Oximes
Apexbio Technology LLC Indirubin-3'-oxime 160807-49-8 50mg
Indirubin-3 -oxime (CAS 160807-49-8) is a derivative of indirubin investigated primarily as an inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 22 nM This compound also inhibits CDK5/p25 and CDK1/cyclin B with IC50 values of around 100 nM and 180 nM respectively while demonstrating weaker inhibitory activity against 5-lipoxygenase (IC50 7 8 10 M) Due to its modulation of multiple kinases involved in cell signaling Indirubin-3 -oxime is widely utilized in research on cellular signaling pathways and the molecular mechanisms underlying disease
![eMolecules 177610-87-6 | (E)-7-(HYDROXYIMINO)-N-PHENYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE-1A-CARBOXAMIDE | AstaTech | MFCD00947860 | 294.310 | C17H14N2O3 | 98.000 | O\N=C1/C2CC2(Oc2ccccc12)C(=O)Nc1ccccc1 | 0.25g | 338842108](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502481449.JPG-250.jpg)
eMolecules 177610-87-6 | (E)-7-(HYDROXYIMINO)-N-PHENYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE-1A-CARBOXAMIDE | AstaTech | MFCD00947860 | 294.310 | C17H14N2O3 | 98.000 | O\N=C1/C2CC2(Oc2ccccc12)C(=O)Nc1ccccc1 | 0.25g | 338842108
(E)-7-(HYDROXYIMINO)-N-PHENYL-1,1A,7,7A-TETRAHYDROCYCLOPROPA[B]CHROMENE-1A-CARBOXAMIDE | AstaTech | 177610-87-6 | MFCD00947860 | 294.310 | C17H14N2O3 | 98.000 | O\N=C1/C2CC2(Oc2ccccc12)C(=O)Nc1ccccc1 | 0.25g | 338842108
Sigma Aldrich Fine Chemicals Biosciences 2,3-Butanedione monoxime >=98% | 57-71-6 | MFCD00002116 | 500G
2,3-Butanedione monoxime >=98% | Purity: >=98% | Mol Wt: 101.1 | 57-71-6 | MFCD00002116 | 500G
Selleck Chemical LLC 2.3-Butanedione-2-monoxime S3699-1g
2 3-Butanedione monoxime (BDM Diacetyl monoxime Diacetylmonoxime) is the well-characterized low-affinity non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction
TARGETMOL CHEMICALS INC Indirubin-3-monoxime 25MG
Also available in 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3beta (IC50 22 nM) and also inhibits CDKs ( (IC50s 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). Purity 99.65%
![eMolecules 667463-82-3 | Ambeed | (2Z3E)-3-(Hydroxyimino)-[23-biindolinylidene]-2-one | 25mg | 632809158 | A164297 | MFCD02683594 | 277.283 | C16H11N3O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502483433.JPG-250.jpg)
eMolecules 667463-82-3 | Ambeed | (2Z3E)-3-(Hydroxyimino)-[23-biindolinylidene]-2-one | 25mg | 632809158 | A164297 | MFCD02683594 | 277.283 | C16H11N3O2
Ambeed | (2Z3E)-3-(Hydroxyimino)-[23-biindolinylidene]-2-one | 25mg | 632809158 | A164297 | 667463-82-3 | MFCD02683594 | 277.283 | C16H11N3O2
eMolecules 74213-24-4 | dibromomethanone oxime | Pharmablock | MFCD06796211 | 202.833 | CHBr2NO | 97.000 | ON=C(Br)Br | 1g | 783662167
dibromomethanone oxime | Pharmablock | 74213-24-4 | MFCD06796211 | 202.833 | CHBr2NO | 97.000 | ON=C(Br)Br | 1g | 783662167
eMolecules 459-23-4 | Ambeed | 4-Fluorobenzaldehyde oxime | 5g | 491646374 | A234346 | MFCD00133101 | 139.129 | C7H6FNO
Ambeed | (2-Bromo-4-(trifluoromethoxy)phenyl)boronic acid | 100mg | 717401737 | A784081 | 959997-86-5 | MFCD19237163 | 284.820 | C7H5BBrF3O3
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eMolecules Building Block Tool
AdipoGen Propionaldehyde oxime
Chemical. CAS 627-39-4. Formula C3H7NO. MW 73.09. Synthetic Building block for synthesis.
Cayman Chemical 3-Pyridylamide oxime, Purity: ≥98%, CAS: 1594-58-7, 500 mg
A synthetic intermediate useful for pharmaceutical synthesis
Medchemexpress LLC Glucosylceramide synthase-IN-2 | 2597958-02-4 | 98.62% | C22H20F3N3O4 | 1 ML
Glucosylceramide synthase-IN-2 is a potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS). It demonstrates IC50 values of 15 nM for human GCS and 190 nM for mouse GCS, exhibiting noncompetitive inhibition with C8-ceramide and UDP-glucose. This compound is applicable for research related to Gaucher's disease, showing no significant inhibitory activity against SERT or GCase in vitro. In vivo studies confirm good oral and brain exposure in mice, reducing GlcCer concentrations in plasma and cerebral cortex.
- Potent GCS inhibitor
- Brain-penetrant
- Orally active
- Noncompetitive inhibition type with C8-ceramide and UDP-glucose
- Useful for Gaucher's disease research
- Does not significantly inhibit SERT or GCase activity in vitro
- Shows good oral and brain exposure in vivo
Medchemexpress LLC S.pombe lumazine synthase-IN-1 | 331726-35-3 | 98.0% | 319.27 | 10 MM * 1 ML
S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases, demonstrating Ki values of 243 μM for *Schizosaccharomyces pombe* and 9.6 μM for *Mycobacterium tuberculosis* lumazine synthases. It is intended for research use only.
- Inhibitor of lumazine synthases.
- Specific Ki values for *Schizosaccharomyces pombe* (243 μM) and *Mycobacterium tuberculosis* (9.6 μM).
- Class II compound with OCH3 groups showing slightly better potencies compared to counterparts with OH groups.
- Provided with Data Sheet, COA, SDS, and Handling Instructions.
- Available in various forms including solid and solution in DMSO.
- Can be stored as powder at -20°C for 3 years or 4°C for 2 years, and in solvent at -80°C for 6 months or -20°C for 1 month.
- Related to anti-infection, bacterial infection, fungal infection, and *Mycobacterium tuberculosis* infection research.
BIOHIPPO Syn-JGCamP7b-Puro LV
Syn-JGCamP7b-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
Aobchem (E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 25g
(E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 25g
Aobchem (E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 500mg
(E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 500mg