CHEMICALS INC Metformin 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research. Purity 99.77%
Selleck Chemical LLC Metformin HCl S1950-1g
Metformin HCl (1 1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis) Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
Apexbio Technology LLC Metformin HCl, 50g. Cas: 1115-70-4 MFCD: MFCD00012582. Anti-diabetic drug
Metformin, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug. Metformin inhibits the proliferation of a range of cancer cells including prostate, colon, breast, ovarian, and glioma lines. 1115-70-4. MFCD00012582
Medchemexpress LLC PSB-1115 | 152529-79-8 | 99.0% | 350.35 | C14H14N4O5S | 5 MG
PSB-1115 is a selective A2B adenosine receptor antagonist supplied for research use to investigate A2B-mediated signaling and physiological responses. It has documented activity in TNBS-induced contraction models and is provided in solid and solution formats for experimental applications.
- Selective A2B adenosine receptor antagonist.
- Research-use compound for A2B receptor studies.
- Purity 99.0%.
- Molecular formula C14H14N4O5S; molecular weight 350.35.
- CAS number 152529-79-8.
- Available in solid 5 mg and solution 10 mM 1 mL in DMSO.
- Store at -20°C; protect from light. In solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Phenylbiguanide hydrochloride | 55-57-2 | MFCD00035040 | 98.0% | 213.67 g/mol | C8H12ClN5 | 50 G
Phenylbiguanide hydrochloride is a research-grade small molecule that functions as a selective agonist of the 5-HT3 receptor. Supplied as the hydrochloride salt, it is used in in vitro pharmacology and neuroscience studies to characterize 5-HT3-mediated signaling and downstream GPCR responses.
- Selective 5-HT3 receptor agonist with reported EC50 = 3.0 ± 0.1 μM.
- Suitable for pharmacology and neuroscience research applications.
- Molecular weight 213.67 g/mol; CAS number 55-57-2.
- Available as a bulk reagent; common pack sizes include 50 g.
- Research grade, for in vitro use only; not for human or veterinary use.
Medchemexpress LLC Metformin hydrochloride | 1115-70-4 | 99.9% | 165.62 | 25 MG
Metformin hydrochloride (Standard) is an analytical standard intended for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. It also exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Additionally, it inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. It regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
- Analytical standard
- Used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC PSB-1115 | 152529-79-8 | 99.0% | 350.35 g·mol⁻¹ | C14H14N4O5S | 100 MG
PSB-1115 is a selective A2B adenosine receptor antagonist used as a research tool to block A2B-mediated signaling in vitro and in vivo. It is reported to antagonize adenosine-mediated effects in animal models and to inhibit TNBS-induced responses.
- Selective A2B adenosine receptor antagonist for research use.
- High purity (99.0%) solid suitable for biological assays.
- Chemical formula C14H14N4O5S; molecular weight 350.35 g·mol⁻¹.
- Soluble in DMSO (100 mg/mL) and water (10 mg/mL) with sonication or warming.
- Recommended storage at -20°C; in solution, store at -80°C for long-term stability.
- Reported in vivo activity at 0.5 mg/kg (i.p.) in mouse mucociliary clearance studies.
Selleck Chemical LLC Metformin
Metformin (1 1-Dimethylbiguanide) a widely used drug for treatment of type 2 diabetes activates AMP-activated protein kinase (AMPK) in hepatocytes Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
Sigma Aldrich Fine Chemicals Biosciences Metformin hydrochloride | 1115-70-4 | MFCD00012582 | 200 mg
Metformin hydrochloride | Mol Wt: 165.62 | 1115-70-4 | MFCD00012582 | 200 mg
U.S. Pharmacopeia Metformin hydrochloride, 1115-70-4, MFCD00012582, 200 mg
Linear Formula: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl, Molecular Weight: 165.62, MP: 223-226 °C, Synonym: 1,1-Dimethylbiguanide hydrochloride, Metformin.
Medchemexpress LLC Imidodicarbonimidic diamide, N-phenyl-, hydrochloride | 55-57-2 | 99.8% | 213.67 | C8H12ClN5 | 25 G
Phenylbiguanide hydrochloride is the hydrochloride salt of phenylbiguanide, a selective 5-HT3 receptor agonist commonly used in receptor pharmacology and in vitro pharmacological assays. It is supplied as a research-grade reagent with supporting documentation for characterization and safe handling.
- Selective 5-HT3 receptor agonist (EC50 ≈ 3.0 μM).
- High purity: 99.8% by analytical testing.
- Molecular weight: 213.67 g/mol.
- CAS number: 55-57-2.
- Available in multiple pack sizes, including 25 g.
- Provided with datasheet and safety data sheet for handling and storage.
Apexbio Technology LLC PSB 1115 152529-79-8 10mg
PSB 1115 is a selective antagonist targeting the human A2B adenosine receptor It is designed to inhibit receptor-mediated signaling pathways associated with adenosine receptors thereby regulating processes related to inflammation and immune response PSB 1115 exerts its biological activity primarily through antagonism of the A2B adenosine receptor In experimental studies PSB 1115 demonstrates inhibition of acetylcholine-induced contractions triggered by 2 4 6-trinitrobenzene sulfonic acid (TNBS) a commonly used method in gastrointestinal inflammation research Based on these pharmacological properties PSB 1115 holds research potential in investigating inflammatory response immune regulation and mechanisms underlying inflammation-related disorders