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Isocyanates

Organic compounds that contain a nitrogen atom bonded to a carbon atom that is bonded to an oxygen atom, both bonds are double bonds, in the following structure: R-N=C=O, where R is any carbon chain or group.

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1

Medchemexpress LLC 5-(N,N-hexamethylene)-amiloride | 1428-95-1 | 99.1% | 10 MG
SDP

5-(N,N-Hexamethylene)-amiloride, also known as HMA, is a potent amiloride derivative that functions as an inhibitor of the Na+/H+ exchanger. This action decreases intracellular pH and induces apoptosis in leukemic cells. It also acts as an inhibitor of the HIV-1 Vpu virus ion channel, demonstrating efficacy against the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells. This product is intended for research use only.

  • Potent Na+/H+ exchanger inhibitor
  • Induces apoptosis in leukemic cells
  • Inhibits HIV-1 Vpu virus ion channel
  • Inhibits replication of mouse hepatitis virus (MHV)
  • Inhibits replication of human coronavirus 229E (HCoV229E)
  • High purity (99.1%)

ENCOMPASS_PREFERRED
2

Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 99.1% | 1 ML
SDP

5-(N,N-Hexamethylene)-amiloride, also known as Hexamethylene amiloride (HMA), is a potent Na+/H+ exchanger inhibitor derived from amiloride. It effectively decreases intracellular pH (pHi) and has been shown to induce apoptosis in leukemic cells. This compound also acts as an inhibitor of the HIV-1 Vpu virus ion channel and inhibits the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells.

  • Potent Na+/H+ exchanger inhibitor
  • Decreases intracellular pH (pHi)
  • Induces apoptosis in leukemic cells
  • Inhibits HIV-1 Vpu virus ion channel
  • Inhibits replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E)
  • Inhibits human cardiac ion channels hERG, Nav1.5, and Cav1.2
  • Exhibits microsomal and mouse plasma stability
  • Displays Caco-2 cell permeability

ENCOMPASS_PREFERRED
3

Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 99.1% | 50 MG
SDP

5-(N,N-Hexamethylene)-amiloride is a derivative of amiloride and acts as a potent inhibitor of the Na+/H+ exchanger. This inhibition leads to a decrease in intracellular pH (pHi) and triggers apoptosis in leukemic cells. Additionally, it functions as an inhibitor of the HIV-1 Vpu virus ion channel. It has been shown to inhibit the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells, with EC50 values of 3.91 μM and 1.34 μM, respectively.

  • Potent Na+/H+ exchanger inhibitor.
  • Decreases intracellular pH (pHi).
  • Induces apoptosis in leukemic cells.
  • Inhibits HIV-1 Vpu virus ion channel.
  • Inhibits mouse hepatitis virus (MHV) replication.
  • Inhibits human coronavirus 229E (HCoV229E) replication.
  • Available in solid form, light yellow to yellow in color.
  • Purity of 99.1%.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 99.14% | 311.77 | 5 MG
SDP

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is a derivative of amiloride, functioning as a potent Na+/H+ exchanger inhibitor. It effectively decreases intracellular pH and induces apoptosis in leukemic cells. Furthermore, it inhibits the HIV-1 Vpu virus ion channel and has been shown to suppress the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells.

  • Potent Na+/H+ exchanger inhibitor
  • Decreases intracellular pH
  • Induces apoptosis in leukemic cells
  • Inhibits HIV-1 Vpu virus ion channel
  • Suppresses mouse hepatitis virus (MHV) replication
  • Suppresses human coronavirus 229E (HCoV229E) replication
  • Inhibits human cardiac ion channels hERG, Nav1.5, and Cav1.2
  • Exhibits microsomal stability
  • Shows mouse plasma stability and plasma protein binding
  • Displays Caco-2 cell permeability

ENCOMPASS_PREFERRED
5

Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | >99.1% | 100 MG
SDP

5-(N,N-Hexamethylene)-amiloride (HMA) is a potent Na+/H+ exchanger inhibitor derived from amiloride. It effectively decreases intracellular pH and induces apoptosis in leukemic cells. Additionally, it functions as an inhibitor of the HIV-1 Vpu virus ion channel and demonstrates inhibitory effects on the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells.

  • Potent Na+/H+ exchanger inhibitor
  • Decreases intracellular pH
  • Induces apoptosis in leukemic cells
  • Inhibits HIV-1 Vpu virus ion channel
  • Inhibits mouse hepatitis virus (MHV) replication
  • Inhibits human coronavirus 229E (HCoV229E) replication
  • Purity of >99.1%
  • Store powder at -20°C for 3 years or 4°C for 2 years
  • Store in solvent at -80°C for 2 years or -20°C for 1 year

ENCOMPASS_PREFERRED